Epidemiologic Field Studies

BCDDP：乳腺癌检测示范项目随访研究（1030）本研究跟踪了约6万名乳腺癌示范项目（BCDDP）的前参与者。目前的分析包括：1)体重指数、激素替代疗法和乳腺癌风险；2)乳腺癌组织学类型的危险因素；3)根据乳腺癌ER/PR状态分析危险因素；4)子宫切除术状态、全因死亡率和病因特异性死亡率；5)饮酒与乳腺癌风险；5)涉及乳腺癌、结肠癌、卵巢癌和肾癌的膳食池项目分析；8) DCEG汇集项目，包括非甾体抗炎药和膀胱癌风险。胃癌：随机多干预试验，以抑制胃癌前病变在山东临朐市（446）使用来自中国农村8年试验的数据，我们观察了长期维生素（C， E和硒）和大蒜补充和一次性给予阿莫西林/奥美拉唑对一碳代谢循环中重要因素的影响。长期服用大蒜补充剂可使叶酸增加10%，长期服用维生素和硒补充剂可使谷胱甘肽增加13%。两种补充剂对维生素B12和同型半胱氨酸都没有显著影响，用阿莫西林和奥美拉唑治疗对这些分析没有显著影响。炎性乳腺癌（IBC）试点研究和病例对照研究（314）我们已经完成了在埃及、突尼斯和摩洛哥开展的炎症性乳腺癌病例对照研究的方案、问卷、表格和研究程序，为2008年底开始的培训和数据收集做准备。该研究将包括两年期间在北非4个中心（突尼斯1个中心加上几个私人诊所，埃及2个中心，摩洛哥1个中心）积累的约400例IBC病例。对照组分为两组：1)400例非ibc乳腺癌患者；2)随机抽取研究医院女性住院患者（不包括乳腺癌、卵巢癌、子宫内膜癌和鼻咽癌）400例访视对照（一级亲属除外）。这项研究将包括问卷调查、人体测量、唾液收集、IBC病例乳房的数码照片，以及在选定的中心收集IBC病例和非IBC乳腺癌对照组的石蜡包埋肿瘤组织。该研究将作为一个联合体进行，表格的开发和翻译由美国国家癌症研究所协调。NCI-DCEG负责制定埃及和突尼斯研究中心的研究程序。乳腺癌血清库中乳腺癌和乳腺增生性疾病的风险与遗传基因变异的关系（1100）这项研究在过去一年中一直处于不活跃状态，该研究涉及2636名接受良性乳腺活检的绝经前妇女的随访，这些妇女于1977年至1987年在密歇根州大急流城参加了乳腺癌血清库队列研究。本随访研究的具体目的包括：1)检索和编码绝经前参与者血清库中良性乳腺疾病活检的初始病理报告；2)追踪参与者并与全州癌症登记处和NDI联系，以确定乳腺癌病例；3)在特异性目标1（如上）中检索和编码后，发现患有乳腺癌风险相当高的良性乳腺疾病诊断的参与者，或在特异性目标2中追踪后发现在随访期间患有乳腺癌的参与者，并选择匹配的对照组进行基因分型。每项具体目标的进展情况：1)正在寻找的2632份病理报告中，有2184份已从大急流城的医院取回。2)所有参与者先前已提交给养老金福利信息（PBI）以确定生命状态，而推定活着的人与TransUnion数据库进行匹配以确认其社会安全号码（SSN），而推定死亡的人则提交给国家死亡指数（NDI）加死因确定。通过与NDI和密歇根州癌症登记处的匹配，以及最初的后续调查问卷的结果，得出了186名患有乳腺癌的独特女性。3)具体目标3的试点研究已经完成。从12个样本标本中提取DNA，并在ATCC-Frederick合同实验室对两种遗传变异进行基因分型。

BCDDP: Breast cancer detection demonstration project follow-up study (1030) This study follows about 60,000 former participants in the Breast Cancer Demonstration Project (BCDDP). Current analyses include: 1) body mass index, hormone replacement therapy and breast cancer risk; 2) risk factors for histologic types of breast cancer; 3) risk factors according to breast cancer ER/PR status; 4) hysterectomy status and all-cause and cause-specific mortality; 5) alcohol consumption and breast cancer risk; 5) dietary pooling project analyses involving cancers of the breast, colon, ovary, and kidney; and 8) DCEG pooling projects, including NSAIDS and bladder cancer risk. Gastric cancer: Randomized multi-intervention trial to inhibit precancerous gastric lesions in Linqu, Shandong Province (446) Using data from an 8-year trial in rural China, we looked at the effects of long-term vitamin (C, E, and selenium) and garlic supplementation and one time administration of amoxicillin/omeprazole on factors important in the one-carbon metabolic cycle. Long-term administration of garlic supplements increased folate by 10%, and long-term administration of the vitamin and selenium supplement increased glutathione by 13%. Neither supplement had a significant effect on vitamin B12 or homocysteine, and the treatment with amoxicillin and omeprazole had no significant effects on any of these analytes. Inflammatory breast cancer (IBC) pilot study and case-control study (314) We have finalized the protocol, questionnaire, forms, and study procedures for a case-control study of inflammatory breast cancer in Egypt, Tunisia, and Morocco in preparation for the training and start of data collection in late 2008. The study will include approximately 400 IBC cases accrued over a two-year period at 4 centers in North Africa (1 center in Tunisia plus several private clinics, 2 in Egypt, and 1 in Morocco). Two control groups will be included: 1) 400 non-IBC breast cancer cases and; 2) 400 visitor controls (excluding first-degree relatives) to randomly selected female inpatients (excluding those with breast, ovarian, endometrial, and nasopharyngeal cancer) in the study hospitals. The study will involve the administration of a questionnaire, anthropometric measurements, saliva collection, digital photographs of the breasts of IBC cases, and the collection of paraffin-embedded tumor tissue for IBC cases and non-IBC breast cancer controls at selected centers. The study will be conducted as a consortium, with forms development and translation coordinated at the National Cancer Institute-USA. The NCI-DCEG is responsible for developing study procedures at the study centers in Egypt and Tunisia. Risk of breast cancer and hyperplastic breast conditions in the breast cancer serum bank in relation to inherited genetic variants (1100) This study, which has been inactive for the past year, involves follow-up of 2636 premenopausal women who received a benign breast biopsy and were enrolled in the Breast Cancer Serum Bank cohort study in Grand Rapids, MI, from 1977 through 1987. The specific aims of this follow-up study include: 1) retrieval and coding of the initial pathology report pertaining to the benign breast disease biopsy received by premenopausal participants in the serum bank; 2) tracing of participants and linkage to statewide cancer registries and the NDI to identify breast cancer cases; 3) genotyping of participants who are found, after the retrieval and coding in Specific Aim 1 (above), to have benign breast disease diagnoses that confer a considerably elevated risk of breast cancer, or those who are found, after tracing in Specific Aim 2, to have developed breast cancer during follow-up, and selected matched controls. Progress on each specific aim: 1) 2184 out of a total of 2632 pathology reports being sought have been retrieved from hospitals in Grand Rapids. Pathology report collection is now considered completed 2) all participants had previously been submitted to Pension Benefit Information (PBI) for vital status determination, while those presumed living were matched against the TransUnion database to confirm their social security number (SSN), and those who were presumed deceased were submitted to the National Death Index (NDI) plus for cause of death determination. The match with the NDI and with the Michigan State Cancer Registry, together with results from the original follow-up questionnaires, yielded 186 unique women with breast cancer. 3) pilot studies have been completed for Specific Aim 3. DNA was extracted from 12 sample specimens and genotyped for two genetic variants by ATCC-Frederick contract laboratories.