FaceBase Management and Coordination Hub

FaceBase 管理和协调中心

• 批准号: 8463497
• 负责人: JEFFREY C MURRAY
• 金额: $ 162.45万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-21 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8463497
• 关键词: Adopted; Affect; Animal Model; Architecture; Awareness; Behavior; Bioinformatics; Cleaved cell; Clinical; Cognitive; Commit; Communities; Congenital Abnormality; Data; Databases; Defect; Dental; Development; Discipline; Disease; Educational Activities; Educational Materials; Embryology; Face; Family; Fostering; Future; Genome; Genotype; Health; Human; Image; Individual; Internet; Life; Lip structure; Maintenance; Marketing; Modeling; Online Systems; Outcome; Palate; Phenotype; Pilot Projects; Publishing; Repeat Surgery; Research; Research Infrastructure; Research Personnel; Scientist; Security; Site; Source; Speech; Structure; Technology; Time; Translational Research; Update; Work; base; biobank; cancer risk; cleft lip and palate; computer science; craniofacial; data mining; experience; outreach; programs; public health relevance; repository; tool

DESCRIPTION (provided by applicant): Advances in imaging, genome technology, subclinical phenotyping, embryology and other investigative disciplines have provided unique opportunities for developing a better understanding of mid-face development. Clefts that involve the mid-face, in particular those of the lip and the palate are among the most common birth defects and create life-long challenges for affected individuals. These concerns include repeated surgeries, as well as speech, behavior, dental and long-term health issues such as increased risks for cancer and delayed cognitive development. We have assembled a team of committed and experienced craniofacial researchers, plus experts in bioinformatics and computer science, to develop a Face Base Hub that will facilitate research, clinical, and educational activities related to facial development. Our Face Base team consists of collaborators who have worked well together for many years and who bring far-reaching and complementary expertise to the Hub. Our Hub will provide a Face Base web portal, access to extensive databases of both human and animal model data (such as genotypes, sequence data, expression data, facial images and other phenotypes) and a comprehensive set of web-based tools to enhance research opportunities. It will focus on integrating data from diverse sources and models, and to foster translational research in cleft lip and palate. The Hub will provide a forum for connecting investigators, and opportunities to maintain updated information in real-time on research and clinical aspects of cleft lip and palate. It will include educational and biorepository activities that will enhance clinical and public understanding of, and involvement in, facial research. We will build on existing bioinformatic infrastructures that can be adopted for Face Base, utilizing partnerships with such programs as CaBIG, the UCSC genome-browser, and Wikipedia. The outcome will be a significant increase in the ability to rapidly advance craniofacial research, new educational and outreach activities to enhance public and professional awareness of mid-face defects and a future model for broadening these activities across other dental and craniofacial disorders.

描述（由申请人提供）：成像，基因组技术，亚临床表型，胚胎学和其他研究学科的进步为更好地了解中面部发育提供了独特的机会。涉及面中部的裂缝，特别是唇和腭的裂缝是最常见的出生缺陷之一，并为受影响的个体带来终身挑战。这些问题包括重复手术，以及言语，行为，牙齿和长期健康问题，如癌症风险增加和认知发育延迟。我们已经组建了一个由致力于和经验丰富的颅面研究人员，加上生物信息学和计算机科学专家组成的团队，以开发一个Face Base Hub，以促进与面部发育相关的研究，临床和教育活动。我们的Face Base团队由多年来合作良好的合作者组成，他们为中心带来了意义深远的互补专业知识。我们的中心将提供一个Face Base门户网站，访问人类和动物模型数据（如基因型，序列数据，表达数据，面部图像和其他表型）的广泛数据库，以及一套全面的基于网络的工具，以增加研究机会。它将专注于整合来自不同来源和模型的数据，并促进唇腭裂的转化研究。该中心将为研究人员提供一个论坛，并有机会实时更新唇腭裂研究和临床方面的信息。它将包括教育和生物储存活动，这将提高临床和公众对面部研究的理解和参与。我们将利用与CaBIG、UCSC基因组浏览器和维基百科等程序的合作关系，在现有的可用于Face Base的生物信息学基础设施的基础上进行建设。其结果将是快速推进颅面研究的能力显着增加，新的教育和推广活动，以提高公众和专业人士对面中部缺陷的认识，以及在其他牙科和颅面疾病中扩大这些活动的未来模式。