Overall

全面的

• 批准号: 8741082
• 负责人: GABRIELE BERGERS
• 金额: $ 42.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8741082
• 关键词: Brain Neoplasms; Brain Pathology; Cancer Biology; Communities; Engineering; Environment; Glioma; Goals; Image; Knowledge; Measurement; Mission; Molecular; Neurosciences; Operative Surgical Procedures; Radiology Specialty; Research; Research Personnel; Resources; Science; Scientist; Testing; Tissues; Work; base; brain cell; cost; novel; novel strategies; tool; tumor microenvironment

The mission of our U54 entitled "Biophysical and molecular dialogue of glioma cells and the brain microenvironment" is to bring together experts from basic neurosciences, cancer biology, engineering, radiology, imaging, brain pathology, and surgery, and, as a team within the Center and within the national TMEN network, support and nurture an interdisciplinary environment and research that: (1) originates and tests novel, interdisciplinary-sciences based approaches to understanding, controlling and treating aggressive brain tumors; (2) generates orthogonal sets of physical and molecular measurements and integrates them with existing knowledge on brain tumors from the perspective of the tumor microenvironment; (3) develops and evaluates molecular and physical approaches to provide a comprehensive and dynamic picture of brain tumors that define the tissue microenvironment of high-grade gliomas; (4) disseminates these novel approaches and tools throughout the TMEN network and the larger scientific community; (5) exploits resources and scientific expertise within the UCSF scientific community; (6) leverages, efficiently and cost-effectively, existing NCI resources, both locally and nationally; and (7) educates the public and scientists at all levels (undergraduate to senior investigators) about the work and goals of the TMEN.

我们的U 54的使命题为“胶质瘤细胞和大脑的生物物理和分子对话 微环境”是汇集来自基础神经科学，癌症生物学，工程学， 放射学，成像，脑病理学和外科，以及作为中心内和国家内的团队 TMEN网络，支持和培育跨学科的环境和研究， (1)发起和测试新的，跨学科的科学为基础的方法来理解，控制和 治疗侵袭性脑肿瘤; (2)生成正交的物理和分子测量集，并将它们与现有的 从肿瘤微环境的角度了解脑肿瘤; (3)开发和评估分子和物理方法，以提供全面和动态的 脑肿瘤图片，定义了高级别胶质瘤的组织微环境; (4)在整个TMEN网络和更大的科学网络中传播这些新的方法和工具。 社区; (5)利用UCSF科学界的资源和科学专业知识; (6)有效和具有成本效益地利用地方和国家现有的NCI资源;以及 (7)教育公众和各级科学家（本科生到高级研究人员）了解这项工作， TMEN的目标