Neuroimmunology of Disease Training Program

疾病神经免疫学培训计划

• 批准号: 10200159
• 负责人: Howard E Gendelman
• 金额: $ 18.99万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200159
• 关键词: Disease; Training Programs; neuroimmunology

ABSTRACT Despite advances in basic and translational neuroscience research, the development of new therapeutics remains in want. The National Institutes of Health has recognized the need to translate bench research to therapies that improve human disease outcomes and initiated programs that train researchers who can effectively conceptualize neurological disease processes. One critical “in need” area is in the discipline of neuroimmunity. This research area remains understudied despite its close linkage to the pathobiology of degenerative, infectious, developmental, and psychiatric disorders. To these ends, our training goal is to provide talented students with a fundamental understanding of peripheral and central immunology as it affects neuronal injury, differentiation, regeneration, and protection. The program is designed to provide the student with broad exposure to research methods that facilitate technical proficiency. The program ensures that the student will acquire broad knowledge in neuroimmunity. This would allow critical thinking for how inflammation affects the pathogenesis and treatment of neurological disorders. Several approaches are proposed to achieve this goal. First, is the use of our newly published textbook Neuroimmune Pharmacology (2nd Ed.) designed specifically as a coursework guide in neuroscience, immunology, and pharmacology. Second, is in developing a cross discipline mentorship training to provide the student with opportunities to intersect studies of immunity and neural function. Third, are “unique” research experiences in systems biology, cell signaling, glial and neuronal biology, human disease models and synaptic physiology. These opportunities serve to complement research in neural genetics, development, repair, and pharmacology. Fourth, are formal student presentations to interdisciplinary basic neuroscientists and supervisory committees to acquire research feedback in design, interpretation and conceptualization of ongoing research activities. This serves to challenge existing paradigms and existing student perceptions. Fifth, are uniquely offered cross-discipline team mentoring, teaching, and clinical neurological experiences. Sixth, are cross-disciplinary internships where students will complete thesis component(s) in another laboratory using a different research approach and mentor. Seventh, are sustained community, university and logistical support. By coordinating the training efforts of divergent research groups linked by common interests in neuroimmunity trainees will develop deeper understandings of innate and adaptive immunity in relationship to neurologic disease. Such trainees will be better prepared to develop successful careers in studies of disease pathobiology and therapeutic interventions for human nervous system disorders.

摘要 尽管基础和转化神经科学研究取得了进展，但新疗法的发展 仍然处于匮乏之中。美国国立卫生研究院已经认识到有必要将实验室研究转化为 改善人类疾病结果的疗法，并启动了培训研究人员的计划， 有效地概念化神经疾病过程。一个关键的“需要”领域是 神经免疫这一研究领域仍然研究不足，尽管其密切联系的病理生物学， 退行性、传染性、发育和精神障碍。为此，我们的培训目标是 为有才华的学生提供外周和中枢免疫学的基本理解，因为它影响 神经元损伤、分化、再生和保护。该计划旨在为学生提供 广泛接触促进技术熟练的研究方法。该计划确保， 学生将获得广泛神经免疫学知识。这将允许批判性思考炎症如何 影响神经系统疾病的发病机制和治疗。提出了几种方法来实现 这个目标首先，是使用我们新出版的教科书《神经免疫药理学》（第二版）。设计 特别是作为神经科学、免疫学和药理学的课程指南。第二，在发展 跨学科导师培训，为学生提供交叉免疫研究的机会 和神经功能。第三，在系统生物学、细胞信号传导、神经胶质和 神经元生物学、人类疾病模型和突触生理学。这些机会有助于补充 神经遗传学、发育、修复和药理学研究。第四，正式的学生报告 跨学科的基础神经科学家和监督委员会，以获得设计中的研究反馈， 对正在进行的研究活动进行解释和概念化。这是对现有范式的挑战 和现有的学生认知。第五，独特的跨学科团队辅导，教学， 临床神经学经验。第六，是跨学科实习，学生将完成论文 在另一个实验室使用不同的研究方法和导师的组件。第七，坚持 社区、大学和后勤支助。通过协调不同研究小组的培训工作， 通过对神经免疫的共同兴趣联系在一起，学员将加深对先天和 获得性免疫与神经系统疾病的关系这样的学员将更好地准备发展 在疾病病理生物学和人类神经系统治疗干预研究方面取得成功 紊乱