Neurobiological susceptibility to peer influence and drug use in adolescence

青春期对同伴影响和药物使用的神经生物学敏感性

• 批准号: 10413922
• 负责人: Kristen Ann Lindquist
• 金额: $ 67.93万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10413922
• 关键词: Acceleration; Address; Adolescence; Adolescent; Affective; Age; Alcohols; Awareness; Behavior; Biological; Brain; Complex; Data; Development; Drug usage; Environment; Exposure to; Feeling; Friends; Functional Imaging; Funding; Health; Individual; Individual Differences; Intervention; Longevity; Marijuana; Measures; Morbidity - disease rate; Motivation; Neurobiology; Neurosciences; Opioid; Patient Self-Report; Perception; Performance; Predisposition; Prevention; Process; Psychopathology; Punishment; Reporting; Research; Rewards; Risk; Risk Behaviors; Sampling; Social Environment; Social Psychology; Socialization; Substance Addiction; Substance abuse problem; System; Theoretical model; Thinking; Time; Tobacco; United States National Institutes of Health; Variant; Work; adolescent substance use; affective neuroscience; cohort; critical developmental period; early adolescence; executive function; high school; innovation; insight; longitudinal design; maladaptive behavior; mentalization; mortality; neural; neural correlate; neural network; neuroimaging; peer; peer influence; pressure; prospective; protective factors; psychologic; resilience; social; social influence; substance use; successful intervention

Project Summary/Abstract An alarming number of adolescents will engage in substance use (including alcohol, tobacco, marijuana and opioids) before they leave high school, a fact that has serious long-term health and societal impacts. Since most adolescents begin using substances with peers, an understanding of the processes that lead to peer influence susceptibility in the context of substance-using peers offers critical avenues for successful intervention in substance use. Our prior research developed a unique performance-based experimental paradigm for measuring peer influence susceptibility and found that individual differences in susceptibility interact with adolescents’ perceptions of their peers’ substance use to predict their own substance use engagement. However, it remains unclear why some adolescents are more susceptible to peer influence than others, and how development confers increased risk for susceptibility. This work will examine the neural correlates associated with individual differences in peer influence susceptibility. Specifically, we will assess how increased functional connectivity within and between neural networks subserving greater sensitivity to social rewards and punishments, motivation to attain rewards and avoid punishment, and representations of social others is associated with greater peer influence susceptibility. We will also examine a network involved in executive control as a protective factor against later substance use. Using a two-cohort, accelerated longitudinal design including adolescents spanning grades 6-12, we will investigate how individual differences in connectivity within and between candidate neural networks predict prospective substance use initiation in the context of peers. Eight hundred adolescents (age 11-13 years) will complete baseline assessments of substance use, and peer influence susceptibility using an innovative experimental paradigm. A subset (n = 250) of the initial sample will partake in longitudinal task-based functional imaging in year 1 and 3, as well as multi-wave longitudinal assessment occurring at one-year longitudinal intervals in subsequent years 2-5 to obtain extensive data on adolescents’ and peers’ substance use trajectories across a critical developmental period associated with substance use. By delineating the neurobiological markers of social influence susceptibility, project findings can characterize those individuals at greatest risk for substance use, which can inform interventions by targeting the psychological processes that contribute to peer influence susceptibility.

项目概要/摘要 数量惊人的青少年会使用药物（包括酒精、烟草、大麻和 阿片类药物）在他们离开高中之前，这一事实对健康和社会产生了严重的长期影响。自从 大多数青少年开始与同龄人一起使用物质，了解导致同龄人使用物质的过程 在物质使用同龄人的背景下影响敏感性提供了成功的关键途径 干预物质使用。我们之前的研究开发了一种独特的基于性能的实验 测量同伴影响敏感性的范例，发现敏感性的个体差异 与青少年对其同龄人药物使用的看法进行互动，以预测自己的药物使用情况 订婚。然而，目前尚不清楚为什么一些青少年比青少年更容易受到同伴影响。 其他，以及发展如何增加易感性风险。这项工作将检查神经 与同伴影响敏感性的个体差异相关。具体来说，我们将评估 增加神经网络内部和之间的功能连接如何提高对 社会奖励和惩罚、获得奖励和避免惩罚的动机以及 社会他人与更大的同伴影响敏感性相关。我们还将检查涉及的网络 在执行控制中作为防止以后物质使用的保护因素。使用两队列，加速 纵向设计包括跨越6-12年级的青少年，我们将调查个体差异如何 候选神经网络内部和之间的连接性预测未来物质使用的开始 同行的背景。八百名青少年（11-13 岁）将完成以下方面的基线评估： 使用创新的实验范式研究物质使用和同伴影响的敏感性。子集 (n = 250）的初始样本将在第一年和第三年参与纵向基于任务的功能成像，以及 在随后的 2-5 年中以一年纵向间隔进行多波纵向评估 获取有关青少年和同龄人在关键发展阶段的物质使用轨迹的大量数据 与物质使用相关的时期。通过描绘社会影响的神经生物学标记 易感性，项目研究结果可以描述那些最有物质使用风险的人，这可以 通过针对导致同伴影响易感性的心理过程来为干预措施提供信息。

项目成果

From Text to Thought: How Analyzing Language Can Advance Psychological Science.

• DOI: 10.1177/17456916211004899
• 发表时间: 2022-05
• 期刊: PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
• 影响因子: 12.6
• 作者: Jackson, Joshua Conrad;Watts, Joseph;List, Johann-Mattis;Puryear, Curtis;Drabble, Ryan;Lindquist, Kristen A.
• 通讯作者: Lindquist, Kristen A.

Developmental changes in brain function linked with addiction-like social media use two years later.

两年后，大脑功能的发育变化与社交媒体成瘾的使用有关。

• DOI: 10.1093/scan/nsae008
• 发表时间: 2024
• 期刊: Social cognitive and affective neuroscience
• 影响因子: 4.2
• 作者: Flannery,JessicaS;Burnell,Kaitlyn;Kwon,Seh-Joo;Jorgensen,NathanA;Prinstein,MitchellJ;Lindquist,KristenA;Telzer,EvaH
• 通讯作者: Telzer,EvaH

Neural tracking of social hierarchies in adolescents' real-world social networks.

• DOI: 10.1093/scan/nsad064
• 发表时间: 2023-11-17
• 期刊: SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
• 影响因子: 4.2
• 作者: Dai, Junqiang;Jorgensen, Nathan A.;Duell, Natasha;Capella, Jimmy;Maza, Maria T.;Kwon, Seh-Joo;Prinstein, Mitchell J.;Lindquist, Kristen A.;Telzer, Eva H.
• 通讯作者: Telzer, Eva H.

Neural similarity in nucleus accumbens during decision-making for the self and a best friend: Links to adolescents' self-reported susceptibility to peer influence and risk taking.

• DOI: 10.1002/hbm.26317
• 发表时间: 2023-07
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Dai, Junqiang;Kwon, Seh-Joo;Prinstein, Mitchell J.;Telzer, Eva H.;Lindquist, Kristen A.
• 通讯作者: Lindquist, Kristen A.