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PRC Project--Butters

PRC Project--Butters
PRC项目--巴特斯
批准号：
8465286
负责人：
MERYL A BUTTERS
金额：
$18.24万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8465286
关键词：
AdherenceAdultAnxietyBiological MarkersBlood VesselsButterCaregiversChildChronicCognitiveCommunitiesCommunity NetworksComorbidityCompetenceDementiaDoctor of MedicineDoctor of PhilosophyEffectivenessElderlyEnrollmentFriendsGenotypeHormonesImpaired cognitionIncidenceIndividualInflammatoryInterventionLifeLinkMajor Depressive DisorderManualsMeasuresMediatingMedicalMental DepressionModelingNerve DegenerationOutcomePathologicPreventionProblem SolvingProceduresPsychosocial FactorRandomizedRiskRoleSiblingsSocial supportSpousesStagingStandardizationStressToxic effectTrainingcognitive functioncytokinedepression preventiongeriatric depressionimprovedinstrumental activity of daily livingmembermild cognitive impairmentneuroinflammationpreventprobandproblem solving therapystressortherapy developmenttreatment as usual

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中文摘要
翻译
轻度认知功能障碍（MCI）是介于正常认知功能和痴呆之间的一种过渡状态。抑郁症经常与MCI同时发生，每一种都会增加发展另一种的风险。（192-196）认知丧失可能是一种应激源（就像任何慢性和潜在的进行性医学疾病一样），与一系列与抑郁风险增加有关的心理社会因素有关。（197199）一旦老年人发展为重度抑郁症，多种病理机制（即，血管、神经变性、应激激素毒性（200-201）可能由神经炎症介导，增加认知能力下降的风险（在抑郁症的情况下，进展为痴呆的风险增加一倍）。（二百零二）
英文摘要
Mild cognitive impairment (MCI) is a transitional state between normal cognitive function and dementia. Depression frequently co-occurs with MCI and each increases the risk of developing the other.(192-196) Cognitive loss may act as a stressor (much like any chronic and potentially progressive medical illness), associated with a constellation of psychosocial factors that have been linked to increased depression risk.(197199) Once older adults develop major depression, multiple pathologic mechanisms (i.e., vascular, neurodegenerative, stress hormone toxicity(200-201) likely mediated by neuroinflammation, increase the risk of cognitive decline (in the case of depression risk of progression to dementia is doubled).(202)
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Major Depression and Molecular Senescence: The Role of Sleep
3/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depression
3/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depression
3/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depression
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