Molecular Imaging Chemistry

分子成像化学

基本信息

  • 批准号:
    8195500
  • 负责人:
  • 金额:
    $ 7.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-01-01 至 2016-12-31
  • 项目状态:
    已结题

项目摘要

The MICC will continue to serve as a crucial interface for various proposed interdisciplinary projects. Dr. Vijay Sharma is the MICC Director. He is a chemist trained in inorganic and organic chemistry with extensive experience in radiopharmaceutical and conjugation chemistry and will be directly responsible for managing, prioritizing, and executing the various day-to-day activities ofthe MICC. Sam Achilefu, Ph.D., ICMIC preceptor provides additional peptide synthesis and fluorophore chemistry expertise for the MICC. The new MICC will be moving and expand with the BRIGHT Institute onto approximately 1,200 sq. ft. of of space now under construction (Jan. 2011 completion) on the 7* floor of the new BJC Institute of Health building, an 11 story state-of-the-art stmcture in the center of the Washington University Medical School campus (See Appendix 1). In addition, PET chemistry laboratories in the Clinical Sciences Research Building and South Building (Robert Mach, Ph.D.) serve as supplemental resources and radiochemistry laboratories for the ICMIC, thereby enabling full access to high level synthetic chemistry facilities. The DBBS Chemical Biology Labs located down the street from the BJC Institute of Health building house a 300 MHz NMR spectrometer and X-ray diffractometer. Additionally, a new 400 MHz NMR spectrophotometer has been purchased through a shared Instrumentation grant and will be installed in the Biochemistry Department down the street. The Washington University Danforth Campus, Department of Chemistry Spectroscopy Laboratory houses IR, mass spect, and NMR spectrometers available for use by the Core. We have full access to these later instruments for discounted fees. The MICC instruments include a hot cell for PET radiochemistry, Rotovap x 3, vacuum pumps, fume hoods x 8, stills x 4, hot plates, ovens, analytical scales, TLC scanning radiometric detector, computer-controlled gradient HPLC systems x 6 (Waters x 5, Rainin), fraction collector, Fluorometer (Varian), FT-IR (PerkinElmer), UV/Vis spectrophotometer (PerkinElmer), GC-MS spectrophotometer (Varian), chemical synthesis microwave (CEM), sealed glove box, solvents, lead fort and storage. Peptide synthesis can be performed for the MICC under the direction of Dr. Achilefu. Synthetic activities of the several radiochemistry labs on campus are coordinated depending on the needs of ICMIC investigators and project logistics. Several radiopharmaceuticals necessary for execution of ICMIC Projects, such as ^^FHBG (Research Project 4), are synthesized in the MICC for pre-clinical studies and will be synthesized by the Clinical PET Radiopharmacy under an IND for clinical studies. The MICC consists of three functional components: A) chemistry sen/ices for other investigators; B) discovery research and validation of new agents, and C) training of students, post-doctoral fellows, technical staff, and investigators in the development of specialized compounds and reagents for molecular imaging applications.
中集信息中心将继续作为各种拟议的跨学科项目的关键接口。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Vijay Sharma其他文献

Vijay Sharma的其他文献

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{{ truncateString('Vijay Sharma', 18)}}的其他基金

PET Tracers for Imaging ROS Activity
用于 ROS 活动成像的 PET 示踪剂
  • 批准号:
    10715916
  • 财政年份:
    2018
  • 资助金额:
    $ 7.97万
  • 项目类别:
Imaging iNOS and ROS/RNS
iNOS 和 ROS/RNS 成像
  • 批准号:
    10254234
  • 财政年份:
    2018
  • 资助金额:
    $ 7.97万
  • 项目类别:
Imaging iNOS and ROS/RNS
iNOS 和 ROS/RNS 成像
  • 批准号:
    10480880
  • 财政年份:
    2018
  • 资助金额:
    $ 7.97万
  • 项目类别:
NOVEL PET TRACERS FOR IMAGING OF ALZHEIMER'S DISEASE
用于阿尔茨海默病成像的新型宠物示踪剂
  • 批准号:
    8882624
  • 财政年份:
    2015
  • 资助金额:
    $ 7.97万
  • 项目类别:
NOVEL PET TRACERS FOR IMAGING OF ALZHEIMER'S DISEASE
用于阿尔茨海默病成像的新型宠物示踪剂
  • 批准号:
    9058975
  • 财政年份:
    2015
  • 资助金额:
    $ 7.97万
  • 项目类别:
NOVEL PET TRACERS FOR IMAGING OF ALZHEIMER'S DISEASE
用于阿尔茨海默病成像的新型宠物示踪剂
  • 批准号:
    9223626
  • 财政年份:
    2015
  • 资助金额:
    $ 7.97万
  • 项目类别:
NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
用于心肌灌注成像的新型宠物试剂
  • 批准号:
    8883682
  • 财政年份:
    2012
  • 资助金额:
    $ 7.97万
  • 项目类别:
NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
用于心肌灌注成像的新型宠物试剂
  • 批准号:
    8371710
  • 财政年份:
    2012
  • 资助金额:
    $ 7.97万
  • 项目类别:
NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
用于心肌灌注成像的新型宠物试剂
  • 批准号:
    8511806
  • 财政年份:
    2012
  • 资助金额:
    $ 7.97万
  • 项目类别:
TARGETING CHLOROQUINE RESISTANCE W/ METAL(III) METALLOPHARMACEUTICALS
使用金属 (III) 金属药物靶向氯喹耐药性
  • 批准号:
    8361327
  • 财政年份:
    2011
  • 资助金额:
    $ 7.97万
  • 项目类别:

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