Optimization of IsoRaft Technology for Stem Cell Market

针对干细胞市场的 IsoRaft 技术优化

• 批准号: 8515625
• 负责人: Nicholas Carl Dobes
• 金额: $ 15.14万
• 依托单位: CELL MICROSYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8515625
• 关键词: Address; Adoption; Area; Asia; Biological; Biological Assay; Biological Sciences; Biology; Biotechnology; Cell Count; Cell Culture Techniques; Cell Separation; Cells; Clinical; Colony-Forming Units Assay; Communities; Computer software; Cultured Cells; Development; Devices; Disease; Disease Progression; Drug Industry; Encapsulated; Epigenetic Process; Epithelial; Europe; Extracellular Matrix; Feedback; Functional disorder; Generations; Goals; Growth; Health; Image; In Vitro; Individual; Industry; Institution; Intestines; Investments; Licensing; Manuals; Marketing; Medicine; Methods; Mission; Monitor; North Carolina; Phase; Population; Preclinical Drug Evaluation; Process; Protocols documentation; Publications; Regenerative Medicine; Research; Research Institute; Research Personnel; Retrieval; Sample Size; Scanning; Small Business Innovation Research Grant; Solid; Sorting - Cell Movement; Stem Cell Research; Stem cells; Surface; Technology; Testing; Time; Tissue Sample; Translations; United States National Institutes of Health; Universities; adult stem cell; base; cellular imaging; cost; design; drug discovery; embryonic stem cell; flexibility; forest; interest; medical schools; microsystems; novel; novel strategies; physical separation; professor; programs; prototype; public health relevance; research study; stem cell technology; success; technology development

DESCRIPTION (provided by applicant): Cell Microsystems is a North Carolina-based start-up biotechnology company whose mission is to commercialize a novel, yet affordable, platform for the efficient isolation of viable, single cells or colonies from a mixed population while the cell/colony remains adherent or encapsulated to a solid surface. The company's "IsoRaft" technology is based on a unique cell array recently developed at the University of North Carolina (UNC) at Chapel Hill, and represents an ideal opportunity for the translation of an academic technology to the marketplace through the SBIR program. Cell Microsystems has obtained license from UNC to commercialize the technology for a broad market in academic labs, as well as in the biotechnology and pharmaceutical industries. The products consist of disposable microarray (the IsoRaft Array) for culturing cells and a simple device for isolating the cell/colony of interest. Prototypes of arrays and devices have been completed and are being tested in a number of academic labs as an Early Adoption Program (EPA) at nearby research institutes. In this Phase I SBIR proposal, we will explore the feasibility of using the IsoRaft technology for stem cell research. Particularly we will focus on design and optimize the IsoRaft Array for stem cells, and develop strategies for cell imaging, identification, tracking and retrievl of targeted stem cells/colonies. The use IsoRaft technology for stem cell research will be conducted by our academic collaborator at UNC School of Medicine. Our goal is to expand the use of this technology for stem cell research to the large community in the life science market. The studies in Phase I will deliver a 1st generation commercial device and consumables that provide a flexible and powerful means to perform unique stem cell assay and sorting experiments at significant cost and time reduction.

描述（由申请人提供）：Cell Microsystems是一家位于北卡罗来纳州的初创生物技术公司，其使命是将一种新颖且价格合理的平台商业化，用于从混合群体中有效分离可行的单细胞或菌落，同时细胞/菌落保持粘附或封装在固体表面上。该公司的“IsoRaft”技术基于北卡罗来纳大学教堂山分校（UNC）最近开发的一种独特的细胞阵列，代表了通过SBIR计划将学术技术转化为市场的理想机会。Cell Microsystems已获得UNC许可，将该技术商业化，用于学术实验室以及生物技术和制药行业的广泛市场。该产品包括用于培养细胞的一次性微阵列（IsoRaft阵列）和用于分离细胞的简单装置