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Neuronanomedicine

神经纳米医学

基本信息

批准号：
8529879
负责人：
Howard E Gendelman
金额：
$ 2.5万
依托单位：
AMERICAN SOCIETY FOR NANOMEDICINE I
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-15 至 2014-03-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8529879
关键词：
Affect American Animal Testing Applied Research Area Basic Science Behavior Disorders Bioethics Biology Blood - brain barrier anatomy Brain Brain region Cells Clinical Clinical Trials Communicable Diseases Community Healthcare Data Development Diagnosis Diagnostic Discipline Disease District of Columbia Drug Industry Drug Targeting Educational process of instructing Engineering Environment Equilibrium Ethics Evolution Fostering Future Gender Glean Goals Health Personnel Human Industry Inflammatory Institutes Intellectual Property Journals Laboratories Laboratory Animals Lead Leadership Learning Location Malignant Neoplasms Measures Medicine Mentorship Metabolic Diseases Minority Monitor Nanotechnology Nerve Degeneration Nervous system structure Neurologist Neurosciences Neurosurgeon Oral Outcome Outcomes Research Patients Pharmaceutical Preparations Pharmacologic Substance Pharmacology Pharmacy (field)Physicians Positioning Attribute Principles of law and justice Psychiatrist Publications Publishing Quality Control Regenerative Medicine Request for Proposals Research Research Personnel Rest Role Safety Science Scientist Seasons Societies Solutions Students Technology Testing Therapeutic Toxic effect Training Translations Vascular Diseases Work addiction base bioimaging career clinical toxicology commercialization disorder prevention experience implantation improved infancy innovation insight interest meetings multidisciplinary nanobiology nanofabrication nanoimaging nanomaterials nanomedicine nanosurgery nanotoxicology nervous system disorder new technology next generation novel outreach posters product development programs protein misfolding public health relevance relating to nervous system repaired social success symposium web page web site

项目摘要

DESCRIPTION (provided by applicant): Neuronanomedicine is a new research field defined as the development and translation of nanotechnology for diagnosis and treatment of degenerative, inflammatory, infectious, vascular, addictive, behavioral and metabolic disorders of the nervous system. The research discipline is interdisciplinary and in its infancy. Hurdles need be overcome for success to be realized that improve known blood brain barrier restrictions, nanotoxicologies, inefficient drug targeting to diseased brain regions and in reaching specific neural subcellular compartments. These all pose significant challenges to the field. To facilitate successful research outcomes we plan to bring together scientists from divergent backgrounds engaged in neuronanomedicine to present research findings that will help define the field while also facilitating opportunities for trainees to directly engage in currnt and future discussions. The American Society for Nanomedicine (ASNM) has taken a leadership role by focusing its 2013 meeting to the multifaceted discipline of neuronanomedicine. The ASNM is well positioned to assume this role as the society's goals since its 2008 inception has rested in clinical translation of nanotechnologies. Such goals will be fostered in an open forum discussion that will include, but is not limited to, bioethics, safety an toxicity, intellectual property, and product commercialization. A major focus for the conference is in bringing early career investigators into the field of translational neuronanomedicine. ASNM's emphasis on innovation and practicality of approaches for speedy translation parallels the conference goals on merging divergent disciplines and approaches to facilitate collaborative research from product development to laboratory and animal testing and ultimately to human clinical trials. The proposal while led by an experienced physician-scientist, Dr. Howard Gendelman, takes advantage of a highly seasoned broad-disciplined board. Overall, the focus on the nervous system represents an evolution of ASNM leadership and a further change in direction for the meeting. It will enable new directives in the field to keep abreast with needs an research scope in nanotechnology.

描述（由申请人提供）：神经医学是一个新兴的研究领域，被定义为发展和转化纳米技术来诊断和治疗神经系统的退行性、炎症、感染性、血管性、成瘾性、行为和代谢紊乱。该研究学科是跨学科的，处于起步阶段。要想取得成功，还需要克服一些障碍，如改善已知的血脑屏障限制、纳米毒理学、药物靶向病变脑区效率低下以及到达特定的神经亚细胞区室。这些都给该领域带来了重大挑战。为了促进成功的研究成果，我们计划将来自不同背景的从事神经医学的科学家聚集在一起，展示有助于定义该领域的研究成果，同时也为学员直接参与当前和未来的讨论提供机会。美国纳米医学学会（ASNM）在2013年的会议上发挥了领导作用，重点讨论了神经医学的多学科。自2008年成立以来，ASNM一直致力于纳米技术的临床转化，因此ASNM很好地定位于承担这一角色。这些目标将是