Metabolite Profiles Preceding Progression to Diabetes Mellitus after Gestational Diabetes
Metabolite Profiles Preceding Progression to Diabetes Mellitus after Gestational Diabetes
批准号:
10398839
负责人:
Erica Pauline Gunderson
金额:
$60.68万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-07-01 至 2025-04-30
关键词:
AddressAdultAgeAsianBiochemical MarkersBiological AssayBiological MarkersBlack raceBloodBlood GlucoseCaringClassificationClinicalCommunitiesConsumptionDefectDeteriorationDiabetes MellitusDiabetes preventionDiseaseEffectivenessElectronic Health RecordEnrollmentErythrocytesEthnic OriginEthnic PopulationEuropean ancestryFastingFunctional disorderFutureGestational DiabetesGlucoseGlycosylated HemoglobinGlycosylated hemoglobin AGoalsHealthcare SystemsHexosesHispanicHospitalsHyperglycemiaImpairmentInfantInsulinInsulin ResistanceIntegrated Health Care SystemsInterventionLaboratoriesLinkLipidsMeasuresMedicalMetabolicMethodologyMinorityMothersNatural HistoryNon-Insulin-Dependent Diabetes MellitusOGTTPathway interactionsPatient Self-ReportPersonsPhenotypePlasmaPopulationPositioning AttributePostpartum PeriodPrediabetes syndromePredictive ValuePregnancyPregnancy ComplicationsProspective cohortRaceRecommendationResearchRiskRisk FactorsSamplingTestingTimeVisitWomanbiobankclinical careclinical riskcohortdiabetes riskethnic diversityfasting glucosefeedingfollow-upglucose tolerancehigh riskhigh risk populationimpaired glucose toleranceimprovedinsightinsulin secretionmembermetabolic phenotypemetabolic profilemetabolomicsmulti-racialnew therapeutic targetnovel strategiespersonalized interventionpoint of careprecision medicinepredictive markerpredictive modelingpredictive toolspreventprospectiveracial diversityracial populationreceptorreproductiveresponserisk predictionrisk stratificationtooluptakeyoung woman
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
Metabolomics has emerged as a novel approach to identify alterations in metabolites to improve prediction
of type 2 diabetes mellitus (DM) beyond blood glucose. Women with gestational diabetes mellitus (GDM) have
an extremely high rate of conversion to diabetes within 5 to 10 years post-delivery. However, models for
prediction of DM using clinical or metabolic measures are unavailable for this high-risk group. Oral glucose
tolerance testing (OGTT) is recommended at 4 to 12 weeks postpartum, but the OGTT is burdensome for new
mothers and uptake is low. The Study of Women Infant Feeding, and Type 2 Diabetes After GDM (SWIFT)
R01HD050625 (Gunderson PI) enrolled 1,035 women with GDM in 2008 to 2011 and administered 2-hr
75 g research OGTTs and comprehensive assessments from 6-9 weeks postpartum (baseline) and
annually through two years post-delivery. This prospective, well-characterized GDM cohort is uniquely
positioned to address major gaps in our understanding of the pathophysiology and timing of transitions to DM
following GDM pregnancy. Our research team conducted the first study to use a targeted metabolomics
approach to identify and validate a metabolite profile predictive of DM among women with GDM. This study
measured 182 metabolites previously linked with incident DM in adults to identify a metabolite profile consisting
of 4 analyte isotypes [BCAAs, hexoses, PCaeC40:5, SM(OH)C14:1] with predictive ability (83%) that exceeded
fasting glucose alone or 2-hr post-load glucose (72-73%). Although promising, we propose to refine this profile
in the entire cohort, greatly expand the lipid metabolites and test its predictive ability with longer-term follow up.
The overall study goal is to identify a metabolite profile from early postpartum plasma samples that
is highly predictive of incident DM up to 8 years post-delivery in women with GDM. The SWIFT cohort is
exceptional for its racial/ethnic diversity (75% minority), large size, longitudinal Biobank from multiple
research OGTTs and detailed assessments from early through 2 years postpartum with high retention
(83%), and ongoing surveillance via electronic health records (EHR) within a stable membership (84%
remain members 5 years later). The timing is optimal for a 4th in-person research visit at ~8th year post-
baseline to re-assess glucose tolerance and develop prediction tools. The specific aims are: Aim 1. To
identify and refine metabolite profiles at 6-9 weeks postpartum (baseline) that better predict incident diabetes
following GDM pregnancy; we hypothesize that metabolite profiles identified at 6-9 weeks postpartum will be
highly predictive of DM during early (2-year) and later (8-year) follow up periods; Aim 2. To characterize the
metabolic profiles at consecutive time points across follow up (baseline, 1 to 2 years, and 8 years) and
evaluate their relationship to transitions in glucose tolerance; we hypothesize that distinct metabolite profiles
will be strongly related to the stability or deterioration in glucose tolerance over time. An exploratory aim is to
develop distinct metabolite profiles highly predictive of incident DM within specific race/ethnicity groups.
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Prolactin and Maternal Metabolism in Women With a Recent GDM Pregnancy and Links to Future T2D: The SWIFT Study.
最近怀孕的 GDM 女性的催乳素和母体代谢以及与未来 T2D 的联系:SWIFT 研究。
DOI:
10.1210/clinem/dgac346
发表时间:
2022
期刊:
The Journal of clinical endocrinology and metabolism
影响因子:
--
作者:
[Zhang,Ziyi, Piro,AnthonyL, Allalou,Amina, Alexeeff,StaceyE, Dai,FeihanF, Gunderson,EricaP, Wheeler,MichaelB]
通讯作者:
Wheeler,MichaelB
DOI:
10.1016/j.isci.2020.101566
发表时间:
2020-10-23
期刊:
iScience
影响因子:
5.8
作者:
[Khan SR, Manialawy Y, Obersterescu A, Cox BJ, Gunderson EP, Wheeler MB]
通讯作者:
Wheeler MB
DOI:
10.1186/s12916-021-02095-1
发表时间:
2021-10-08
期刊:
BMC medicine
影响因子:
9.3
作者:
[Zhang Z, Lai M, Piro AL, Alexeeff SE, Allalou A, Röst HL, Dai FF, Wheeler MB, Gunderson EP]
通讯作者:
Gunderson EP
DOI:
10.1007/s00125-020-05379-y
发表时间:
2021-05
期刊:
Diabetologia
影响因子:
8.2
作者:
[Vandyousefi S, Davis JN, Gunderson EP]
通讯作者:
Gunderson EP
Biomarker of Pancreatic B-cell Loss Predicting Progression to Type 2 Diabetes After Gestational Diabetes
-
批准号:10583645
-
项目类别:
-
资助金额:$68.01万
-
财政年份:2023
-
负责人:Erica Pauline Gunderson
-
依托单位:
Fetal and Early Postnatal Influences on Child Metabolic Health After Gestational Diabetes
-
批准号:10159898
-
项目类别:
-
资助金额:$67.31万
-
财政年份:2020
-
负责人:Erica Pauline Gunderson
-
依托单位:
Fetal and Early Postnatal Influences on Child Metabolic Health After Gestational Diabetes
-
批准号:10399625
-
项目类别:
-
资助金额:$68.2万
-
财政年份:2020
-
负责人:Erica Pauline Gunderson
-
依托单位:
Fetal and Early Postnatal Influences on Child Metabolic Health After Gestational Diabetes
-
批准号:10616503
-
项目类别:
-
资助金额:$71.9万
-
财政年份:2020
-
负责人:Erica Pauline Gunderson
-
依托单位:
Prenatal Blood Pressure Patterns to Predict Pregnancy-Related Hypertension and Later Life Cardiovascular Risk
-
批准号:10263402
-
项目类别:
-
资助金额:$24.32万
-
财政年份:2018
-
负责人:Erica Pauline Gunderson
-
依托单位:
Prenatal Blood Pressure Patterns to Predict Pregnancy-Related Hypertension and Later Life Cardiovascular Risk
-
批准号:10065013
-
项目类别:
-
资助金额:$75.39万
-
财政年份:2018
-
负责人:Erica Pauline Gunderson
-
依托单位:
Prenatal Blood Pressure Patterns to Predict Pregnancy-Related Hypertension and Later Life Cardiovascular Risk
-
批准号:10318984
-
项目类别:
-
资助金额:$73.7万
-
财政年份:2018
-
负责人:Erica Pauline Gunderson
-
依托单位:
Metabolite Profiles Preceding Progression to Diabetes Mellitus after Gestational Diabetes
-
批准号:9920010
-
项目类别:
-
资助金额:$62.09万
-
财政年份:2018
-
负责人:Erica Pauline Gunderson
-
依托单位:
Pregnancy-Related Risk Factors and Glucose Intolerance in Women during Midlife
-
批准号:8943543
-
项目类别:
-
资助金额:$68.04万
-
财政年份:2015
-
负责人:Erica Pauline Gunderson
-
依托单位:
Infant Temperament and Early Infant Growth and Child Overweight in GDM Offspring
-
批准号:8766265
-
项目类别:
-
资助金额:$19.5万
-
财政年份:2014
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Incidence of Diabetes Mellitus in CARDIA Women
-
批准号:8731534
-
项目类别:
-
资助金额:$9.98万
-
财政年份:2011
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Incidence of Diabetes Mellitus in CARDIA Women
-
批准号:8186442
-
项目类别:
-
资助金额:$73.6万
-
财政年份:2011
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Incidence of Diabetes Mellitus in CARDIA Women
-
批准号:8692753
-
项目类别:
-
资助金额:$62.39万
-
财政年份:2011
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Incidence of Diabetes Mellitus in CARDIA Women
-
批准号:8299626
-
项目类别:
-
资助金额:$65.0万
-
财政年份:2011
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Incidence of Diabetes Mellitus in CARDIA Women
-
批准号:8484399
-
项目类别:
-
资助金额:$62.41万
-
财政年份:2011
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Glucose Tolerance After GDM Pregnancy
-
批准号:7928671
-
项目类别:
-
资助金额:$9.28万
-
财政年份:2009
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Glucose Tolerance After GDM Pregnancy
-
批准号:7418574
-
项目类别:
-
资助金额:$54.8万
-
财政年份:2007
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Glucose Tolerance After GDM Pregnancy
-
批准号:8204090
-
项目类别:
-
资助金额:$15.4万
-
财政年份:2007
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Glucose Tolerance After GDM Pregnancy
-
批准号:7584106
-
项目类别:
-
资助金额:$54.85万
-
财政年份:2007
-
负责人:Erica Pauline Gunderson
-
依托单位:
Lactation and Glucose Tolerance After GDM Pregnancy
-
批准号:7770834
-
项目类别:
-
资助金额:$54.37万
-
财政年份:2007
-
负责人:Erica Pauline Gunderson
-
依托单位:
海外基金