Neuroimmunology of Disease Training Program

摘要 尽管基础神经科学和翻译神经科学研究取得了进展，但新疗法的发展 仍然处于匮乏状态。美国国立卫生研究院已经认识到，有必要将板凳研究转化为 改善人类疾病结果的疗法，并发起了培训能够 有效地将神经疾病过程概念化。一个关键的“有需要的”领域是在 神经免疫力。这一研究领域仍未得到充分的研究，尽管它与猪瘟的病理生物学密切相关。 退化性、感染性、发育性和精神性疾病。为此，我们的培训目标是 为有才华的学生提供对周围和中枢免疫学的基本了解，因为它影响 神经元损伤、分化、再生和保护。该计划旨在为学生提供 广泛接触有助于熟练掌握技术的研究方法。该计划确保了 学生将获得广泛的神经免疫知识。这将允许批判性思维如何炎症 影响神经系统疾病的发病机制和治疗。提出了几种实现以下目标的方法 这个目标。首先，是我们新出版的教材《神经免疫药理学》(第二版)的使用。设计 特别是作为神经科学、免疫学和药理学的课程指南。第二，正在发展中 为学生提供交叉免疫学研究机会的跨学科辅导培训 和神经功能。第三，在系统生物学、细胞信号、神经胶质细胞和 神经生物学、人类疾病模型和突触生理学。这些机会起到补充作用 神经遗传学、发育、修复和药理学研究。第四，是正式的学生报告吗 跨学科的基础神经学家和监督委员会在设计中获得研究反馈， 对正在进行的研究活动进行解释和概念化。这对现有的范式提出了挑战 和现有的学生认知。第五，提供独特的跨学科团队指导、教学和 临床神经学经验。第六，是跨学科实习，学生将完成论文 组件(S)在另一个实验室使用了不同的研究方法和导师。第七，是持续的 社区、大学和后勤支持。通过协调不同研究小组的培训工作 通过神经免疫方面的共同兴趣，学员将加深对先天和 获得性免疫与神经系统疾病的关系。这样的实习生将为发展做好更好的准备 在人类神经系统疾病病理生物学和治疗干预研究方面取得成功 精神错乱。

ABSTRACT Despite advances in basic and translational neuroscience research, the development of new therapeutics remains in want. The National Institutes of Health has recognized the need to translate bench research to therapies that improve human disease outcomes and initiated programs that train researchers who can effectively conceptualize neurological disease processes. One critical “in need” area is in the discipline of neuroimmunity. This research area remains understudied despite its close linkage to the pathobiology of degenerative, infectious, developmental, and psychiatric disorders. To these ends, our training goal is to provide talented students with a fundamental understanding of peripheral and central immunology as it affects neuronal injury, differentiation, regeneration, and protection. The program is designed to provide the student with broad exposure to research methods that facilitate technical proficiency. The program ensures that the student will acquire broad knowledge in neuroimmunity. This would allow critical thinking for how inflammation affects the pathogenesis and treatment of neurological disorders. Several approaches are proposed to achieve this goal. First, is the use of our newly published textbook Neuroimmune Pharmacology (2nd Ed.) designed specifically as a coursework guide in neuroscience, immunology, and pharmacology. Second, is in developing a cross discipline mentorship training to provide the student with opportunities to intersect studies of immunity and neural function. Third, are “unique” research experiences in systems biology, cell signaling, glial and neuronal biology, human disease models and synaptic physiology. These opportunities serve to complement research in neural genetics, development, repair, and pharmacology. Fourth, are formal student presentations to interdisciplinary basic neuroscientists and supervisory committees to acquire research feedback in design, interpretation and conceptualization of ongoing research activities. This serves to challenge existing paradigms and existing student perceptions. Fifth, are uniquely offered cross-discipline team mentoring, teaching, and clinical neurological experiences. Sixth, are cross-disciplinary internships where students will complete thesis component(s) in another laboratory using a different research approach and mentor. Seventh, are sustained community, university and logistical support. By coordinating the training efforts of divergent research groups linked by common interests in neuroimmunity trainees will develop deeper understandings of innate and adaptive immunity in relationship to neurologic disease. Such trainees will be better prepared to develop successful careers in studies of disease pathobiology and therapeutic interventions for human nervous system disorders.