Assessing Environmental Exposures to Persistent Organic Pollutants in Assisted Living Facilities

评估辅助生活设施中持久性有机污染物的环境暴露

• 批准号: 10022518
• 负责人: Joseph R. Shaw
• 金额: $ 23.78万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-23 至 2023-10-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022518
• 关键词: Address; Affect; Aging; Air; Aromatic Polycyclic Hydrocarbons; Assisted Living Facilities; Biological Markers; Biological Monitoring; Cardiovascular Diseases; Censuses; Central obesity; Chemical Exposure; Chemicals; Construction Materials; Country; Data; Data Collection; Deterioration; Development; Dust; Elderly; Electronics; Environment; Environmental Exposure; Environmental Health; Environmental Pollution; Esters; Europe; European; Exposure to; Fire - disasters; Flame Retardants; Foundations; Furniture; Future; Goals; Hazardous Chemicals; Health; Health care facility; Household; Hypertension; Indiana; Individual; Indoor environment; Intervention; Knowledge; Long-Term Care; Measurement; Measures; Metabolic Diseases; Mission; Nail plate; Nitrogen Dioxide; Non-Insulin-Dependent Diabetes Mellitus; Organic Chemicals; Organophosphates; Ozone; Participant; Particulate Matter; Pest Control; Pesticides; Physiological; Policies; Polychlorinated Biphenyls; Population; Population Group; Prevalence; Production; Public Health; Quality of life; Regulation; Research; Risk; Safety; Sampling; Silicones; Source; System; Techniques; Time; Translations; United States; United States National Institutes of Health; Vulnerable Populations; Work; base; cohort; epidemiology study; exposed human population; human old age (65+); improved; indoor exposure; innovation; novel; organochlorine pesticide; persistent organic pollutants; pressure; prevent; programs; recruit; respiratory; therapy development

Project Summary Abstract There is a fundamental gap in understanding how indoor exposures to environmental contaminants affect the health of older adults living or spending time in senior care facilities. Continued existence of this gap represents an important problem, because until it is filled, development of interventions and regulations to reduce health risks associated with indoor exposures in senior care facilities will remain unattainable. The long-term goal of our research program is to examine risks associated with exposure to persistent organic pollutants (POPs) in senior care facilities for future development and implementation of interventions to prevent or reduce these risks. Our objective in this application is to determine the connection between ambient conditions, personal exposures, and biomarkers of exposure to POPs among the residents of senior care facilities located in Indiana. We hypoth- esize that there is a significant association between ambient conditions, personal exposures, and biomarkers of exposure in senior care facilities. Our rationale for the proposed study is that the knowledge obtained through this research will advance our understanding of the impacts of indoor exposure to POPs on health of the resi- dents of senior care facilities. We will use innovative non-invasive data collection techniques to pursue the fol- lowing specific aims: 1) Determine ambient levels of five POP groups (polychlorinated biphenyls, organochlorine pesticides, polycyclic aromatic hydrocarbons, brominated flame retardants, and organophosphate esters) in sen- ior care facilities in Indiana via air and dust sampling; 2) Estimate personal exposures to target chemicals among residents of the facilities using silicone wristbands as personal passive samplers; 3) Determine biomarkers of exposure to POPs through analysis of nails, a non-invasive biomonitoring technique. The study will recruit 100 residents of senior care facilities located in Indiana (10 facilities with 10 participants per facility) for the exposure assessments. We will examine indoor exposures through air and dust sampling in participants' rooms. We will use silicone wristbands as innovative passive samplers of personal exposures and we will measure biomarkers of POPs in nail clippings collected from participants. This approach is innovative because it examines a previ- ously unrecognized exposure to POPs in an understudied settings with particularly vulnerable population, and because it employs silicone wristbands and nails as novel, simple, and non-invasive ways to measure personal exposures and biomarkers of exposure. The proposed research is significant because accomplishing these spe- cific aims will advance our understanding of how exposure to POPs may impact health of a vulnerable population of older adults. This information will provide an essential foundation for subsequent applications to investigate and reduce risks associated with this exposure through epidemiological studies and targeted interventions.

项目概要 摘要 在理解室内暴露于环境污染物如何影响人体健康方面存在着根本性的差距。 生活在高级护理机构或在高级护理机构中度过时间的老年人的健康状况。这一差距的持续存在表明 这是一个重要的问题，因为在这个问题得到解决之前，制定干预措施和法规来减少健康 与高级护理机构室内暴露相关的风险仍将难以实现。长期目标是 我们的研究计划是检查与接触持久性有机污染物 (POP) 相关的风险 高级护理机构未来制定和实施干预措施以预防或减少这些风险。 我们在此应用中的目标是确定环境条件、个人暴露、 以及印第安纳州高级护理机构居民接触持久性有机污染物的生物标志物。我们假设—— 认为环境条件、个人暴露和生物标志物之间存在显着关联 暴露在高级护理机构中。我们提出的研究的理由是通过获得的知识 这项研究将加深我们对室内接触持久性有机污染物对抵抗力健康影响的了解。 高级护理设施的凹痕。我们将使用创新的非侵入性数据收集技术来追求以下目标： 降低具体目标： 1) 确定五种持久性有机污染物（多氯联苯、有机氯）的环境水平 农药、多环芳烃、溴化阻燃剂和有机磷酸酯） 印第安纳州的医疗机构通过空气和灰尘采样； 2) 估计个人对目标化学品的暴露量 使用硅胶腕带作为个人被动采样器的设施居民； 3) 确定生物标志物 通过分析指甲（一种非侵入性生物监测技术）来了解持久性有机污染物的暴露情况。该研究将招募100名 印第安纳州高级护理机构的居民（10 个机构，每个机构 10 名参与者）进行暴露 评估。我们将通过参与者房间的空气和灰尘采样来检查室内暴露情况。我们将 使用硅胶腕带作为个人暴露的创新被动采样器，我们将测量生物标志物 从参与者收集的指甲剪中持久性有机污染物的含量。这种方法是创新的，因为它检查了先前的 在未充分研究的环境中，尤其是弱势群体中，持久性有机污染物的暴露未被充分认识到，以及 因为它采用硅胶腕带和指甲作为新颖、简单且非侵入性的个人测量方式 暴露和暴露的生物标志物。拟议的研究意义重大，因为完成这些特定 具体目标将加深我们对持久性有机污染物接触如何影响弱势群体健康的理解 的老年人。这些信息将为后续应用调查提供重要基础 通过流行病学研究和有针对性的干预措施降低与这种暴露相关的风险。