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Developing Optimal Dynamic Behavioral Intervention in Community-Based Studies.

在基于社区的研究中制定最佳动态行为干预。

基本信息

批准号：
8462308
负责人：
Ken Cheung
金额：
$ 27.19万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8462308
关键词：
Address Advocate Base Sequence Behavior Therapy Behavioral Blood Pressure Cause of Death Characteristics Clinical Trials Design Communities Computer Simulation Computer software Data Data Analyses Education Educational Curriculum Equation Family Family member Goals Health Hybrids Individual Intervention Intervention Studies Learning Life Style Literature Measures Methodology Methods Modeling Noise Outcome Participant Patients Physical activity Prevention program Psychological reinforcement Public Health Publications Randomized Research Risk Factors Risk Reduction Self Management Social support Staging Statistical Methods Stroke Stroke prevention Techniques Time base clinical application computer science design disability innovation intervention effect intervention program medication compliance model development novel patient population prevent programs randomized trial theories treatment program

项目摘要

DESCRIPTION (provided by applicant): Stroke prevention may be achieved through lifestyle changes on a variety of issues such as physical activities and medication adherence. It is therefore difficult to overstate the importance of developing and disseminating behavioral intervention programs as a public health measure to prevent strokes. For the same reason, a behavioral intervention program naturally involves multiple components addressing the various issues; and a successful multi-component program is likely a direct result of administering each interventional component in an optimal sequence, based on the intermediate health outcomes, so as to maximize the eventual health outcome such as blood pressure reduction over 12 months. This type of treatment program tailors the intervention sequence according to an individual's own characteristics, and is sometimes called dynamic treatment regime (DTR). This research aims to develop, validate, and disseminate statistical methods to identify optimal DTR through carefully designed randomized community-based studies. We plan to achieve this research goal in four steps. First, we will develop a data analytical technique, called Q-learning, that will enable us to identify an optimal DTR in an unbiased fashion using data from community- based studies. Q-learning is a cutting-edge technique originating from the computer science literature; this research will adapt this innovative idea to clinical applications where data are observed with high level of variability (noise). Second, we will develop statistical designs that facilitate the discovery of optimal DTR through Q-learning while benefiting the trial participants. This will involve novel synthesis of two clinical trial design concepts: sequential multiple assignment randomized trial (SMART) and adaptive randomization (AR). Third, we will validate the proposed theory and methods by using computer simulation and analyzing data from an actual behavioral intervention study. Fourth, we will disseminate the methods by building software with public access and employ the methods in the planning of the next stage of intervention study; this step is intended to close the lag time between novel methods and its clinical applications. Our long-term public health goal is to enhance the capability of developing optimal behavioral intervention curriculums.

描述（由申请人提供）：中风预防可以通过改变生活方式来实现，如身体活动和药物依从性。因此，很难夸大发展和传播行为干预计划作为预防中风的公共卫生措施的重要性。出于同样的原因，行为干预计划自然涉及解决各种问题的多个组件;成功的多组件计划可能是基于中间健康结果以最佳顺序管理每个干预组件的直接结果，以便最大限度地提高最终的健康结果，例如在12个月内降低血压。这种类型的治疗方案根据个人自身的特点调整干预顺序，有时称为动态治疗方案（DTR）。本研究旨在开发，验证和传播统计方法，以确定最佳的DTR通过精心设计的随机社区为基础的研究。我们计划分四步实现这一研究目标。首先，我们将开发一种数据分析技术，称为Q学习，这将使我们能够使用基于社区的研究数据以公正的方式确定最佳DTR。Q-learning是一种源自计算机科学文献的尖端技术;这项研究将使这一创新理念适用于临床应用，其中观察到的数据具有高度的可变性（噪声）。其次，我们将开发统计设计，通过Q学习促进发现最佳DTR，同时使试验参与者受益。这将涉及两种临床试验设计概念的新合成：序贯多分配随机试验（SMART）和自适应随机化（AR）。第三，我们将通过计算机模拟和分析实际行为干预研究的数据来验证所提出的理论和方法。第四，我们将通过建立公共访问软件来传播这些方法，并将这些方法用于下一阶段干预研究的规划;这一步骤旨在缩短新方法与其临床应用之间的滞后时间。我们的长期公共卫生目标是提高发展最佳行为干预机构的能力。