Computer-based MI to engage smokers living with HIV in tobacco quitline treatment

基于计算机的 MI 让感染艾滋病毒的吸烟者参与戒烟热线治疗

基本信息

批准号：
8467102
负责人：
RICHARD A BROWN
金额：
$ 32.85万
依托单位：
BUTLER HOSPITAL (PROVIDENCE, RI)
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8467102
关键词：
Abstinence Accounting Cardiovascular Diseases Cardiovascular system Caring Cessation of life Cigarette Smoker Clinical Research Communities Computers Counseling Data Development Dietary Intervention Disease Effectiveness Feedback General Population Geographic state Goals HIV Health Health Benefit Health Personnel Highly Active Antiretroviral Therapy Hour Individual Intervention Interview Knowledge Life Link Lung Lung diseases Meta-Analysis Modification Morbidity - disease rate Outcome Participant Patient Self-Report Patients Prevalence Process Public Health Publishing Randomized Controlled Trials Readiness Relative (related person)Reporting Research Research Personnel Resources Risk Risk Behaviors Scientific Advances and Accomplishments Self Efficacy Smoke Smoker Smoking Smoking Cessation Intervention Smoking and Health Research Telephone Testing Time Tobacco Tobacco use Training Treatment Efficacy Withholding Treatment Work base brief intervention cigarette smoking cohort cost cost effective follow-up health related quality of life innovation interest mortality motivational intervention nicotine patch non-smoking nutrition nutrition education post intervention programs prototype public health relevance quitline satisfaction smoking cessation

项目摘要

DESCRIPTION (provided by applicant): The prevalence of cigarette smoking among people living with HIV (PLWH) in the U.S. is estimated at 40-70%, as the smoking rate in the general population has declined to 20.6%. Tobacco use has significant health consequences for PLWH, accounting for nearly 25% of all deaths in a multinational cohort of PLWH who used highly active antiretroviral therapy (HAART). Interactions among tobacco, the HIV virus, and HAART render PLWH who smoke even more susceptible than smokers without HIV to cardiovascular and lung diseases, and also increases their risk for a multitude of HIV-related illnesses. Against this backdrop, very little research on smoking cessation interventions for PLWH has been published, and none has evaluated approaches that could be easily disseminated and integrated into standard HIV care. The long-term goal of this program of research is to disseminate an effective, brief computer-based intervention that can be readily integrated into HIV treatment settings to motivate tobacco quitline use among smokers living with HIV. The overall objective of this application is to develop this computer intervention, modify it based on initial piloting and feedback, and obtain preliminary data supporting the efficacy of the intervention. This will be accomplished by pursuing three specific aims: 1) to develop and conduct preliminary pilot testing (n=16) of a brief, computer- based intervention intended to motivate tobacco quitline use among cigarette smokers living with HIV (CI- METQ; Computer Intervention to Motivate Engagement in Tobacco Quitline treatment) and to develop and pilot (n=4) a computer-based, time matched nutrition education for PLWH control intervention (NC) equated for the offer of a tobacco quitline referral and 8 weeks of free nicotine patch for those who engage in quitline treatment, 2) to conduct a preliminary smoking cessation RCT with 100 PLWH, comparing CI-METQ vs. NC, with predictions that CI-METQ relative to NC will result in increased readiness, higher rates of tobacco treatment engagement, more quit smoking attempts and higher rates of 7-day point prevalence abstinence rates at 1-, 3- and 6-month follow-ups. Health-related quality of life over this period will also be examined, and 3) to examine CI-METQ's effects on key mechanisms during the computer session and their associations with tobacco treatment engagement and smoking outcomes at 1-, 3- and 6-month follow-ups. The research proposed is innovative in that: 1) no previous studies have implemented a computer-based motivational intervention targeting tobacco use in PLWH, 2) the CI-METQ proposed in this application is focused on promoting tobacco treatment engagement rather than smoking cessation, per se, and 3) no previous studies have attempted to link PLWH smokers with free tobacco quitlines, an efficacious and readily available resource. The CI-METQ will have potential for broad reach within HIV treatment settings and if effective, will have significant overall impact in reducing smoking-related morbidity and mortality and in advancing scientific knowledge regarding the use of brief, computer interventions to change health risk behaviors in PLWH.

描述（由申请人提供）：美国艾滋病毒（PLWH）患者中吸烟的流行率估计为40-70％，因为一般人群的吸烟率下降到20.6％。烟草使用对PLWH有重大的健康后果，占使用高度活性抗逆转录病毒疗法（HAART）的跨国PLWH中所有死亡人数的近25％。烟草，HIV病毒和Haart的相互作用比没有HIV的吸烟者对心血管和肺部疾病更容易吸烟，并且增加了与HIV相关疾病的风险。在这种背景下，已经发布了有关PLWH的戒烟干预措施的很少的研究，并且没有人评估可以轻松传播并整合到标准HIV护理中的方法。该研究计划的长期目标是传播一种有效的，简短的基于计算机的干预措施，可以容易地将其整合到HIV治疗环境中，以激励患有艾滋病毒的吸烟者中的烟草Quitline使用。该应用程序的总体目的是开发此计算机干预，根据初始试验和反馈对其进行修改，并获得支持干预功效的初步数据。这将通过追求三个具体目的来实现：1）基于简短的基于计算机的干预措施开发和进行初步的试点测试（n = 16），旨在激励HIV的吸烟者中的烟草使用烟草（CI-MetQ；计算机干预；计算机干预，以激发烟草Quitline治疗的互动，以开发烟草的努力和PLET基于计算机（N = 4），n = 4 = 4 = 4 = 4）（NC）等同于提供烟草的戒烟转介和为那些进行戒烟治疗的人提供8周的免费尼古丁补丁，2）与100 pl WH进行初步的戒烟RCT，比较CI-METQ与NC相比，与NC相比，与NC相对于NC相对于NC的较高率和更高的速率率会导致7月份的吸烟速率，而较高的速率会增加，则可以增加速率，以增加速率，以更高的速度进行viression for Adve，to-giat oversive of to ncips of tossive goits for Advections for to tobacco的率更高的速率，ci-metq copection to-gacco的率会增加，这是ci-metq的率。在1个，3个月和6个月的随访中的戒酒率。还将检查与健康相关的生活质量，以及3）检查CI-METQ在计算机会议期间对关键机制的影响及其与1、3和6个月随访的烟草治疗参与和吸烟结果的关联。提出的这项研究具有创新性：1）以前的研究没有实施针对PLWH中烟草使用的基于计算机的动机干预措施，2）此应用中提出的CI-METQ的重点是促进烟草治疗的参与，而不是吸烟，而不是吸烟，本身和3）以前的研究没有尝试将吸烟与Pl pl smofient tobacco cobility和Quittione Nose and Fircition和Profic nosity Nose nose forical nose forical nose nose nose。 CI-METQ将在HIV治疗环境中具有广泛影响力的潜力，如果有效，将对降低吸烟相关的发病率和死亡率以及有关使用简短的计算机干预来改变PLWH中的健康风险行为的科学知识具有重大影响。