CRANBERRY-AMOXICILLIN INTERACTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。蔓越莓汁是一种广泛使用的“民间疗法”，以预防和治疗尿路感染（UTIs），尽管其疗效的证据有限。对于预防尿路感染，有限数量的相互矛盾的数据表明，蔓越莓汁有可能的疗效，基于最近的科克伦审查的临床研究。关于蔓越莓汁治疗尿路感染的疗效需要进一步的信息;其疗效需要与阿莫西林（一种常用的治疗方法）联合评估。目前的建议集中在假设蔓越莓汁成分或其副产品产生的全身代谢干扰肠道和肾脏运输的β-内酰胺抗生素（阿莫西林），这可能会导致减少输出的抗生素在尿液中伴随着改变其疗效治疗尿路感染。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cranberry juice is a widely used "folk remedy" to prevent and treat urinary tract infections (UTIs) in spite of limited evidence of its efficacy. For prevention of UTIs, the limited amount of conflicting data suggests that cranberry juice has possible efficacy based on the clinical studies reviewed in a recent Cochrane Review. Further information is needed regarding the efficacy of cranberry juice in the treatment of UTIs; its efficacy will need to be evaluated in combination with Amoxicillin, a commonly used treatment. The present proposal focuses on the hypothesis that cranberry juice ingredients or its byproducts arising from systemic metabolism interfere with the intestinal and renal transport of -lactam antibiotics (amoxicillin), which result in a diminished output of the antibiotics in urine with perhaps an attendant change in its efficacy treatment of UTIs.