AIDS and Cancer Specimen Resource (ACSR)
艾滋病和癌症样本资源 (ACSR)
基本信息
- 批准号:10248375
- 负责人:
- 金额:$ 479.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-23 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS Malignancy ConsortiumAIDS related cancerAIDS/HIV problemAcquired Immunodeficiency SyndromeAdherenceAdultAffectAfrica South of the SaharaAfrican AmericanAreaArizonaBasic ScienceBiologicalBiological Specimen BanksCaribbean regionCause of DeathCessation of lifeClinicalClinical DataClinical ResearchClinical TrialsCollaborationsCollectionComplexConsentDataData PoolingDevelopmentEconomic BurdenEnsureEpidemicEquipment and supply inventoriesEvolutionFosteringFreezingFundingGeographic LocationsGoalsGrowthHIVHeadHealthHepatitis B VirusHepatitis C virusHispanic AmericansHodgkin DiseaseHuman Herpesvirus 4Human PapillomavirusIncidenceIndividualInfectionInformaticsInstitutionInternationalInvestigationKaposi SarcomaLatin AmericaLatin AmericanLeadershipLinkLiquid substanceMalignant NeoplasmsMalignant neoplasm of anusMalignant neoplasm of cervix uteriMalignant neoplasm of lungMarketingMedical EconomicsMethodologyMissionMorbidity - disease rateNetwork InfrastructureNon-Hodgkin&aposs LymphomaOutcomePathogenesisPathologicPatientsPersonsPlayPrevalenceProcessPublic HealthReportingResearchResearch PersonnelResearch SupportResourcesRiskRisk FactorsRoleSample SizeSamplingScienceScientistSiteSmokingSpecimenStandardizationStructureTechnologyTestingTimeTissue SampleTranslational ResearchTumor TissueU-Series Cooperative AgreementsUnited StatesUnited States National Institutes of HealthUniversitiesViralWashingtonWorkaging populationantiretroviral therapybiobankbiological specimen archivescancer epidemiologycancer riskcancer specimen resourcecancer therapycancer typeco-infectionepidemiologic datafitnessimmune functioninformatics infrastructuremenmortalitynew technologynovelolder patientoutreachprogramssample collectionskillssuccesstumor microenvironmentvirtualvirtual repositoryvirus related cancerworking group
项目摘要
Abstract
The AIDS epidemic, initially recognized in the early 1980's, currently affects more than 35 million people
worldwide. Infection with the human immunodeficiency virus (HIV) is associated with a wide range of long term
health complications including the development of cancer, currently a major cause of death among persons living
with HIV/AIDS. The early form of the AIDS and Cancer Specimen Resource (ACSR) was established in 1994 as
a cooperative agreement with the NCI with a mission to provide high quality biospecimens to researchers, a
mission still paramount for the current ACSR.
Principle investigators (MPIs) from the two legacy sites (GWU and UCSF) oversee the function of the ACSR to
ensure the adherence to NCI best practices in this multinational program. The ACSR is currently the custodian
for specimen collections from more than 20,000 individuals and makes these biospecimens available to eligible
researchers studying HIV and cancer through an established specimen application process. In the past five
years, investigators from more than 50 institutions have received research material from the ACSR. In addition,
the ACSR has provided the centralized biospecimen collection and distribution functions for the AIDS Malignancy
Consortium (AMC), which represents the NCI-funded international network of more than 30 clinical institutions
involved in testing novel cancer therapies in HIV-infected individuals. The ACSR is structured into regional
biospecimen repositories (RBRs) located in distinct geographical regions that reflect the US and global HIV
epidemic and are unified (virtually) by an informatics infrastructure managed by the Hub for Integrated
Informatics and Research Support (HIIRS). The RBRs are distinct but complementary in their diverse functions,
with collaborative interactions fostered through the Governing Committee and ACSR-wide Working Groups that
accomplish activities related to Science and Technology, Marketing and Outreach, Informatics, and Quality
Management.
As the HIV epidemic has evolved the types of cancers and the technologies used to study them have also
changed. The newly reconfigured ACSR will have two divisions, both focused on obtaining the most important
well-annotated (demographic, clinical, pathological and outcomes data) biospecimens for research as defined
by investigator inquiries and the ACSR's scientific advisory board. The two MPIs, respectively will head the
national and international AMC support program and the scientific direction of the ACSR. Both MPIs will work
within the structure of the ACSR to obtain and provide to researcher's specimens most important for research in
the current epidemic. Specific Aims include: 1) Acquire, store, and equitably distribute tumor tissues and
biological fluids from individuals with HIV-associated malignancies (AIDS-defining cancers and non-AIDS
defining cancers) to meet the biospecimen needs of researchers in HIV-associated malignancies; and 2)
Promote the success of AMC clinical trials through mutually beneficial collaborations.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL Shannon MCGRATH其他文献
MICHAEL Shannon MCGRATH的其他文献
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{{ truncateString('MICHAEL Shannon MCGRATH', 18)}}的其他基金
Pathogenesis of the cART unresponsive Kaposi’s sarcoma tumor niche
cART 无反应卡波西肉瘤肿瘤微环境的发病机制
- 批准号:
10669148 - 财政年份:2019
- 资助金额:
$ 479.71万 - 项目类别:
Pathogenesis of the cART unresponsive Kaposi’s sarcoma tumor niche
cART 无反应卡波西肉瘤肿瘤微环境的发病机制
- 批准号:
9756172 - 财政年份:2019
- 资助金额:
$ 479.71万 - 项目类别:
Pathogenesis of the cART unresponsive Kaposi’s sarcoma tumor niche
cART 无反应卡波西肉瘤肿瘤微环境的发病机制
- 批准号:
10475259 - 财政年份:2019
- 资助金额:
$ 479.71万 - 项目类别:
Pathogenesis of the cART unresponsive Kaposi’s sarcoma tumor niche
cART 无反应卡波西肉瘤肿瘤微环境的发病机制
- 批准号:
10020368 - 财政年份:2019
- 资助金额:
$ 479.71万 - 项目类别:
Pathogenesis of the cART unresponsive Kaposi’s sarcoma tumor niche
cART 无反应卡波西肉瘤肿瘤微环境的发病机制
- 批准号:
10245125 - 财政年份:2019
- 资助金额:
$ 479.71万 - 项目类别:
Molecular Features of and Approach to the HIV CNS Reservoir Post cART
cART 后 HIV 中枢神经系统储库的分子特征和方法
- 批准号:
8544157 - 财政年份:2013
- 资助金额:
$ 479.71万 - 项目类别:
Molecular Features of and Approach to the HIV CNS Reservoir Post cART
cART 后 HIV 中枢神经系统储库的分子特征和方法
- 批准号:
9315921 - 财政年份:2013
- 资助金额:
$ 479.71万 - 项目类别:
相似海外基金
NCI AIDS RELATED CANCER COHORT STUDY (ACCS)
NCI 艾滋病相关癌症队列研究 (ACCS)
- 批准号:
6566071 - 财政年份:2001
- 资助金额:
$ 479.71万 - 项目类别:
NCI AIDS RELATED CANCER COHORT STUDY (ACCS)
NCI 艾滋病相关癌症队列研究 (ACCS)
- 批准号:
6423242 - 财政年份:2000
- 资助金额:
$ 479.71万 - 项目类别:
NCI AIDS RELATED CANCER COHORT STUDY (ACCS)
NCI 艾滋病相关癌症队列研究 (ACCS)
- 批准号:
6504219 - 财政年份:2000
- 资助金额:
$ 479.71万 - 项目类别:
NCI AIDS RELATED CANCER COHORT STUDY (ACCS)
NCI 艾滋病相关癌症队列研究 (ACCS)
- 批准号:
6303902 - 财政年份:1999
- 资助金额:
$ 479.71万 - 项目类别:
NCI AIDS RELATED CANCER COHORT STUDY (ACCS)
NCI 艾滋病相关癌症队列研究 (ACCS)
- 批准号:
6297230 - 财政年份:1998
- 资助金额:
$ 479.71万 - 项目类别:
NCI AIDS RELATED CANCER COHORT STUDY (ACCS)
NCI 艾滋病相关癌症队列研究 (ACCS)
- 批准号:
6263862 - 财政年份:1998
- 资助金额:
$ 479.71万 - 项目类别:
Search for specific modulators of the inflammatory resp onse in AIDS related cancer
寻找艾滋病相关癌症中炎症反应的特异性调节剂
- 批准号:
nhmrc : 960853 - 财政年份:1996
- 资助金额:
$ 479.71万 - 项目类别:
CARG - Research