Marijuana and Sleep in Young Adults

描述(由申请人提供)：18岁至29岁的年轻人报告过去一个月吸食大麻的比率最高。年轻人睡眠障碍的发生率也很高，可能会影响醒着时的功能：学习、工作、认知和社交功能、情绪和驾驶风险。有证据表明，MJ与睡眠障碍有关，这使得MJ和睡眠之间的关系成为一个具有重大公共卫生意义的主题。尚未研究MJ使用和睡眠干扰对一系列MJ使用频率的白天功能的影响，也没有研究社区年轻人主观睡眠报告与客观睡眠测量之间的关系。几乎所有关于MJ和睡眠的对照研究都是在研究MJ戒断的背景下进行的，实验室多导睡眠图被用来描述在停止大量使用MJ期间的睡眠障碍。然而，大多数年轻的成年MJ使用者并不是重度使用者，很少有人寻求以戒除为目标的正式药物滥用治疗。因此，尽管MJ的使用影响睡眠，但在社区中最常见的MJ使用水平上，MJ和睡眠之间的关系仍未得到研究。80名MJ使用者和20名不使用MJ的人，在没有和没有睡眠干扰的情况下，将接受基线评估，随后将接受21天的活动和睡眠日记，其中包括通过日常电话接触收集的白天功能测量，最后的面谈评估将在第22天进行。本研究的具体目的是：1)调查18-29岁吸食大麻的年轻人的睡眠障碍，并与不吸食MJ的对照组进行比较。2)调查吸食MJ的人的睡眠障碍与日间功能的相互关系，并与不吸食MJ的人进行比较。量化MJ与睡眠障碍的关系可以为制定干预策略提供数据，例如公共卫生活动，以提高人们对MJ使用这种具有临床意义的后果的认识。它还将推动初级保健和精神卫生提供者在与MJ使用者的接触点讨论MJ-睡眠联系。

DESCRIPTION (provided by applicant): Young adults between the ages of 18 and 29 report the highest rate of past month marijuana (MJ) use. Young adults also have high rates of sleep disturbance that can affect wake-time functioning: school, work, cognitive and social functioning, mood, and driving risk. Evidence suggesting that MJ is associated with sleep disturbance makes the relationship between MJ and sleep a subject of major public health significance. The effects of MJ use and sleep disturbance on daytime functioning across a range of MJ use frequency has not been studied, nor has the relationship of subjective sleep reports to objective measures of sleep in community- based young adults. Nearly all controlled studies of MJ and sleep have occurred in the context of studying MJ withdrawal where laboratory polysomnography has been used to describe sleep disturbance during discontinuation of heavy MJ use. Yet most young adult MJ users are not heavy users, and few seek formal substance abuse treatment with a goal of abstinence. Thus, although MJ use impacts sleep, the relationship between MJ and sleep remains unstudied at the MJ use levels most common in the community. Eighty MJ users and twenty MJ nonusers, without and without sleep disturbance, will receive a baseline assessment followed by 21-days of actigraphy and sleep diaries that include measures of daytime function collected via daily phone contact, with a final interview assessment on day 22. The Specific Aims of this study are: 1) To investigate sleep disturbance among young adults aged 18-29 who use marijuana and compare with a control group of MJ nonusers 2) To investigate the interrelationships between sleep disturbance and daytime functioning among MJ users and compare with MJ nonusers Quantifying the relationship between MJ and sleep disturbance in young adults can provide data that can help formulate intervention strategies, such as public health campaigns to increase awareness of this clinically meaningful consequence of MJ use. It would also provide impetus for primary care and mental health providers to discuss the MJ-sleep connection at the point of contact with MJ users.