Imaging iNOS and ROS/RNS
iNOS 和 ROS/RNS 成像
基本信息
- 批准号:10254234
- 负责人:
- 金额:$ 24.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffinityAnimal Disease ModelsAnimal ModelAntioxidantsAtherosclerosisBiochemical PathwayBiodistributionBiological MarkersBloodCancer ModelCardiacCell SurvivalCell physiologyCellsCharacteristicsChronicCollaborationsDataDiseaseDisease modelDrug KineticsEnzymesFamilyFluoxetineFree RadicalsFunctional disorderGalliumGlycineGoalsHumanImageImaging DeviceImaging TechniquesImpairmentIn VitroInflammationInflammatoryInstitutionLaboratoriesLeadLigandsLuminolLung diseasesMalignant NeoplasmsMeasuresMediatingMediator of activation proteinMethodologyMissionMolecularMolecular TargetMonitorMovement DisordersNOS2A geneNeurodegenerative DisordersNitric OxideNitric Oxide SynthaseOxidative StressPathogenesisPenetrationPeroxonitritePharmacologyPhasePositron-Emission TomographyPre-Clinical ModelProcessProductionPrognostic MarkerRadiolabeledRadiometryRadiopharmaceuticalsReactive Nitrogen SpeciesReactive Oxygen SpeciesResearchResourcesRoleSensitivity and SpecificitySuperoxidesTechnologyTexas redTherapeuticTimeTissuesTracerTranslationsValidationanalogbasebioluminescence imagingcytokinedesignin vivoinhibitor/antagonistinsightlead optimizationmacrophagemolecular imagingmonocytemouse modelneutrophilnon-invasive imagingnovelpre-clinicalradiotracerresponsetherapeutic target
项目摘要
TR&D 3 Project Summary
The primary goal of TR&D 3 is to develop PET radiopharmaceuticals to enable molecular imaging of interplay
between inflammation and oxidative stress. Of note,
oxidative stress represents an imbalance between
production of reactive oxygen species (ROS) and their elimination or mitigation by antioxidants. Excess ROS is
in the pathogenesis of a wide range of diseases. Importantly, a key mediator of oxidative stress is nitric
oxide (NO) which is generated by the nitric oxide synthase (NOS) family of enzymes. Among this NOS family,
the inducible form of NO has been implicated in a variety of diseases, wherein either acute or chronic
inflammation is central to disease pathogenesis. Moreover, excess NO can react with free radicals to generate
reactive nitrogen species (RNS) such as peroxynitrites, thus impairing cell function. In view of the high
significance of abovementioned molecular targets in the pathogenesis of disease, the specific aims of TR&D 3
are to design, synthesize, and validate: 1) radiotracers targeting inducible nitric oxide synthase (iNOS); and 2)
gallium-68 incorporated PET tracers for imaging ROS/RNS-mediated oxidative stress. Radiotracers developed
in TR&D 3 will be initially validated in animal models at our institution. Following validations of target-sensitivity
and –specificity of new PET tracers at a molecular level in vivo using proposed methodologies, TR&D 3 will
collaborate with CPs to validate and further optimize the technology for wide utility in disease-specific
applications. Overall, these PET tracers will provide novel imaging resource to interrogate role of these vital
biomarkers in inflammation.
involved
TR&D 3项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vijay Sharma其他文献
Vijay Sharma的其他文献
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{{ truncateString('Vijay Sharma', 18)}}的其他基金
NOVEL PET TRACERS FOR IMAGING OF ALZHEIMER'S DISEASE
用于阿尔茨海默病成像的新型宠物示踪剂
- 批准号:
8882624 - 财政年份:2015
- 资助金额:
$ 24.14万 - 项目类别:
NOVEL PET TRACERS FOR IMAGING OF ALZHEIMER'S DISEASE
用于阿尔茨海默病成像的新型宠物示踪剂
- 批准号:
9058975 - 财政年份:2015
- 资助金额:
$ 24.14万 - 项目类别:
NOVEL PET TRACERS FOR IMAGING OF ALZHEIMER'S DISEASE
用于阿尔茨海默病成像的新型宠物示踪剂
- 批准号:
9223626 - 财政年份:2015
- 资助金额:
$ 24.14万 - 项目类别:
NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
用于心肌灌注成像的新型宠物试剂
- 批准号:
8883682 - 财政年份:2012
- 资助金额:
$ 24.14万 - 项目类别:
NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
用于心肌灌注成像的新型宠物试剂
- 批准号:
8371710 - 财政年份:2012
- 资助金额:
$ 24.14万 - 项目类别:
NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
用于心肌灌注成像的新型宠物试剂
- 批准号:
8511806 - 财政年份:2012
- 资助金额:
$ 24.14万 - 项目类别:
TARGETING CHLOROQUINE RESISTANCE W/ METAL(III) METALLOPHARMACEUTICALS
使用金属 (III) 金属药物靶向氯喹耐药性
- 批准号:
8361327 - 财政年份:2011
- 资助金额:
$ 24.14万 - 项目类别:
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