2013 Cartilage Biology and Pathology: Formation, Structure, Function, and Regener

2013 软骨生物学和病理学：形成、结构、功能和再生

• 批准号: 8521693
• 负责人: ROCKY S TUAN
• 金额: $ 2.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8521693
• 关键词: Academia; Address; Adult; Biochemistry; Biology; Biomechanics; Birth; Bone Marrow; Bone Tissue; Cartilage; Cartilage Diseases; Cellular biology; Cessation of life; Chemicals; Childhood; Clinical; Collaborations; Complex; Data; Degenerative Disorder; Degenerative polyarthritis; Development; Diagnosis; Discipline; Disease; Engineering; Environmental Risk Factor; Europe; Event; Fostering; Friction; Future; Genes; Genetic; Goals; Government; Growth; In Vitro; Industry; Interdisciplinary Study; Investigation; Joints; Knowledge; Life; Maintenance; Mediating; Mentors; Modeling; Molecular Biology; Natural regeneration; Occupational; Orthopedics; Pain; Participant; Pathology; Postdoctoral Fellow; Prevalence; Prevention; Research; Research Personnel; Rheumatoid Arthritis; Rheumatology; Risk; Scientist; Senior Scientist; Series; Shock; Signal Pathway; Site; Skeleton; Source; Stem cells; Structure; Surface; Switzerland; Technology; Therapeutic; Time; Tissue Engineering; Tissues; Vertebral column; aging population; bone; cellular engineering; congenital skeletal disorder; disability; effective therapy; graduate student; improved; in vivo; insight; interdisciplinary collaboration; interest; intervertebral disk degeneration; meetings; novel; planetary Atmosphere; posters; programs; public health relevance; repaired; stem; success; symposium; synthetic biology; translational medicine; treatment strategy; vertebra body

DESCRIPTION (provided by applicant): This is a request for support for the sixth meeting in a highly successful series of Gordon Research Conferences on Cartilage Biology and Pathology, to be held at the Gordon Conference site at 'Les Diablerets, Switzerland', April 7-12, 2013. Building on the success of the previous conferences, the meeting brings together outstanding senior and junior scientists, with a special emphasis on advanced graduate students and postdoctoral fellows, for a 4.5-day program of formal presentations, poster sessions, and intensive informal discussions. The participants share an interest in cartilage biology and pathology, but represent a broad range of disciplines, including genetics, development and differentiation, biochemistry, cell and molecular biology, tissue engineering, degeneration and regeneration, synthetic biology, rheumatology, and orthopaedics. When cartilage fails, the consequences can be severe, ranging from death near the time of birth to reduced growth of the skeleton during childhood, and degenerative joint diseases and physical disability in adults. The prevalence of adult diseases of cartilage is increasing in the aging population of the world. During recent years, great strides have been made in the identification of genes, which control cartilage formation, and the mechanisms by which they act. Similarly, comprehensive investigations have accelerated the identification of loci that predispose to degenerative diseases. At the same time, the rapid development of stem cell and tissue engineering technologies are increasing the options for repair and regeneration of damaged cartilage. However, the transfer of basic knowledge into translational medicine has still to be improved and requires the intensive interaction of scientist with different fields of expertise. This meetin will bring together experts from a wide spectrum of established and emerging scientific disciplines, to address where we stand today with respect to understanding the basic mechanisms and therapeutic potentials of cartilage diseases, and what developments are in the pipeline. This is the ONLY meeting that brings together such a broad spectrum of researchers in an informal setting, where it is possible to interact and discuss extensively. The conference is held every other year, alternating between a site in Europe and a site in the US, maximizing opportunities for interactions with colleagues around the world. The meeting is distinctive in its ability to provide junior scientists, postdoctoral fellows, and advanced graduate students extensive access to senior scientists, enabling mentoring, networking, and establishment of collaborations. The conference has consistently been rated as "outstanding" by the participants. The basic format, providing ample time for informal discussions, remains thus unchanged from our previous highly successful conferences.

描述（由申请人提供）：这是一份关于软骨生物学和病理学的戈登研究会议系列的第六次会议的支持请求，该会议将于2013年4月7日至12日在瑞士Les diableets的戈登会议现场举行。在前几届会议成功的基础上，这次会议汇集了优秀的高级和初级科学家，特别强调高级研究生和博士后研究员，为期4.5天的正式演讲，海报会议和密集的非正式讨论。参与者对软骨生物学和病理学有共同的兴趣，但代表了广泛的学科，包括遗传学，发育和分化，生物化学，细胞和分子生物学，组织工程，变性和再生，合成生物学，风湿病学和骨科。当软骨衰竭时，后果可能很严重，从出生时死亡到儿童时期骨骼生长减缓，以及退行性关节疾病和成人身体残疾。成人软骨疾病的患病率在世界人口老龄化中呈上升趋势。近年来，在识别控制软骨形成的基因及其作用机制方面取得了巨大进展。同样，全面的研究加速了对易患退行性疾病的基因座的识别。与此同时，干细胞和组织工程技术的快速发展增加了修复和再生受损软骨的选择。然而，将基础知识转化为转化医学仍有待改进，需要不同专业领域的科学家密切互动。本次会议将汇集来自广泛的已建立和新兴科学学科的专家，讨论我们今天在理解软骨疾病的基本机制和治疗潜力方面所处的位置，以及正在进行的发展。这是唯一一次将如此广泛的研究人员聚集在非正式环境中的会议，在这里可以进行广泛的互动和讨论。会议每两年举行一次，在欧洲和美国轮流举行，最大限度地增加了与世界各地同事互动的机会。该会议的独特之处在于它能够为初级科学家、博士后研究员和高级研究生提供与高级科学家广泛接触的机会，从而实现指导、网络和建立合作。会议一直被与会者评为“优秀”。因此，为非正式讨论提供充足时间的基本形式同我们以前非常成功的会议一样没有变化。