CRANBERRY-AMOXICILLIN INTERACTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。蔓越莓汁是一种广泛使用的“民间偏方”，用于预防和治疗尿路感染（uti），尽管证据有限。在预防尿路感染方面，有限的相互矛盾的数据表明，基于最近Cochrane综述中回顾的临床研究，蔓越莓汁可能具有功效。关于蔓越莓汁治疗尿路感染的功效，需要进一步的信息；它的疗效需要与阿莫西林（一种常用的治疗方法）联合进行评估。目前的建议侧重于这样一种假设，即蔓越莓汁成分或其全身代谢产生的副产物干扰了-内酰胺类抗生素（阿莫西林）的肠道和肾脏运输，这导致尿中抗生素的输出减少，可能伴随其治疗尿路感染的疗效发生变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cranberry juice is a widely used "folk remedy" to prevent and treat urinary tract infections (UTIs) in spite of limited evidence of its efficacy. For prevention of UTIs, the limited amount of conflicting data suggests that cranberry juice has possible efficacy based on the clinical studies reviewed in a recent Cochrane Review. Further information is needed regarding the efficacy of cranberry juice in the treatment of UTIs; its efficacy will need to be evaluated in combination with Amoxicillin, a commonly used treatment. The present proposal focuses on the hypothesis that cranberry juice ingredients or its byproducts arising from systemic metabolism interfere with the intestinal and renal transport of -lactam antibiotics (amoxicillin), which result in a diminished output of the antibiotics in urine with perhaps an attendant change in its efficacy treatment of UTIs.