The Enigmatic Chloride Ion: Transport, Regulation, and Roles in Physiology

神秘的氯离子：运输、调节和生理学中的作用

• 批准号: 8597833
• 负责人: NAEL A MCCARTY
• 金额: $ 0.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597833
• 关键词: Achievement; Address; Animal Model; Anions; Area; Award; Berlin; Bioinformatics; Biological; Biology; Budgets; Carrier Proteins; Cells; Chickens; Chloride Channels; Chloride Ion; Chlorides; Cities; Collaborations; Commit; Communication; Cystic Fibrosis; Disease; Dissection; Ensure; Ethnic group; Family; Fostering; Funding; Germany; Goals; Government; Health; Human; Individual; Information Dissemination; Institution; International; Ion Channel; Ion Transport; Joints; Laboratories; Marines; Massachusetts; Mission; Modeling; Molecular; Molecular Evolution; Molecular Medicine; National Institute of Neurological Disorders and Stroke; Nature; Outcome; Participant; Pathway interactions; Pharmacologic Substance; Physiology; Play; Postdoctoral Fellow; Proteins; Public Health; Publishing; Regulation; Request for Proposals; Research; Research Personnel; Role; Science; Scientist; Senior Scientist; Societies; Staging; Structural Biologist; Structure; Students; Time; Travel; United States National Institutes of Health; Universities; Woman; Wood material; Work; base; career; design; egg; innovation; insight; meetings; member; men; novel; posters; programs; public health relevance; retinal rods; structural biology; success; symposium; therapeutic development; tool; yeast genetics

DESCRIPTION (provided by applicant): This proposal requests funds to support an international symposium on the biology of chloride entitled: "The Enigmatic Chloride Ion: Transport, Regulation, and Roles in Physiology" to be held on September 4-8, 2013, at the Marine Biological Laboratory in Woods Hole, MA. This meeting will comprise the Annual Symposium of the Society of General Physiologists (SGP). The annual symposium of the SGP has established its legacy as being the premier and most innovative meeting for physiologists, cell biologists, structural biologists, and biophysicists worldwide that span across all career stages and professional arenas. Recent groundbreaking discoveries demonstrating the pivotal role of chloride in human physiology and disease have led to great insights regarding chloride and its regulation, although this has also opened up a wide array of new questions. With typically d200 participants, SGP symposia are large enough to provide detailed and in depth analyses of a focused area of research, while at the same time being small enough to maximize individual discussions and foster collaborative interactions between students, postdoctoral fellows, new investigators, and established leaders within the field. An ambitious program has been developed for this meeting, enriched both by the list of highly-acclaimed speakers and by the addition of certain features not typical to these symposia. Included in the latter is: (1) a debate on the role of ClC chloride channels in lysosomal acidification to be engaged in by Drs. Thomas Jentsch (Berlin, Germany) and Joseph Mindell (NINDS); (2) a summation by Dr. Criss Hartzell (Emory University), and (3) a reserved last-minute session for presentation of new atomic structures not yet published. The symposium is designed around seven half-day "Sessions" including: (a) Chicken vs. Egg: Evolutionary relationships between channels and transporters, (b) Models & tools for studying chloride transport in health and disease, (c) Molecular families & regulation, and (d) Atypical anion transporters and channels. In most cases, these are led off with a thematic overview by a leader in that field. The Keynote Address, on the first day, will be given by Dr. Rod MacKinnon (Rockefeller Univ.) on the structural biology of chloride-transport proteins. Of note, the agenda includes a presentation from Dr. Fred VanGoor (Vertex Pharmaceuticals) who has led the successful development of therapeutics against Cystic Fibrosis, a chloride channel disease. These topics represent an integration of physiology and medicine from molecular to human levels with a special emphasis on elevating the pace of discovery by approaches that target chloride transport proteins of relevance to health and disease. We expect that this conference will attract approximately 150-200 basic and translational scientists across all career stages working at the cutting edge of ion channel research. The SGP and the members of the organizing committee are poised to ensure the success of this Symposium. It is our aim that through open dialogue and communication, new and important ideas and novel therapies will emerge as a direct result of this meeting.

描述(由申请者提供)：本提案请求资金支持2013年9月4-8日在马萨诸塞州伍兹霍尔海洋生物实验室举行的题为“神秘的氯离子：运输、调节和在生理学中的作用”的氯离子生物学国际研讨会。本次会议将包括全科生理学家协会(SGP)的年度研讨会。SGP的年度研讨会确立了其作为全球生理学家、细胞生物学家、结构生物学家和生物物理学家的首屈一指和最具创新性的会议的遗产，该会议跨越了所有职业阶段和专业领域。最近突破性的发现证明了氯在人类生理和疾病中的关键作用，这导致了对氯及其调控的深刻见解，尽管这也打开了一系列新的问题。SGP研讨会通常有200人参加，规模足够大，可以提供对重点研究领域的详细和深入的分析，同时也足够小，可以最大限度地进行个人讨论，促进学生、博士后研究员、新的研究人员和该领域内知名领导者之间的协作互动。为这次会议制定了一个雄心勃勃的计划，丰富了广受好评的发言者名单，并增加了这些研讨会的一些不典型的特点。后者包括：(1)将由Thomas Jentsch博士(德国柏林)和Joseph Mindell博士(NINDS)参与的关于ClC氯通道在溶酶体酸化中的作用的辩论；(2)Criss Hartzell博士(埃默里大学)的总结；以及(3)为介绍尚未发表的新原子结构而保留的最后一分钟会议。研讨会围绕七个半天的会议设计，包括：(A)鸡与蛋：通道和转运体之间的进化关系，(B)研究健康和疾病中氯离子转运的模型和工具，(C)分子家族和调控，以及(D)非典型阴离子转运体和通道。在大多数情况下，这些会议都是由该领域的领导者以主题概述开始的。第一天的主旨演讲将由洛克菲勒大学的罗德·麦金农博士发表。氯转运蛋白的结构生物学研究。值得注意的是，议程包括Vertex制药公司的Fred VanGoor博士的演讲，他领导了治疗囊性纤维化的成功开发，囊性纤维化是一种氯离子通道疾病。这些主题代表了从分子到人类层面的生理学和医学的整合，特别强调通过以与健康和疾病相关的氯运输蛋白为目标的方法来提高发现的速度。我们预计这次会议将吸引大约150-200名从事离子通道研究前沿工作的各个职业阶段的基础和转化型科学家。SGP和组委会成员已做好准备，确保本次研讨会取得成功。我们的目标是，通过公开对话和沟通，新的和重要的想法和新的治疗方法将作为这次会议的直接结果出现。