2013 Cartilage Biology and Pathology: Formation, Structure, Function, and Regener

2013 软骨生物学和病理学：形成、结构、功能和再生

• 批准号: 8521693
• 负责人: ROCKY S TUAN
• 金额: $ 2.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8521693
• 关键词: Academia; Address; Adult; Biochemistry; Biology; Biomechanics; Birth; Bone Marrow; Bone Tissue; Cartilage; Cartilage Diseases; Cellular biology; Cessation of life; Chemicals; Childhood; Clinical; Collaborations; Complex; Data; Degenerative Disorder; Degenerative polyarthritis; Development; Diagnosis; Discipline; Disease; Engineering; Environmental Risk Factor; Europe; Event; Fostering; Friction; Future; Genes; Genetic; Goals; Government; Growth; In Vitro; Industry; Interdisciplinary Study; Investigation; Joints; Knowledge; Life; Maintenance; Mediating; Mentors; Modeling; Molecular Biology; Natural regeneration; Occupational; Orthopedics; Pain; Participant; Pathology; Postdoctoral Fellow; Prevalence; Prevention; Research; Research Personnel; Rheumatoid Arthritis; Rheumatology; Risk; Scientist; Senior Scientist; Series; Shock; Signal Pathway; Site; Skeleton; Source; Stem cells; Structure; Surface; Switzerland; Technology; Therapeutic; Time; Tissue Engineering; Tissues; Vertebral column; aging population; bone; cellular engineering; congenital skeletal disorder; disability; effective therapy; graduate student; improved; in vivo; insight; interdisciplinary collaboration; interest; intervertebral disk degeneration; meetings; novel; planetary Atmosphere; posters; programs; public health relevance; repaired; stem; success; symposium; synthetic biology; translational medicine; treatment strategy; vertebra body

DESCRIPTION (provided by applicant): This is a request for support for the sixth meeting in a highly successful series of Gordon Research Conferences on Cartilage Biology and Pathology, to be held at the Gordon Conference site at 'Les Diablerets, Switzerland', April 7-12, 2013. Building on the success of the previous conferences, the meeting brings together outstanding senior and junior scientists, with a special emphasis on advanced graduate students and postdoctoral fellows, for a 4.5-day program of formal presentations, poster sessions, and intensive informal discussions. The participants share an interest in cartilage biology and pathology, but represent a broad range of disciplines, including genetics, development and differentiation, biochemistry, cell and molecular biology, tissue engineering, degeneration and regeneration, synthetic biology, rheumatology, and orthopaedics. When cartilage fails, the consequences can be severe, ranging from death near the time of birth to reduced growth of the skeleton during childhood, and degenerative joint diseases and physical disability in adults. The prevalence of adult diseases of cartilage is increasing in the aging population of the world. During recent years, great strides have been made in the identification of genes, which control cartilage formation, and the mechanisms by which they act. Similarly, comprehensive investigations have accelerated the identification of loci that predispose to degenerative diseases. At the same time, the rapid development of stem cell and tissue engineering technologies are increasing the options for repair and regeneration of damaged cartilage. However, the transfer of basic knowledge into translational medicine has still to be improved and requires the intensive interaction of scientist with different fields of expertise. This meetin will bring together experts from a wide spectrum of established and emerging scientific disciplines, to address where we stand today with respect to understanding the basic mechanisms and therapeutic potentials of cartilage diseases, and what developments are in the pipeline. This is the ONLY meeting that brings together such a broad spectrum of researchers in an informal setting, where it is possible to interact and discuss extensively. The conference is held every other year, alternating between a site in Europe and a site in the US, maximizing opportunities for interactions with colleagues around the world. The meeting is distinctive in its ability to provide junior scientists, postdoctoral fellows, and advanced graduate students extensive access to senior scientists, enabling mentoring, networking, and establishment of collaborations. The conference has consistently been rated as "outstanding" by the participants. The basic format, providing ample time for informal discussions, remains thus unchanged from our previous highly successful conferences.

描述(由申请人提供)：这是关于软骨生物学和病理学的戈登研究系列会议中非常成功的第六次会议的支持请求，该会议将于2013年4月7日至12日在瑞士Les Diablerets的戈登会议现场举行。在前几届会议成功的基础上，这次会议汇集了杰出的资深和初级科学家，特别强调高级研究生和博士后研究员，为期4.5天的正式报告、海报会议和密集的非正式讨论。与会者对软骨生物学和病理学有共同的兴趣，但代表了广泛的学科，包括遗传学、发育和分化、生物化学、细胞和分子生物学、组织工程、退化和再生、合成生物学、风湿病和骨科。当软骨衰竭时，后果可能很严重，从出生时附近死亡，到童年时期骨骼生长减慢，以及成年人的退行性关节疾病和身体残疾。在世界老龄化人口中，成人软骨疾病的患病率正在增加。近年来，在识别控制软骨形成的基因及其作用机制方面取得了长足的进步。同样，全面的调查加快了对易患退行性疾病的基因座的识别。与此同时，干细胞和组织工程技术的快速发展增加了修复和再生受损软骨的选择。然而，基础知识向转化医学的转化仍有待改进，需要不同专业领域的科学家密集互动。这次会议将汇集来自现有和新兴科学学科的广泛领域的专家，讨论我们今天在理解软骨疾病的基本机制和治疗潜力方面所处的地位，以及正在进行的发展。这是唯一一次将如此广泛的研究人员在非正式环境中聚集在一起的会议，有可能进行广泛的互动和讨论。会议每隔一年举行一次，轮流在欧洲和美国举行，最大限度地增加与世界各地同事互动的机会。会议的独特之处在于，它能够为初级科学家、博士后研究员和高级研究生提供广泛的接触高级科学家的机会，使指导、网络和建立合作成为可能。大会历来被与会嘉宾评为“杰出”。因此，为非正式讨论提供了充足时间的基本形式与我们以往极为成功的会议保持不变。