Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging

我们建议设计、建造和评估正在进行的扫描仪 放射自显影神经断层扫描(SAVANT)，新一代PET扫描仪 利用硬件进步实现人脑的超高分辨率成像 由我们的协作团队成员开发，以实现前所未有的空间 分辨率和计数速率功能。该系统将具有体积分辨率 接近1mm3(各向同性空间分辨率接近1 mm)，约为 比最好的专用脑PET扫描仪好27倍，比 通用PET扫描仪。这样的改进将允许可视化和 对体内生理事件进行前所未有的量化，例如 前驱虫中tau神经原纤维缠结在内嗅皮层的沉积 阿尔茨海默病的分期和多巴胺转运体浓度 黑质和腹侧被盖区。这将允许检测和 在更早的阶段对脑部疾病进行量化，在临床发作前数十年 症状，并允许研究神经递质系统中的关键结构 目前正电子发射计算机断层扫描无法准确成像。建议的高分辨率正电子发射计算机断层扫描 扫描仪将在模体研究中得到验证，并在Health中进行性能评估 志愿者。

We propose to design, build, and evaluate the Scanner Approaching in Vivo Autoradiographic Neuro Tomography (SAVANT), a next generation PET scanner for ultra-high resolution imaging of the human brain using hardware advances developed by members of our collaborative team to achieve unprecedented spatial resolution and count rate capabilities. The system will have a volumetric resolution close to 1 mm3 (isotropic spatial resolution close to 1 mm), which is approximately 27 fold better than the best dedicated brain PET scanners and 125 fold better than general purpose PET scanners. Such an improvement will allow visualization and quantification of in vivo physiological events as never before possible, such as deposition of tau neurofibrillary tangles in the entorhinal cortex in the prodromal stages of Alzheimer's disease and dopamine transporter concentration in the substantia nigra and ventral tegmental area. This will allow the detection and quantitation of brain disease at a much earlier stage, decades before onset of clinical symptoms, and permit the study of key structures in neurotransmitter systems that currently cannot be imaged accurately with PET. The proposed high resolution PET scanner will be validated in phantom studies and performance evaluated in healthy volunteers.