CRANBERRY-AMOXICILLIN INTERACTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。蔓越莓汁是一种被广泛应用于预防和治疗尿路感染(UTIs)的民间药物，尽管其疗效的证据有限。在预防尿路感染方面，有限数量的相互矛盾的数据表明，根据最近发表在Cochrane评论中的临床研究，小红莓汁可能具有疗效。关于蔓越莓汁治疗尿路感染的疗效还需要进一步的信息；其疗效需要与阿莫西林(一种常用的治疗方法)相结合进行评估。目前的建议侧重于这样一种假设，即蔓越莓汁成分或其全身代谢产生的副产品干扰内酰胺类抗生素(阿莫西林)的肠道和肾脏转运，从而导致尿液中抗生素产量减少，可能伴随着其治疗尿路感染的疗效的改变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cranberry juice is a widely used "folk remedy" to prevent and treat urinary tract infections (UTIs) in spite of limited evidence of its efficacy. For prevention of UTIs, the limited amount of conflicting data suggests that cranberry juice has possible efficacy based on the clinical studies reviewed in a recent Cochrane Review. Further information is needed regarding the efficacy of cranberry juice in the treatment of UTIs; its efficacy will need to be evaluated in combination with Amoxicillin, a commonly used treatment. The present proposal focuses on the hypothesis that cranberry juice ingredients or its byproducts arising from systemic metabolism interfere with the intestinal and renal transport of -lactam antibiotics (amoxicillin), which result in a diminished output of the antibiotics in urine with perhaps an attendant change in its efficacy treatment of UTIs.