Molecular Imaging Chemistry

分子成像化学

• 批准号: 8195500
• 负责人: Vijay Sharma
• 金额: $ 7.97万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195500
• 关键词: Biochemistry; Biology; Boxing; Cells; Chemicals; Chemistry; Clinical; Clinical Research; Clinical Sciences; Computers; Development; Doctor of Philosophy; Fees; Floor; Grant; Health; High Pressure Liquid Chromatography; Housing; Ice; Inorganic Chemistry; Institutes; Laboratories; Lead; Logistics; New Agents; Organic Chemistry; Peptide Synthesis; Positron-Emission Tomography; Postdoctoral Fellow; Radiochemistry; Radiopharmaceuticals; Reagent; Research; Research Personnel; Research Project Grants; Resources; Roentgen Rays; Scanning; Solvents; Spectrum Analysis; Students; Synthesis Chemistry; System; Training; Universities; Vacuum Pumps; Validation; Washington; Water; chemical synthesis; detector; discount; experience; fluorophore; in vivo Cellular and Molecular Imaging Centers; instrument; instrumentation; medical schools; microwave electromagnetic radiation; molecular imaging; preclinical study; seal

The MICC will continue to serve as a crucial interface for various proposed interdisciplinary projects. Dr. Vijay Sharma is the MICC Director. He is a chemist trained in inorganic and organic chemistry with extensive experience in radiopharmaceutical and conjugation chemistry and will be directly responsible for managing, prioritizing, and executing the various day-to-day activities ofthe MICC. Sam Achilefu, Ph.D., ICMIC preceptor provides additional peptide synthesis and fluorophore chemistry expertise for the MICC. The new MICC will be moving and expand with the BRIGHT Institute onto approximately 1,200 sq. ft. of of space now under construction (Jan. 2011 completion) on the 7* floor of the new BJC Institute of Health building, an 11 story state-of-the-art stmcture in the center of the Washington University Medical School campus (See Appendix 1). In addition, PET chemistry laboratories in the Clinical Sciences Research Building and South Building (Robert Mach, Ph.D.) serve as supplemental resources and radiochemistry laboratories for the ICMIC, thereby enabling full access to high level synthetic chemistry facilities. The DBBS Chemical Biology Labs located down the street from the BJC Institute of Health building house a 300 MHz NMR spectrometer and X-ray diffractometer. Additionally, a new 400 MHz NMR spectrophotometer has been purchased through a shared Instrumentation grant and will be installed in the Biochemistry Department down the street. The Washington University Danforth Campus, Department of Chemistry Spectroscopy Laboratory houses IR, mass spect, and NMR spectrometers available for use by the Core. We have full access to these later instruments for discounted fees. The MICC instruments include a hot cell for PET radiochemistry, Rotovap x 3, vacuum pumps, fume hoods x 8, stills x 4, hot plates, ovens, analytical scales, TLC scanning radiometric detector, computer-controlled gradient HPLC systems x 6 (Waters x 5, Rainin), fraction collector, Fluorometer (Varian), FT-IR (PerkinElmer), UV/Vis spectrophotometer (PerkinElmer), GC-MS spectrophotometer (Varian), chemical synthesis microwave (CEM), sealed glove box, solvents, lead fort and storage. Peptide synthesis can be performed for the MICC under the direction of Dr. Achilefu. Synthetic activities of the several radiochemistry labs on campus are coordinated depending on the needs of ICMIC investigators and project logistics. Several radiopharmaceuticals necessary for execution of ICMIC Projects, such as ^^FHBG (Research Project 4), are synthesized in the MICC for pre-clinical studies and will be synthesized by the Clinical PET Radiopharmacy under an IND for clinical studies. The MICC consists of three functional components: A) chemistry sen/ices for other investigators; B) discovery research and validation of new agents, and C) training of students, post-doctoral fellows, technical staff, and investigators in the development of specialized compounds and reagents for molecular imaging applications.

MICC将继续作为各种拟议的跨学科项目的重要接口。 Vijay Sharma博士是MICC主任。他是一名受过无机化学和有机化学培训的化学家 在放射性药物和偶联化学方面有丰富的经验，并将直接负责 管理、排定和执行MICC的各种日常活动。萨姆·阿奇勒夫，ICMIC博士 Proeptor为MICC提供更多的多肽合成和荧光团化学专业知识。 新的MICC将与BLAT研究所一起搬迁和扩大，面积约为1200平方米。英国《金融时报》的 新的北京卫生研究院7层楼的在建空间(2011年1月竣工) 位于华盛顿大学医学院中心的11层最先进的建筑 校园(见附录1)。此外，临床科学研究大楼内的PET化学实验室 和南楼(Robert Mach，Ph.D.)作为补充资源和放射化学实验室 对于ICMIC，从而使人们能够充分利用高水平的合成化学设施。DBBS化学公司 生物实验室位于北京卫生研究院大楼附近的街道上，配备了300 MHz核磁共振 光谱仪和X射线衍射仪。此外，一个新的400 MHz核磁共振分光光度计已经被 通过共享仪器拨款购买，并将安装在生物化学系 在街上。华盛顿大学丹福斯校区化学光谱实验室 配备了可供Core使用的IR、质谱仪和核磁共振光谱仪。我们完全有权访问这些 后期票据收取折扣费。MICC仪器包括一个用于PET放射化学的热室， Rotovap x 3，真空泵，通风柜x 8，蒸馏器x 4，热板，烤箱，分析秤，TLC扫描 辐射探测器，计算机控制的梯度高效液相系统x 6(Waters x 5，Rainin)，组分收集器， 荧光仪(VARIAN)、FT-IR(PerkinElmer)、UV/Vis分光光度计(PerkinElmer)、GC-MS 分光光度计(瓦里安)、化学合成微波(CEM)、密封手套箱、溶剂、铅堡和 储藏室。在阿奇勒夫博士的指导下，可以为MICC进行多肽合成。合成的 校园内几个放射化学实验室的活动根据ICMIC的需要进行协调 调查人员和项目后勤。执行ICMIC项目所需的几种放射性药物， 例如^FHBG(研究项目4)，在MICC中合成用于临床前研究，并将被 由IND下的临床PET放射性药物研究所合成，用于临床研究。 MICC由三个功能部分组成：A)为其他研究人员提供化学服务；B) 新代理人的发现、研究和验证，以及C)培训学生、博士后研究员、技术人员 开发分子成像专用化合物和试剂的工作人员和研究人员 申请。