The Enigmatic Chloride Ion: Transport, Regulation, and Roles in Physiology

描述（由申请人提供）：本提案请求资金支持氯离子生物学的国际研讨会：“神秘的氯离子：运输，调节和生理作用”，将于2013年9月4日至8日在马萨诸塞州伍兹霍尔海洋生物实验室举行。本次会议将包括普通生理学家协会（SGP）年度研讨会。SGP的年度研讨会已经建立了它的遗产，作为生理学家，细胞生物学家，结构生物学家和生物物理学家的首要和最具创新性的会议，跨越了所有的职业阶段和专业领域。最近的突破性发现表明氯化物在人体生理和疾病中的关键作用，使人们对氯化物及其调控有了深刻的认识，尽管这也开辟了一系列广泛的新问题。SGP研讨会通常有200名参与者，规模足够大，可以对一个重点研究领域提供详细和深入的分析，同时规模也足够小，可以最大限度地进行个人讨论，并促进学生、博士后、新研究者和该领域的知名领导者之间的合作互动。为这次会议制定了一项雄心勃勃的计划，不仅有广受好评的演讲者，而且还增加了一些在这些专题讨论会中不常见的特点，使计划更加充实。后者包括：(1)关于ClC氯离子通道在溶酶体酸化中的作用的辩论。Thomas Jentsch（德国柏林）和Joseph Mindell (NINDS)；(2)由埃默里大学的克里斯·哈泽尔（Criss Hartzell）博士作总结，(3)为尚未发表的新原子结构的介绍预留最后一分钟的时间。研讨会围绕七个为期半天的“会议”进行设计，包括：(a)鸡与蛋：通道和转运体之间的进化关系，(b)研究健康和疾病中的氯化物转运的模型和工具，(c)分子家族和调控，以及(d)非典型阴离子转运体和通道。在大多数情况下，这些活动都由该领域的领导者进行专题概述。第一天的主题演讲将由罗德·麦金农博士（洛克菲勒大学）发表，主题是氯化物转运蛋白的结构生物学。值得注意的是，会议议程包括Fred VanGoor博士（Vertex制药公司）的演讲，他成功开发了一种氯离子通道疾病囊性纤维化的治疗方法。这些主题代表了从分子到人类水平的生理学和医学的整合，特别强调通过针对与健康和疾病相关的氯化物转运蛋白的方法来提高发现的速度。我们预计这次会议将吸引大约150-200名在离子通道研究前沿工作的各个职业阶段的基础和转化科学家。SGP和组委会成员将确保本次研讨会的成功。我们的目标是，通过公开的对话和交流，新的和重要的想法和新的治疗方法将作为这次会议的直接结果出现。

DESCRIPTION (provided by applicant): This proposal requests funds to support an international symposium on the biology of chloride entitled: "The Enigmatic Chloride Ion: Transport, Regulation, and Roles in Physiology" to be held on September 4-8, 2013, at the Marine Biological Laboratory in Woods Hole, MA. This meeting will comprise the Annual Symposium of the Society of General Physiologists (SGP). The annual symposium of the SGP has established its legacy as being the premier and most innovative meeting for physiologists, cell biologists, structural biologists, and biophysicists worldwide that span across all career stages and professional arenas. Recent groundbreaking discoveries demonstrating the pivotal role of chloride in human physiology and disease have led to great insights regarding chloride and its regulation, although this has also opened up a wide array of new questions. With typically d200 participants, SGP symposia are large enough to provide detailed and in depth analyses of a focused area of research, while at the same time being small enough to maximize individual discussions and foster collaborative interactions between students, postdoctoral fellows, new investigators, and established leaders within the field. An ambitious program has been developed for this meeting, enriched both by the list of highly-acclaimed speakers and by the addition of certain features not typical to these symposia. Included in the latter is: (1) a debate on the role of ClC chloride channels in lysosomal acidification to be engaged in by Drs. Thomas Jentsch (Berlin, Germany) and Joseph Mindell (NINDS); (2) a summation by Dr. Criss Hartzell (Emory University), and (3) a reserved last-minute session for presentation of new atomic structures not yet published. The symposium is designed around seven half-day "Sessions" including: (a) Chicken vs. Egg: Evolutionary relationships between channels and transporters, (b) Models & tools for studying chloride transport in health and disease, (c) Molecular families & regulation, and (d) Atypical anion transporters and channels. In most cases, these are led off with a thematic overview by a leader in that field. The Keynote Address, on the first day, will be given by Dr. Rod MacKinnon (Rockefeller Univ.) on the structural biology of chloride-transport proteins. Of note, the agenda includes a presentation from Dr. Fred VanGoor (Vertex Pharmaceuticals) who has led the successful development of therapeutics against Cystic Fibrosis, a chloride channel disease. These topics represent an integration of physiology and medicine from molecular to human levels with a special emphasis on elevating the pace of discovery by approaches that target chloride transport proteins of relevance to health and disease. We expect that this conference will attract approximately 150-200 basic and translational scientists across all career stages working at the cutting edge of ion channel research. The SGP and the members of the organizing committee are poised to ensure the success of this Symposium. It is our aim that through open dialogue and communication, new and important ideas and novel therapies will emerge as a direct result of this meeting.