Quantitative Oncologic PET-MR

定量肿瘤学 PET-MR

• 批准号: 8451303
• 负责人: Georges El Fakhri
• 金额: $ 46.79万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8451303
• 关键词: Abdomen; Air; Anatomy; Animal Model; Animals; Breathing; Cancer Patient; Chemoembolization; Chest; Clinical; Colorectal Cancer; Communities; Data; Detection; Disease; Dose; Event; Fatty acid glycerol esters; Financial compensation; Goals; Gold; Hepatitis Viruses; Hour; Image; Information Theory; Lesion; Liver; Lung; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measures; Medical; Medical Imaging; Metastatic Neoplasm to the Liver; Methods; Metric; Modeling; Monitor; Motion; Musculoskeletal; Noise; Oryctolagus cuniculus; PET/CT scan; Pelvis; Performance; Positron-Emission Tomography; Primary carcinoma of the liver cells; Primates; Radiation; Radiofrequency Interstitial Ablation; Recording of previous events; Recovery; Recurrence; Recurrent disease; Research; Resolution; Scientist; System; Testing; Time; Tissues; Tumor Markers; Woodchuck; attenuation; base; bone; cancer therapy; chemotherapy; experience; human subject; image registration; imaging modality; improved; interest; novel; radiologist; reconstruction; respiratory; response; simulation; soft tissue; statistics; theories; vector

DESCRIPTION (provided by applicant): The goals of this research are to develop novel quantitative methods for simultaneous whole- body (WB) PET-MR imaging, validate these methods in a woodchuck model of spontaneous hepatocellular carcinoma and evaluate their clinical value, compared to PET-CT, in monitoring response to therapy in liver metastases. Simultaneous PET-MR is a novel and promising imaging modality that is generating substantial interest in the medical community and offers the scientific community many challenges and opportunities. Unlike sequentially- acquired WB PET-CT scans, the simultaneous acquisition of MR and PET data can be used to incorporate MR motion and anatomical MR priors within the PET reconstruction model. We hypothesize that the additional MR information will yield substantial improvement of PET in terms of lesion detection and activity estimation. We have formed a multi-disciplinary team that consists of scientists and clinicians to develop quantitative methods for PET-MR and evaluate clinically the improvement that can be achieved over conventional sequential PET-CT.

描述（由申请人提供）：这项研究的目标是为同时全身（WB）PET-MR成像开发新的定量方法，在自发性肝细胞癌的伍德克（Woodchuck）模型中验证这些方法，并评估其临床价值，与PET-CT相比，在监测对肝脏代理治疗的疗法中的临床价值。同时PET-MR是一种新颖而有前途的成像方式，它对医学界产生了重大兴趣，并为科学界提供了许多挑战和机遇。与依次获得的WB PET-CT扫描不同，同时获得MR和PET数据可用于将MR运动和解剖学MR先验纳入PET重建模型中。我们假设额外的MR信息将在病变检测和活性估计方面产生大幅改善PET。我们组成了一个多学科团队，由科学家和临床医生组成，以发展定量 PET-MR的方法，并在临床上评估可以比传统的顺序PET-CT实现的改进。