Epidemiologic Field Studies

BCDDP：乳腺癌检测示范项目随访研究（01030）本研究对约6万名乳腺癌示范项目（BCDDP）前参与者进行了随访。目前的分析包括：1)涉及乳腺癌、结肠癌、卵巢癌和肾癌的饮食池项目分析；2)众多的DCEG队列汇集项目。胃癌：随机多干预试验抑制胃癌前病变，山东临朐（00446）我们从中国农村一项8年的试验中收集了15年的随访数据，以确定三种治疗方法是否会影响胃癌发病率或特定的死亡原因。1995 - 2003年长期补充维生素（C、E、硒）和大蒜，1995年一次性服用阿莫西林/奥美拉唑。2012年发表的一篇论文显示，阿莫西林/奥美拉唑治疗在15年期间将胃癌发病率降低了39%。我们最近检查了亚组，并确定抗生素治疗对老年人和研究开始时患有晚期癌前胃病变的患者有效，尽管事实上幽门螺杆菌被认为对早期胃癌发生起作用。因此，抗生素治疗可以广泛应用于预防胃癌，而不必局限于年轻人或轻度组织病理学的人。炎症性乳腺癌（IBC）病例对照研究（00314）这项病例对照研究将包括在北非4个中心（1个在突尼斯和几个私人诊所，2个在埃及，2个在摩洛哥）5年期间积累的约400例IBC病例。包括两个对照组：1)400例非ibc乳腺癌病例；2)随机抽取研究医院女性住院患者（不包括乳腺癌、卵巢癌、子宫内膜癌和鼻咽癌）400例访视对照（一级亲属除外）。该研究包括问卷调查、人体测量、唾液收集、IBC病例乳房的数码照片，以及在选定的中心收集IBC病例和非IBC乳腺癌对照组的石蜡包埋肿瘤组织。该研究是与内布拉斯加州大学联合进行的，表格的开发和翻译由美国国家癌症研究所协调。NCI-DCEG负责在埃及、突尼斯和摩洛哥的研究中心制定研究程序。数据收集工作于2009年3月在埃及开始，2009年8月在突尼斯开始，2011年1月在摩洛哥开始。数据收集资助截止至2013年9月30日。2013年发表的一篇论文讨论了与中低收入国家流行病学研究相关的方法问题。

BCDDP: Breast cancer detection demonstration project follow-up study (01030) This study follows about 60,000 former participants in the Breast Cancer Demonstration Project (BCDDP). Current analyses include: 1) dietary pooling project analyses involving cancers of the breast, colon, ovary, and kidney; and 2) numerous DCEG cohort pooling projects. Gastric cancer: Randomized multi-intervention trial to inhibit precancerous gastric lesions in Linqu, Shandong Province (00446) We gathered fifteen year follow-up data from an 8-year trial in rural China to determine whether any of three treatments would affect gastric cancer incidence or specific causes of mortality. The treatments were long-term vitamin (C, E, and selenium) supplementation and garlic supplementation, given from 1995 to 2003, and one time administration of amoxicillin/omeprazole given in 1995. A paper published in 2012 showed that amoxicillin/omeprazole treatment reduced gastric cancer incidence by 39% over a fifteen year period. We recently examined subgroups and determined that antibiotic treatment was effective for older members of the population and for members with advanced precancerous gastric lesions at the beginning of the study, despite the fact that Helicobacter pylori is thought to act on early stages of gastric carcinogenesis. Thus antibiotic treatment can be applied broadly to prevent gastric cancer and need not be restricted to the young or to those with mild histopathology. Inflammatory breast cancer (IBC) case-control study (00314) This case-control study will include approximately 400 IBC cases accrued over a five-year period at 4 centers in North Africa (1 center in Tunisia plus several private clinics, 2 in Egypt, and 2 in Morocco). Two control groups are being included: 1) 400 non-IBC breast cancer cases and; 2) 400 visitor controls (excluding first-degree relatives) to randomly selected female inpatients (excluding those with breast, ovarian, endometrial, and nasopharyngeal cancer) in the study hospitals. The study involves the administration of a questionnaire, anthropometric measurements, saliva collection, digital photographs of the breasts of IBC cases, and the collection of paraffin-embedded tumor tissue for IBC cases and non-IBC breast cancer controls at selected centers. The study is being conducted as a consortium with the University of Nebraska, with forms development and translation coordinated at the National Cancer Institute-USA. The NCI-DCEG is responsible for developing study procedures at the study centers in Egypt, Tunisia, and Morocco. Data collection began in March 2009 in Egypt, August 2009 in Tunisia, and January 2011 in Morocco. Data collection is funded through 09/30/2013. A paper published in 2013 discussed methodological issues pertinent to an epidemiologic study in middle/low income countries.