AIDS and Cancer Specimen Resource (ACSR)

艾滋病和癌症样本资源 (ACSR)

• 批准号: 10248375
• 负责人: MICHAEL Shannon MCGRATH
• 金额: $ 479.71万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248375
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Adult; Affect; Africa South of the Sahara; African American; Area; Arizona; Basic Science; Biological; Biological Specimen Banks; Caribbean region; Cause of Death; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Collection; Complex; Consent; Data; Data Pooling; Development; Economic Burden; Ensure; Epidemic; Equipment and supply inventories; Evolution; Fostering; Freezing; Funding; Geographic Locations; Goals; Growth; HIV; Head; Health; Hepatitis B Virus; Hepatitis C virus; Hispanic Americans; Hodgkin Disease; Human Herpesvirus 4; Human Papillomavirus; Incidence; Individual; Infection; Informatics; Institution; International; Investigation; Kaposi Sarcoma; Latin America; Latin American; Leadership; Link; Liquid substance; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Marketing; Medical Economics; Methodology; Mission; Morbidity - disease rate; Network Infrastructure; Non-Hodgkin' s Lymphoma; Outcome; Pathogenesis; Pathologic; Patients; Persons; Play; Prevalence; Process; Public Health; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Science; Scientist; Site; Smoking; Specimen; Standardization; Structure; Technology; Testing; Time; Tissue Sample; Translational Research; Tumor Tissue; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Universities; Viral; Washington; Work; aging population; antiretroviral therapy; biobank; biological specimen archives; cancer epidemiology; cancer risk; cancer specimen resource; cancer therapy; cancer type; co-infection; epidemiologic data; fitness; immune function; informatics infrastructure; men; mortality; new technology; novel; older patient; outreach; programs; sample collection; skills; success; tumor microenvironment; virtual; virtual repository; virus related cancer; working group

Abstract The AIDS epidemic, initially recognized in the early 1980's, currently affects more than 35 million people worldwide. Infection with the human immunodeficiency virus (HIV) is associated with a wide range of long term health complications including the development of cancer, currently a major cause of death among persons living with HIV/AIDS. The early form of the AIDS and Cancer Specimen Resource (ACSR) was established in 1994 as a cooperative agreement with the NCI with a mission to provide high quality biospecimens to researchers, a mission still paramount for the current ACSR. Principle investigators (MPIs) from the two legacy sites (GWU and UCSF) oversee the function of the ACSR to ensure the adherence to NCI best practices in this multinational program. The ACSR is currently the custodian for specimen collections from more than 20,000 individuals and makes these biospecimens available to eligible researchers studying HIV and cancer through an established specimen application process. In the past five years, investigators from more than 50 institutions have received research material from the ACSR. In addition, the ACSR has provided the centralized biospecimen collection and distribution functions for the AIDS Malignancy Consortium (AMC), which represents the NCI-funded international network of more than 30 clinical institutions involved in testing novel cancer therapies in HIV-infected individuals. The ACSR is structured into regional biospecimen repositories (RBRs) located in distinct geographical regions that reflect the US and global HIV epidemic and are unified (virtually) by an informatics infrastructure managed by the Hub for Integrated Informatics and Research Support (HIIRS). The RBRs are distinct but complementary in their diverse functions, with collaborative interactions fostered through the Governing Committee and ACSR-wide Working Groups that accomplish activities related to Science and Technology, Marketing and Outreach, Informatics, and Quality Management. As the HIV epidemic has evolved the types of cancers and the technologies used to study them have also changed. The newly reconfigured ACSR will have two divisions, both focused on obtaining the most important well-annotated (demographic, clinical, pathological and outcomes data) biospecimens for research as defined by investigator inquiries and the ACSR's scientific advisory board. The two MPIs, respectively will head the national and international AMC support program and the scientific direction of the ACSR. Both MPIs will work within the structure of the ACSR to obtain and provide to researcher's specimens most important for research in the current epidemic. Specific Aims include: 1) Acquire, store, and equitably distribute tumor tissues and biological fluids from individuals with HIV-associated malignancies (AIDS-defining cancers and non-AIDS defining cancers) to meet the biospecimen needs of researchers in HIV-associated malignancies; and 2) Promote the success of AMC clinical trials through mutually beneficial collaborations.

摘要 艾滋病的流行最初是在20世纪80年代初被认识到的S，目前影响着3500多万人 全世界。感染人类免疫缺陷病毒(HIV)与一系列长期的 健康并发症，包括癌症的发展，目前是活人死亡的主要原因 感染艾滋病毒/艾滋病。艾滋病和癌症标本资源(ACSR)的早期形式成立于1994年，当时是 与NCI的合作协议，其使命是向研究人员提供高质量的生物标本，a 对于目前的ACSR来说，使命仍然是至高无上的。 来自两个遗产地(GWU和UCSF)的首席调查员(MPI)监督ACSR的职能，以 确保遵守NCI在此跨国计划中的最佳实践。ACSR目前是托管人 收集了20,000多个个体的标本，并向符合条件的人提供这些生物标本 研究人员通过既定的样本申请程序研究艾滋病毒和癌症。在过去的五年中 多年来，来自50多个机构的调查人员收到了ACSR的研究材料。此外, ACSR为艾滋病恶性肿瘤提供了集中的生物标本收集和分发功能 联盟(AMC)，代表NCI资助的由30多家临床机构组成的国际网络 参与在艾滋病毒感染者身上测试新的癌症疗法。ACSR的结构分为地区性的 位于不同地理区域的生物信息库(RBR)反映了美国和全球的艾滋病毒 并由集成中心管理的信息基础设施统一(虚拟) 信息学和研究支持(HIIRS)。成果管理制是不同的，但在其不同的职能方面是互补的， 通过管理委员会和ACSR范围内的工作组促进协作互动， 完成与科技、市场推广、信息学和质量相关的活动 管理层。 随着艾滋病毒流行的演变，癌症的类型和用于研究它们的技术也 变化。新重组的ACSR将有两个部门，两者都专注于获得最重要的 注解良好的(人口学、临床、病理和结果数据)用于研究的生物标本 由调查员调查和ACSR的科学顾问委员会。这两位MPI将分别领导 国家和国际AMC支持计划和ACSR的科学方向。两个MPI都可以工作 在ACSR的结构内获得并向研究人员提供对 当前的流行病。具体目标包括：1)获取、存储和公平分配肿瘤组织和 来自艾滋病毒相关恶性肿瘤(艾滋病定义的癌症和非艾滋病)患者的生物液 定义癌症)以满足艾滋病毒相关恶性肿瘤研究人员的生物样品需求；以及2) 通过互利合作促进AMC临床试验的成功。