The Enigmatic Chloride Ion: Transport, Regulation, and Roles in Physiology

描述（由申请人提供）：本提案要求提供资金，以支持将于2013年9月4日至8日在马萨诸塞州伍兹霍尔的海洋生物实验室举行的题为“神秘的氯离子：运输，调节和生理学作用”的氯化物生物学国际研讨会。这次会议将包括普通生理学家协会（SGP）的年度研讨会。SGP的年度研讨会已经确立了其遗产，成为生理学家，细胞生物学家，结构生物学家和全球生物学家的首要和最具创新性的会议，跨越所有职业阶段和专业领域。最近的突破性发现证明了氯化物在人体生理学和疾病中的关键作用，导致了对氯化物及其调节的深刻见解，尽管这也带来了一系列新的问题。与典型的d200参与者，SGP专题讨论会是足够大，以提供详细和深入的分析研究的一个重点领域，而在同一时间足够小，以最大限度地提高个人讨论和促进学生之间的协作互动，博士后研究员，新的研究人员，并建立在该领域的领导者。为这次会议制定了一项雄心勃勃的计划，由于有了一份备受赞誉的发言者名单，并增加了一些专题讨论会所不具备的特点，这项计划更加丰富。后者包括：（1）托马斯·詹奇博士（柏林，德国）和约瑟夫·明德尔博士（NINDS）参与的关于C1 C氯离子通道在溶酶体酸化中的作用的辩论;（2）克里斯·哈泽尔博士（埃默里大学）的总结;（3）为尚未发表的新原子结构的介绍保留的最后一分钟会议。研讨会围绕七个半天的“会议”设计，包括：（a）鸡与蛋：通道和转运蛋白之间的进化关系，（B）研究健康和疾病中氯离子转运的模型和工具，（c）分子家族和调节，以及（d）非典型阴离子转运蛋白和通道。在大多数情况下，这些都是由该领域的领导者以主题概述开始的。主题演讲，在第一天，将由博士罗德麦金农（洛克菲勒大学）。氯离子转运蛋白的结构生物学。值得注意的是，议程包括Fred VanGoor博士（Vertex Pharmaceuticals）的演讲，他领导了针对囊性纤维化（一种氯离子通道疾病）的治疗方法的成功开发。这些主题代表了从分子到人类水平的生理学和医学的整合，特别强调通过靶向与健康和疾病相关的氯离子转运蛋白的方法来提高发现的速度。我们预计，本次会议将吸引大约150-200名基础和翻译科学家在各个职业阶段的离子通道研究的前沿工作。政治革新党和组织委员会成员已做好准备，确保这次专题讨论会取得成功。我们的目标是，通过公开对话和交流，新的和重要的想法和新的疗法将作为本次会议的直接结果出现。

DESCRIPTION (provided by applicant): This proposal requests funds to support an international symposium on the biology of chloride entitled: "The Enigmatic Chloride Ion: Transport, Regulation, and Roles in Physiology" to be held on September 4-8, 2013, at the Marine Biological Laboratory in Woods Hole, MA. This meeting will comprise the Annual Symposium of the Society of General Physiologists (SGP). The annual symposium of the SGP has established its legacy as being the premier and most innovative meeting for physiologists, cell biologists, structural biologists, and biophysicists worldwide that span across all career stages and professional arenas. Recent groundbreaking discoveries demonstrating the pivotal role of chloride in human physiology and disease have led to great insights regarding chloride and its regulation, although this has also opened up a wide array of new questions. With typically d200 participants, SGP symposia are large enough to provide detailed and in depth analyses of a focused area of research, while at the same time being small enough to maximize individual discussions and foster collaborative interactions between students, postdoctoral fellows, new investigators, and established leaders within the field. An ambitious program has been developed for this meeting, enriched both by the list of highly-acclaimed speakers and by the addition of certain features not typical to these symposia. Included in the latter is: (1) a debate on the role of ClC chloride channels in lysosomal acidification to be engaged in by Drs. Thomas Jentsch (Berlin, Germany) and Joseph Mindell (NINDS); (2) a summation by Dr. Criss Hartzell (Emory University), and (3) a reserved last-minute session for presentation of new atomic structures not yet published. The symposium is designed around seven half-day "Sessions" including: (a) Chicken vs. Egg: Evolutionary relationships between channels and transporters, (b) Models & tools for studying chloride transport in health and disease, (c) Molecular families & regulation, and (d) Atypical anion transporters and channels. In most cases, these are led off with a thematic overview by a leader in that field. The Keynote Address, on the first day, will be given by Dr. Rod MacKinnon (Rockefeller Univ.) on the structural biology of chloride-transport proteins. Of note, the agenda includes a presentation from Dr. Fred VanGoor (Vertex Pharmaceuticals) who has led the successful development of therapeutics against Cystic Fibrosis, a chloride channel disease. These topics represent an integration of physiology and medicine from molecular to human levels with a special emphasis on elevating the pace of discovery by approaches that target chloride transport proteins of relevance to health and disease. We expect that this conference will attract approximately 150-200 basic and translational scientists across all career stages working at the cutting edge of ion channel research. The SGP and the members of the organizing committee are poised to ensure the success of this Symposium. It is our aim that through open dialogue and communication, new and important ideas and novel therapies will emerge as a direct result of this meeting.