FaceBase Management and Coordination Hub

FaceBase 管理和协调中心

• 批准号: 8063537
• 负责人: JEFFREY C MURRAY
• 金额: $ 175.03万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-21 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8063537
• 关键词: Adopted; Affect; Animal Model; Architecture; Awareness; Behavior; Bioinformatics; Cleaved cell; Clinical; Cognitive; Commit; Communities; Congenital Abnormality; Data; Databases; Defect; Dental; Development; Discipline; Disease; Educational Activities; Educational Materials; Embryology; Face; Family; Fostering; Future; Genome; Genotype; Health; Human; Image; Individual; Internet; Life; Lip structure; Maintenance; Marketing; Modeling; Online Systems; Outcome; Palate; Phenotype; Pilot Projects; Publishing; Repeat Surgery; Research; Research Infrastructure; Research Personnel; Scientist; Security; Site; Source; Speech; Structure; Technology; Time; Translational Research; Update; Work; base; biobank; cancer risk; cleft lip and palate; computer science; craniofacial; data mining; experience; outreach; programs; public health relevance; repository; tool

DESCRIPTION (provided by applicant): Advances in imaging, genome technology, subclinical phenotyping, embryology and other investigative disciplines have provided unique opportunities for developing a better understanding of mid-face development. Clefts that involve the mid-face, in particular those of the lip and the palate are among the most common birth defects and create life-long challenges for affected individuals. These concerns include repeated surgeries, as well as speech, behavior, dental and long-term health issues such as increased risks for cancer and delayed cognitive development. We have assembled a team of committed and experienced craniofacial researchers, plus experts in bioinformatics and computer science, to develop a Face Base Hub that will facilitate research, clinical, and educational activities related to facial development. Our Face Base team consists of collaborators who have worked well together for many years and who bring far-reaching and complementary expertise to the Hub. Our Hub will provide a Face Base web portal, access to extensive databases of both human and animal model data (such as genotypes, sequence data, expression data, facial images and other phenotypes) and a comprehensive set of web-based tools to enhance research opportunities. It will focus on integrating data from diverse sources and models, and to foster translational research in cleft lip and palate. The Hub will provide a forum for connecting investigators, and opportunities to maintain updated information in real-time on research and clinical aspects of cleft lip and palate. It will include educational and biorepository activities that will enhance clinical and public understanding of, and involvement in, facial research. We will build on existing bioinformatic infrastructures that can be adopted for Face Base, utilizing partnerships with such programs as CaBIG, the UCSC genome-browser, and Wikipedia. The outcome will be a significant increase in the ability to rapidly advance craniofacial research, new educational and outreach activities to enhance public and professional awareness of mid-face defects and a future model for broadening these activities across other dental and craniofacial disorders. PUBLIC HEALTH RELEVANCE: The Face Base Hub will provide a common place to bring together the research and clinical communities involved with cleft lip and palate. It will enable scientists to have easily accessible information even before it is published to foster a sense of common purpose in working on these important birth defects. The Hub will also provide clinical updates and educational materials accessible to families and to researchers.

描述(申请人提供)：成像、基因组技术、亚临床表型鉴定、胚胎学和其他研究学科的进步为更好地了解面部中部发育提供了独特的机会。涉及面部中部的唇裂是最常见的出生缺陷之一，对受影响的人来说是终身的挑战。这些担忧包括重复手术，以及言语、行为、牙齿和长期健康问题，如癌症风险增加和认知发育延迟。我们组建了一支专注和经验丰富的颅面研究人员团队，加上生物信息学和计算机科学方面的专家，开发了一个面部基础中心，将促进与面部发育相关的研究、临床和教育活动。我们的Face Base团队由多年合作良好的合作者组成，他们为Hub带来了深远和互补的专业知识。我们的中心将提供一个基于人脸的门户网站，访问人类和动物模型数据(如基因类型、序列数据、表情数据、面部图像和其他表型)的广泛数据库，以及一套全面的基于网络的工具，以增加研究机会。它将专注于整合来自不同来源和模型的数据，并促进唇腭裂的翻译研究。该中心将为联系研究人员提供一个论坛，并提供机会实时维护关于唇腭裂的研究和临床方面的最新信息。它将包括教育和生物库活动，以加强临床和公众对面部研究的了解和参与。我们将利用与CABIG、UCSC基因组浏览器和维基百科等项目的合作伙伴关系，建立可用于Face Base的现有生物信息基础设施。其结果将是迅速推进颅面研究的能力显著提高，开展新的教育和推广活动以提高公众和专业人士对面中部缺陷的认识，并成为未来将这些活动扩大到其他牙科和颅面疾病的模式。 公共卫生相关性：脸部基础中心将提供一个公共场所，将涉及唇腭裂的研究和临床社区聚集在一起。它将使科学家在信息发布之前就能轻松获得这些信息，以培养在研究这些重要的出生缺陷方面的共同使命感。该中心还将向家庭和研究人员提供临床更新和教育材料。