AIDS and Cancer Specimen Resource Central Office and Data Coordinating Center

描述(由申请人提供)：本提案是关于继续设立艾滋病和癌症标本资源中心(CODCC)的申请，目的是协调和管理艾滋病和癌症标本资源的活动。ACSR是一个最初由美国国家癌症研究所(NCI)于1994年资助的项目，它代表了ACSR继续资助的整体续签申请的子集。自该计划启动以来，已有三家参与机构成功地维持了一项全国性的ACSR计划。在过去的六年中，ACSR的国家业务职能一直通过加州大学旧金山分校进行。 CODCC的具体目标： 1.治理：与ACSR指导委员会和NCI合作，提供领导和管理，以支持ACSR和区域生物质库(RBR)的主要目的和使命声明。这一目标包括：行政管理和协调所有地区生物库运营办公室的工作；确保全ACSR理解和遵守指导委员会的指导方针，包括人类研究办公室的人类研究保护规定、NCI最佳实践、HIPAA等；带头制定和实施一致和有文件记录的内部指南和检查，如操作手册、标准操作程序、审计程序和质量控制程序；组织指导委员会会议和其他ACSR范围的会议和会议；准备和分发议程和纪要；跟踪指导委员会的决定；维护ACSR的中央文件。 2.协调：作为协调机构，制定、维护和跟踪ACSR范围内的所有计划和服务。这一目标包括：协调向研究人员分发标本，包括跟踪研究人员使用ACSR材料产生的出版物、赠款、专利、摘要等；创建和维护ACSR的生物信息学基础设施，包括全面的标本和临床数据库以及可搜索的网络界面；促进标本采购方面的合作努力，以满足国内外艾滋病毒相关恶性肿瘤研究人员的需求；以及协调开发新的ACSR产品(如TMA和DNA文库)，以满足随着流行病和技术进步的研究人员的特殊需求。 3.外展：通过向研究和患者社区积极的外展和广告计划，扩大ACSR的利用率和相关性。这一目标包括：与指导委员会合作，制定并持续改进ACSR的整体推广计划；开发和维护推广材料，包括时事通讯、ACSR网站和电子邮件列表、在科学会议和会议上使用的摊位以及信息CD；参加相关的科学会议和会议，使研究人员了解ACSR的服务和产品；以及开发和带头ACSR的计划，教育患者社区了解ACSR的存在和价值。

DESCRIPTION (provided by applicant): This proposal represents an application for the continuation of the ACSR Central Operations and Data Coordinating Center (CODCC) to provide the coordination and management of activities of the AIDS and Cancer Specimen Resource (ACSR). The ACSR is a program initially funded by the National Cancer Institute (NCI) in 1994 and represents a subset of an overall renewal application for continued funding of the ACSR. Since the initiation of this program, three participating institutions have successfully maintained a national ACSR program. During the past six years, the national operational function of the ACSR has been conducted through the University of California, San Francisco. Specific Aims of the CODCC: 1. Governance: Work with the ACSR Steering Committee and NCI to provide leadership and management to support the primary purpose and mission statement of the ACSR and the Regional Biospecimen Repositories (RBRs). This aim includes: Administrative management and coordination of the workings of all Regional Biorepository Operations Offices; Ensuring ACSR-wide understanding of and adherence to guidelines including Office of Human Research of Human Research Protection regulations, NCI Best Practices, HIPAA, etc.; Spearheading the development and performance of consistent and well-documented internal guidelines and checks, such as the Manual of Operations, Standard Operating Procedures, audit procedures, and quality control program; and Organizing Steering Committee meetings and other ACSR-wide meetings and conferences; preparing and distributing agendas and minutes; following up on Steering Committee decisions; maintaining central files for the ACSR. 2. Coordination: Serve as the coordinating body to develop, maintain, and track all ACSR-wide programs and services. This aim includes: Coordinating distribution of specimens to researchers, including the tracking of publications, grants, patents, abstracts, etc. that result from researchers' use of ACSR materials; Creating and maintaining ACSR's bioinformatics infrastructure, including a comprehensive specimen and clinical database and searchable web interface; Facilitating collaborative endeavors for specimen procurement to meet the needs of researchers in HIV-related malignancies in both the domestic and international arenas; and Coordinating the development of new ACSR products (such as TMAs and a DNA library) to meet the specific needs of researchers as the epidemic and technology advances. 3. Outreach: Expand the utilization and relevance of the ACSR through an active outreach and advertising program to both the research and patient community. This aim includes: Working with the Steering Committee to develop and continually improve the overall ACSR outreach program; Developing and maintaining outreach materials, including a newsletter, the ACSR website and email list, a booth for use at scientific meetings and conferences, and an informational CD; Attending relevant scientific meetings and conferences, to make researchers aware of ACSR services and products; and Developing and spearheading the ACSR's program to educate the patient community about the existence and value of the ACSR.