AIDS and Cancer Specimen Resource (ACSR)

艾滋病和癌症样本资源 (ACSR)

• 批准号: 10248375
• 负责人: MICHAEL Shannon MCGRATH
• 金额: $ 479.71万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248375
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Adult; Affect; Africa South of the Sahara; African American; Area; Arizona; Basic Science; Biological; Biological Specimen Banks; Caribbean region; Cause of Death; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Collection; Complex; Consent; Data; Data Pooling; Development; Economic Burden; Ensure; Epidemic; Equipment and supply inventories; Evolution; Fostering; Freezing; Funding; Geographic Locations; Goals; Growth; HIV; Head; Health; Hepatitis B Virus; Hepatitis C virus; Hispanic Americans; Hodgkin Disease; Human Herpesvirus 4; Human Papillomavirus; Incidence; Individual; Infection; Informatics; Institution; International; Investigation; Kaposi Sarcoma; Latin America; Latin American; Leadership; Link; Liquid substance; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Marketing; Medical Economics; Methodology; Mission; Morbidity - disease rate; Network Infrastructure; Non-Hodgkin' s Lymphoma; Outcome; Pathogenesis; Pathologic; Patients; Persons; Play; Prevalence; Process; Public Health; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Science; Scientist; Site; Smoking; Specimen; Standardization; Structure; Technology; Testing; Time; Tissue Sample; Translational Research; Tumor Tissue; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Universities; Viral; Washington; Work; aging population; antiretroviral therapy; biobank; biological specimen archives; cancer epidemiology; cancer risk; cancer specimen resource; cancer therapy; cancer type; co-infection; epidemiologic data; fitness; immune function; informatics infrastructure; men; mortality; new technology; novel; older patient; outreach; programs; sample collection; skills; success; tumor microenvironment; virtual; virtual repository; virus related cancer; working group

Abstract The AIDS epidemic, initially recognized in the early 1980's, currently affects more than 35 million people worldwide. Infection with the human immunodeficiency virus (HIV) is associated with a wide range of long term health complications including the development of cancer, currently a major cause of death among persons living with HIV/AIDS. The early form of the AIDS and Cancer Specimen Resource (ACSR) was established in 1994 as a cooperative agreement with the NCI with a mission to provide high quality biospecimens to researchers, a mission still paramount for the current ACSR. Principle investigators (MPIs) from the two legacy sites (GWU and UCSF) oversee the function of the ACSR to ensure the adherence to NCI best practices in this multinational program. The ACSR is currently the custodian for specimen collections from more than 20,000 individuals and makes these biospecimens available to eligible researchers studying HIV and cancer through an established specimen application process. In the past five years, investigators from more than 50 institutions have received research material from the ACSR. In addition, the ACSR has provided the centralized biospecimen collection and distribution functions for the AIDS Malignancy Consortium (AMC), which represents the NCI-funded international network of more than 30 clinical institutions involved in testing novel cancer therapies in HIV-infected individuals. The ACSR is structured into regional biospecimen repositories (RBRs) located in distinct geographical regions that reflect the US and global HIV epidemic and are unified (virtually) by an informatics infrastructure managed by the Hub for Integrated Informatics and Research Support (HIIRS). The RBRs are distinct but complementary in their diverse functions, with collaborative interactions fostered through the Governing Committee and ACSR-wide Working Groups that accomplish activities related to Science and Technology, Marketing and Outreach, Informatics, and Quality Management. As the HIV epidemic has evolved the types of cancers and the technologies used to study them have also changed. The newly reconfigured ACSR will have two divisions, both focused on obtaining the most important well-annotated (demographic, clinical, pathological and outcomes data) biospecimens for research as defined by investigator inquiries and the ACSR's scientific advisory board. The two MPIs, respectively will head the national and international AMC support program and the scientific direction of the ACSR. Both MPIs will work within the structure of the ACSR to obtain and provide to researcher's specimens most important for research in the current epidemic. Specific Aims include: 1) Acquire, store, and equitably distribute tumor tissues and biological fluids from individuals with HIV-associated malignancies (AIDS-defining cancers and non-AIDS defining cancers) to meet the biospecimen needs of researchers in HIV-associated malignancies; and 2) Promote the success of AMC clinical trials through mutually beneficial collaborations.

摘要 1980年代初最初认识到的艾滋病流行病目前影响着3500多万人 国际吧人类免疫缺陷病毒（HIV）感染与多种长期 健康并发症，包括癌症的发展，这是目前生活在贫困地区的人的主要死亡原因。 艾滋病毒/艾滋病。艾滋病和癌症标本资源（ACSR）的早期形式成立于1994年， 与NCI达成合作协议，其使命是为研究人员提供高质量的生物标本， 使命仍然是当前ACSR的首要任务。 来自两个遗留研究中心（GWU和UCSF）的主要研究者（MPI）监督ACSR的功能， 确保在这个跨国项目中遵守NCI最佳实践。艺术与文化艺术委员会目前是 从超过20，000个人的标本采集，并将这些生物标本提供给符合条件的人 研究人员通过既定的标本应用程序研究艾滋病毒和癌症。过去五 多年来，来自50多个机构的研究人员收到了来自ACSR的研究材料。此外，本发明还提供了一种方法， 该中心为艾滋病研究中心提供了集中的生物标本收集和分发功能 联盟（AMC），代表了由30多家临床机构组成的NCI资助的国际网络 参与测试艾滋病毒感染者的新型癌症疗法。艺术与文化策略检讨的架构分为 生物标本库（RBRs）位于不同的地理区域，反映了美国和全球的艾滋病毒 流行病和统一（虚拟）的信息基础设施管理的枢纽， 信息学和研究支持（HIIRS）。成果预算报告各有不同，但在其不同的职能方面是互补的， 通过管理委员会和ACSR范围内的工作组促进合作互动， 完成与科学技术、市场营销和推广、信息学和质量相关的活动 管理 随着艾滋病毒流行的演变，癌症的类型和用于研究它们的技术也发生了变化。 变了新重组的ACSR将有两个部门，都专注于获得最重要的 注释良好的（人口统计学、临床、病理学和结局数据）生物标本，用于定义的研究 由调查员调查和ACSR的科学顾问委员会。这两个主要工业生产者将分别领导 国家和国际AMC支持计划以及ACSR的科学方向。两个MPI都将工作 在ACSR的结构，以获得和提供给研究人员的标本最重要的研究， 目前的流行病。具体目的包括：1）获取、储存和公平分配肿瘤组织， 来自患有HIV相关恶性肿瘤（AIDS定义的癌症和非AIDS定义的癌症）的个体的生物流体 定义癌症），以满足HIV相关恶性肿瘤研究人员的生物标本需求;以及2） 通过互利合作促进AMC临床试验的成功。