Harvard Chan School NIEHS Center for Environmental Health

快速的技术发展和日益增长的网络和连接世界扩大了我们的 能够测量外部环境、人类生物学及其相互作用，产生丰富和 人和地方环境暴露的细微差别图片。环境健康的未来将是 一种跨越各种和丰富的曝光空间的复杂整合。考虑到这一点，这次会议的主题是 哈佛大学陈学堂-NIEHS中心是对曝光环境和综合效果的重新设想 对人和场所的化学和非化学应激源进行分析，以更好地了解接触对 人类健康。我们的主题将建立在哈佛大学陈氏学派-NIEHS的独特和决定性力量的基础上 环境健康中心；我们无与伦比的环境人口和患者研究组合 暴露及其对健康的影响。这些关于人类受试者暴露在现实世界环境中的研究 确保中心的研究可以随时转化为公共卫生政策和临床实践。这些 以人口为基础的调查与机械的实验室研究相结合，以阐明复杂的， 现实生活环境会影响健康。该中心将继续促进 研究种群和生物机制，并将专门开发和应用现有的最佳 检查生活环境中暴露的复杂性的技术和方法。我们的社区 参与核心(CEC)支持中心重新设想环境的目标，作为 当地社区帮助研究人员更好地想象现实世界中生活的环境暴露空间， 并将中心的研究转化为公共政策和临床实践，造福社区。 为了促进互动，该中心围绕三个研究核心组织，代表主要 跨领域的环境健康暴露：颗粒物和其他空气污染物、金属和有机 化学制品。每个研究核心都有工作效率、持续增长潜力和 整合和催化未来领导力的能力。每个研究核心都是多学科的， 部署了我们全方位的智力资源，并具有毒理学、基本机制、体外模型、 动物模型、基因-环境相互作用、流行病学、风险分析和风险沟通。这个 研究核心得到了综合健康科学设施核心的支持，该核心提供了获取 边缘实验室和暴露科学资源；环境统计和生物信息学核心 提供尖端的统计资源，包括开发分析复杂类型的方法 在我们关注的综合曝光和结果空间中发现的混合物；以及新的 地理和背景测量核心，将提供指导和工具来概念化和 衡量广阔的环境景观。CEC为研究提供了一个社区环境，并 在该中心内开展综合科学，并与我们的研究和设施核心密切接触。

Rapid technological developments and the increasingly wired and connected world have expanded our ability to measure the external environment, human biology, and their interaction to generate a rich and nuanced picture of environmental exposures of people and place. The future of environmental health will be one of complex integration across a varied and rich exposure space. With this in mind, the theme of the Harvard Chan School-NIEHS Center is a re-envisioning of the exposure environment and the integrated effects of chemical and non-chemical stressors of people and place to better understand the impact of exposure on human health. Our theme will build on a unique and defining strength of the Harvard Chan School-NIEHS Center for Environmental Health; our unmatched portfolio of population and patient studies of environmental exposures and their health effects. These studies of the real-world environmental exposures of human subjects ensure that Center research can readily translate into public health policy and clinical practice. These population-based investigations combine with mechanistic laboratory studies to illuminate how the complex, real world lived environment acts to affect health. The Center will continue to foster integration across population and biological mechanism studies, and will also specifically develop and apply the best available technologies and methods to examine the complexity of exposures in the lived environment. Our Community Engagement Core (CEC) supports the Center’s goal to re-envision the environment, serving as a conduit for the local community to help researchers better envision the real world lived environmental exposure space, and to translate Center research into public policy and clinical practice efforts to benefit the community. To facilitate interaction, the Center is organized around three Research Cores representing major cross-cutting environmental health exposures: Particulate Matter and Other Air Pollutants, Metals, and Organic chemicals. Each of the Research Cores has a track record of productivity, potential for continued growth, and the ability to integrate and catalyze leadership in the future. Each Research Core is multidisciplinary and deploys the full range of our intellectual resources and features toxicology, basic mechanisms, in vitro models, animal models, gene-environment interactions, epidemiology, risk analysis, and risk communication. The Research Cores are supported by the Integrated Health Sciences Facility Core that provides access to cutting edge laboratory and exposure science resources; the Environmental Statistics and Bioinformatics Core that provides cutting edge statistical resources including development of methods to analyze the kind of complex mixtures that are found in the integrated exposure and outcome space we are focusing on; and the new Geographical and Contextual Measures Core that will provide both guidance and tools to conceptualize and measure the broad environmental landscape. The CEC provides a community context for the research and integrated sciences occurring within the Center and engages closely with our research and facility cores.