AIDS and Cancer Specimen Resource (ACSR)

艾滋病和癌症样本资源 (ACSR)

• 批准号: 9346027
• 负责人: MICHAEL Shannon MCGRATH
• 金额: $ 411.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9346027
• 关键词: AIDS/HIV problem; Acceleration; Acquired Immunodeficiency Syndrome; Address; Anogenital cancer; Arizona; Basic Science; Behavioral; Biological; Biological Preservation; Cause of Death; Clinical; Clinical Data; Clinical Research; Collection; Communities; Complement; Consultations; DNA Library; Data Coordinating Center; Developing Countries; Development; Diagnosis; Ensure; Epidemic; Equipment and supply inventories; Foundations; Funding; Future; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; Image; Incidence; Individual; Industry; Institutes; Institution; Instruction; Interdisciplinary Study; International; Kaposi Sarcoma; Laboratories; Leadership; Liquid substance; Maintenance; Malignant Neoplasms; Malignant neoplasm of lung; Medicine; Methods; Mission; National Cancer Institute; Non-Hodgkin' s Lymphoma; Pathogenesis; Patients; Population; Positioning Attribute; Procedures; Process; Program Evaluation; Research; Research Infrastructure; Research Personnel; Resources; Role; Sampling; Scientist; Services; Silver; Slide; Specimen; Staining method; Stains; Structure; System; Technology; TimeLine; Tissue Microarray; Tissues; Training; Translational Research; Translations; Tumor Tissue; United States; Universities; Validation; Washington; Work; base; behavioral study; biobank; cancer specimen resource; cancer therapy; college; drug development; epidemiology study; experience; improved; innovation; insight; interest; multidisciplinary; new technology; novel diagnostics; novel marker; novel strategies; novel therapeutic intervention; operation; programs; prospective; public health relevance; repository; response; sample collection; success; therapeutic target; trend; tumor; virtual; web site

DESCRIPTION (provided by applicant): The National Cancer Institute (NCI) established the AIDS and Cancer Specimen Resource (ACSR) in 1994 to support the collection and expert preservation of clinically-annotated biospecimens for multidisciplinary research, bridging laboratory basic science with clinical, behavioral, and epidemiological studies. For the past 19 years, the ACSR has provided the foundation for successful translational research reliant on consistent access to high-quality well-annotated biospecimens. It has accomplished this via development of extensive expertise in methods for specimen collection and maintenance including specimen stability and full functionality overtime. The ACSR remains crucial to HIV-translational research, expanding services to researchers, and instituting practices to complement innovative new experimental directions by global HIV investigators. Since 2008, the current grant cycle, ACSR banked over 50,000 and distributed over 10,000 biospecimens to scientists worldwide. ACSR has also developed unique programs, offering project consultation and researcher training at all levels that assist with specimen choice and inform about biorepository procedures, thus ensuring appropriate handling and use of valuable biospecimens for research. The work accomplished under the current ACSR will be leveraged and transitioned to achieve the Specific Aims for the new ACSR to: 1) develop and maintain the ACSR infrastructure that allows efficient translation of the overall ACSR mission (to support current and future trends in HIV/AIDS malignancy research) to an ongoing functional program 2) provide scientific leadership, expand utilization and relevance of the resource; 3) acquire, maintain and distribute a diverse collection of high-quality and well-annotated biospecimens and; 4) support initiatives, projects, programs and collections, both national and international through ACSR services. To accomplish these aims we will restructure the current ACSR to a single multisite ACSR, under the direction of the Office of the Chairs (OC) and administered by the Central Operations and Data Coordinating Center (CODCC) to be led by senior investigators in a shared leadership role, Drs. Michael McGrath and Sylvia Silver, representing the continuing UCSF and George Washington University (GW) Regional Biospecimen Repositories (RBR). The two original RBRs, UCSF and GW, account for > 80% of the overall ACSR inventory (500,000+ specimens) and for supplying 90% of the specimens disbursed to researchers in the past five years. The proposed ACSR also will add value through transitioning affiliate programs at the University of Arizona, Tucson, and Baylor College of Medicine to new RBRs. The ACSR will continue to evolve and streamline operations to incorporate a state of the art inventory system, and new technologies and methods to improve specimen viability. The ACSR is a dynamic entity that has used innovative and novel approaches to meet changes in the epidemic and research directions, and is well positioned to continue support of current and future trends in HIV research that will have a positive impact on diagnosis and management of HIV-malignancies worldwide.

描述（由申请人提供）：美国国家癌症研究所（NCI）于1994年建立了艾滋病和癌症标本资源（ACSR），以支持多学科研究的临床注释生物标本的收集和专家保存，将实验室基础科学与临床，行为和流行病学研究联系起来。在过去的19年里，ACSR为成功的转化研究提供了基础，这些研究依赖于持续获得高质量的注释良好的生物标本。它通过在标本采集和维护方法（包括标本稳定性和全功能性）方面开发广泛的专业知识来实现这一目标。ACSR对于HIV转化研究，扩大对研究人员的服务以及制定实践以补充全球HIV研究人员的创新实验方向仍然至关重要。自2008年以来，目前的赠款周期，ACSR银行超过50，000和分发超过10，000生物标本给世界各地的科学家。ACSR还制定了独特的计划，提供各级项目咨询和研究人员培训，协助标本选择并告知生物储存程序，从而确保适当处理和使用有价值的生物标本进行研究。根据现行的建筑地盘工程检讨完成的工作，将会被利用及过渡，以达致新建筑地盘工程检讨的特定目标：1）发展及维持建筑地盘工程检讨的基础设施，使建筑地盘工程检讨的整体使命得以有效地转化（支持艾滋病毒/艾滋病恶性肿瘤研究的当前和未来趋势）到一个正在进行的功能计划2）提供科学领导，扩大资源的利用和相关性; 3）获取，维护和分发高质量和注释良好的生物标本的多样化收藏; 4）通过ACSR服务支持国家和国际的倡议，项目，计划和收藏。为了实现这些目标，我们将把目前的ACSR重组为一个单一的多地点ACSR，在主席办公室（OC）的指导下，由中央运营和数据协调中心（CODCC）管理，由高级研究人员共同领导，Michael麦格拉思和Sylvia银博士，代表持续的UCSF和乔治华盛顿大学（GW）区域生物标本库（RBR）。UCSF和GW这两个原始的RBRs占整个ACSR库存（500，000多个样本）的80%以上，并在过去五年中提供了90%的样本。拟议的ACSR还将通过将亚利桑那大学图森分校和贝勒医学院的附属项目过渡到新的RBRs来增加价值。ACSR将继续发展和简化操作，以纳入最先进的库存系统，以及新的技术和方法，以提高标本的生存能力。ACSR是一个充满活力的实体，采用创新和新颖的方法来满足流行病和研究方向的变化，并有能力继续支持艾滋病毒研究的当前和未来趋势，这将对全球艾滋病毒恶性肿瘤的诊断和管理产生积极影响。