Linking Brain and Behavior in Chronic Tic Disorder

将慢性抽动障碍的大脑与行为联系起来

• 批准号: 8584233
• 负责人: Sandra K Loo
• 金额: $ 24.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8584233
• 关键词: 12 year old; 14 year old; Address; Age; Anterior; Area; Base of the Brain; Behavior; Behavior Therapy; Biological Markers; Biomedical Research; Blinking; Body Image; Brain; Child; Chronic; Clinical; Collaborations; Comorbidity; Complex; Computer software; Corpus striatum structure; Coupling; Data; Data Analyses; Data Collection; Development; Diagnosis; Electroencephalography; Electromyography; Environment; Etiology; Event; Exhibits; Fingers; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Generations; Genetic; Gilles de la Tourette syndrome; Habits; Individual; Involuntary Movements; Link; Magnetic Resonance Imaging; Medial; Mediating; Modeling; Monitor; Morphologic artifacts; Motion; Motor; Motor Cortex; Movement; Muscle; Muscle Tension; Parietal; Pattern; Pharmaceutical Preparations; Play; Population; Production; Regulation; Relative (related person); Research; Resolution; Rewards; Role; Sample Size; Sampling; Scanning; Source; Stream; Structure; Technology; Testing; Tic disorder; Training; United States National Institutes of Health; Youth; aged; base; brain behavior; developmental disease; endophenotype; imaging modality; indexing; innovation; millisecond; neural circuit; neural model; neurobiological mechanism; novel strategies; peer; public health relevance; relating to nervous system; response; treatment effect

DESCRIPTION (provided by applicant): The neural circuitry underlying tic production and suppression is particularly important given the role of voluntary tic control in empirically supported behavioral treatments such as Habit Reversal Training (HRT) for individuals with Chronic Tic Disorders (CTDs), including those with Tourette's Syndrome. Despite a building research base, the etiology and pathophysiology of CTDs remain poorly understood, with existing findings confounded by small sample sizes, developmental effects due to wide age range, medication usage, and uncontrolled psychiatric comorbidity. In response to the NIH R21 call for exploratory or developmental research that have the potential to advance biomedical research, we propose to apply an innovative approach (mobile brain/body imaging [MoBI] to characterizing the neural substrates underlying movement and urge suppression in CTDs. The MoBI approach involves the simultaneous recording and integration of high-definition motion capture video, cortical activity (electroencephalography; EEG) and muscle movements (electromyography; EMG). Use of this leading edge technology will advance our understanding of the neural substrates underlying movement initiation and urge suppression and may allow identification of putative biomarkers for tic generation and suppression. The current study proposes to use the MoBI approach on a sample of 48 children aged 8-12 years old, 24 with CTDs and 24 age-matched typically developing (TD) peers. We will use several paradigms to model the neural substrates underlying voluntary and involuntary movements and test whether CTDs involve quantitative or qualitative deviation in motor network circuitry relative to TD peers. Successful application of the MoBI approach to the problem of discovering and testing brain-based biomarkers for CTD is highly innovative in the context of current research, and also has clear potential for advancing clinical CTD research and practice.

描述（由申请人提供）：考虑到自愿抽动控制在经验支持的行为治疗中的作用，例如慢性抽动障碍（CTD）患者（包括抽动秽语综合征患者）的习惯维持训练（HRT），抽动产生和抑制的神经回路特别重要。尽管建立了研究基础，但对CTD的病因学和病理生理学仍然知之甚少，现有的研究结果受到小样本量、广泛年龄范围引起的发育影响、药物使用和不受控制的精神病合并症的混淆。为了响应NIH R21对具有推进生物医学研究潜力的探索性或发展性研究的呼吁，我们建议应用一种创新方法（移动的脑/体成像[MoBI]）来表征CTD中运动和冲动抑制的神经基质。MoBI方法涉及同时记录和整合高清运动捕捉视频、皮层活动（脑电图; EEG）和肌肉运动（肌电图; EMG）。使用这种前沿技术将推进我们对运动启动和冲动抑制的神经基质的理解，并可能允许鉴定抽动产生和抑制的推定生物标志物。目前的研究建议使用的MoBI方法的样本48名8-12岁的儿童，24与CTD和24年龄匹配的典型发展（TD）的同龄人。我们将使用几种范式来模拟自愿和不自愿运动的神经基质，并测试CTD是否涉及相对于TD同龄人的运动网络电路的定量或定性偏差。 MoBI方法成功应用于发现和测试CTD的脑生物标志物的问题，在当前研究的背景下具有高度创新性，并且对于推进临床CTD研究和实践具有明显的潜力。