Neuroimmunology of Disease Training Program

疾病神经免疫学培训计划

• 批准号: 10629027
• 负责人: Howard E Gendelman
• 金额: $ 21.39万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629027
• 关键词: Disease; Training Programs; neuroimmunology

ABSTRACT Despite advances in basic and translational neuroscience research, effective therapeutics for neurodegenerative, neuroinflammatory, psychiatric, developmental, and neuroinfectious disorders remain in want. The National Institutes of Health has recognized bench to bedside research to improve disease outcomes and as such initiated programs to train researchers who can conceptualize new disease approaches to aide in effective treatments for neurological disease. One critical “in need” area is neuroimmunity which remains understudied despite its close linkage to the pathobiology of a broad spectrum of neurological disorders. The tradition of training separate groups of students in the disciplines of neuroscience and immunology hinders field growth. Following notable training successes, we seek continuance in training of predoctoral students in studies of neuroimmunology with linkages to neuronal injury, differentiation, regeneration, and protection. The program is designed to train 4 predoctoral students at a time in 1 or 2 year appointments with broad exposures to research methods facilitating best approach, technical, and outcome proficiency. And that each student acquires a broad interdisciplinary field knowledge. This allows for critical thinking in how inflammation affects disease pathogenesis and treatment. Several approaches are proposed to achieve these goals. First, is providing students training opportunities for multidisciplinary studies that intersect immunity and neural function. Second, is the use of our textbook Neuroimmune Pharmacology designed specifically as a guide in the intersections between neuroscience, immunology, and pharmacology. This is taught in our Neuroimmunology course. Third, we will provide a unique conceptual framework to integrate approaches relevant to neuroimmunology research. This contains, but is not limited to, systems biology, cell signaling, glial and neuronal biology, relevant rodent and laboratory models, and synaptic-network physiology. Fourth, are our bi-monthly workshops with student presentations to the program’s neuroscience and immunology faculty and a statistician to acquire feedback in research design, uses and limits of quantitative approaches, statistical interpretations, and conceptualization of ongoing research activities. These are highly interactive, diving into the mechanics of research and complement the formal student research presentations at the program’s annual retreat. Fifth, are clinical neurological experiences to gain the big-picture of a real-world perspective of neurological disease. Sixth, are “cross- disciplinary internships” where students will complete thesis component(s) in another laboratory using a different research approach and mentor. Seventh, are sustained community, university, and logistical support. By coordinating the training efforts of divergent research groups linked by common interests in neuroimmunity, trainees will develop deeper understandings of innate and adaptive immunity in relationship to neurologic disease. Such trainees will be better prepared to develop successful careers in studies of disease pathobiology and therapeutic interventions for human nervous system disorders.

抽象的 尽管基础和转化神经科学研究取得了进展，但有效的治疗方法 神经退行性、神经炎症、精神、发育和神经感染性疾病仍然存在 想。美国国立卫生研究院认可了改善疾病结果的临床研究 因此启动了培训研究人员的计划，他们可以概念化新的疾病方法来帮助 神经系统疾病的有效治疗方法。一个关键的“需要”领域是神经免疫，它仍然存在 尽管它与广泛的神经系统疾病的病理学密切相关，但尚未得到充分研究。这 在神经科学和免疫学学科中对不同学生群体进行培训的传统阻碍了该领域的发展 生长。在取得显着的培训成功之后，我们寻求继续对博士生进行研究培训 神经免疫学与神经元损伤、分化、再生和保护的联系。该计划 旨在在 1 或 2 年的任命中一次培训 4 名博士前学生，让他们广泛接触研究 促进最佳方法、技术和结果熟练程度的方法。并且每个学生都能获得广泛的 跨学科领域知识。这允许对炎症如何影响疾病进行批判性思考 发病机制和治疗。提出了几种方法来实现这些目标。首先，是提供 学生有机会进行免疫和神经功能交叉的多学科研究。第二， 是使用我们专门设计的教科书《神经免疫药理学》作为交叉点的指南 神经科学、免疫学和药理学之间的关系。这是我们的神经免疫学课程中教授的。第三， 我们将提供一个独特的概念框架来整合与神经免疫学研究相关的方法。 这包含但不限于系统生物学、细胞信号传导、神经胶质和神经元生物学、相关啮齿动物 和实验室模型以及突触网络生理学。第四，我们每两个月与学生举办一次研讨会吗？ 向该项目的神经科学和免疫学教师以及统计学家进行演示，以获取反馈 研究设计、定量方法的使用和限制、统计解释以及概念化 正在进行的研究活动。这些是高度互动的，深入研究和补充机制 该项目年度静修会上的正式学生研究报告。五、临床神经病学 获得神经系统疾病现实世界视角的总体经验。六是“跨 学科实习”，学生将使用不同的实验室在另一个实验室完成论文部分 研究方法和导师。第七，持续的社区、大学和后勤支持。经过 协调因神经免疫方面的共同兴趣而联系在一起的不同研究小组的培训工作， 学员将对与神经系统相关的先天性和适应性免疫有更深入的了解 疾病。这些学员将为在疾病病理学研究领域发展成功的职业生涯做好更好的准备 以及人类神经系统疾病的治疗干预。