2013 Directed Cell Migration Gordon Research Conference & Gordon Research Seminar

2013年定向细胞迁移戈登研究会议

• 批准号: 8459154
• 负责人: Peter Friedl
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8459154
• 关键词: Address; Animal Model; Animals; Area; Biological Models; Biomedical Engineering; Cells; Chemicals; Chemotaxis; Collaborations; Computer Simulation; Development; Dictyostelium; Discipline; Disease; Environment; Evolution; Experimental Models; Goals; Health; Homeostasis; Host Defense; Human; Immigration; Immune; In Vitro; Inflammation; Intention; Leukocyte Trafficking; Life; Link; Malignant Neoplasms; Modeling; Morphogenesis; Neoplasm Metastasis; Pathogenesis; Pathologic; Postdoctoral Fellow; Principal Investigator; Process; Protein Biochemistry; Regulation; Research; Research Personnel; Scholarship; Scientist; Series; Shapes; Special Event; Structure; Therapeutic; Tissues; Underrepresented Minority; Woman; Wound Healing; abstracting; career; career development; cell motility; experience; graduate student; in vivo; in vivo Model; intercellular communication; intravital microscopy; lectures; mathematical model; meetings; migration; model development; novel; novel strategies; polarized cell; posters; programs; public health relevance; symposium; three-dimensional modeling; tissue repair; trafficking

DESCRIPTION (provided by applicant): The 2013 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Directed Cell Migration will be held from January 19-25, 2013 in Galveston, TX, USA, continuing this biennial GRC series since 2005. The conference addresses how cells polarize and migrate directionally in vitro and in vivo. The topics range from protein biochemistry, cell signaling and migration to intravital microscopy in the living animal. The themes cover normal and pathologic cell migration in development, leukocyte trafficking, wound healing, and cancer metastasis and further include the use of microdevices and in-silico models to identify mechanisms of cell migration, and therapeutic approaches targeting cell migration and its contribution to disease. The program highlights shared and divergent mechanisms that steer single-cell versus collective cell migration, environments (2D, 3D) and models (in vitro, in vivo), and their implications for function and malfunction of cells. The conference will emphasize new concepts about the regulation of cell migration, and will explore links and differences between cell migration during development, wound healing, immune cell trafficking, and cancer. The combination of interdisciplinary speakers and topics has been selected with the specific intention of stimulating new ideas and collaborations in the field of cel migration and chemotaxis research, with focus on novel, unpublished findings. Besides world-known experts, young group leaders (Michael Sixt, Anna Kashina, Stephanie Alexander, Ewa Paluch, Xavier Trepat, Andrew Ewald) will present invited lectures. Talks from up to 20 young investigators selected from the submitted abstracts will allow for strong support and exposure of graduate students, post doc and junior principal investigators. Scholarships will be offered to encourage the attendance of young scientists, women and underrepresented minorities. Throughout the conference, interactions between senior and young investigators will be promoted in both formal and informal settings. This GRC is the first of this series to be preceded by a GRS on directed cell migration, organized by young researchers (Antoine Khalil, Michael Weiger), with focus on critical reviewing of how experimental models have shaped (and limited) concepts in cell migration research. The GRS will be opened by Peter Devreotes, founding chair of this GRC series in 2005, by discussing the evolution of paradigms in chemotaxis and directed cell migration research. The closing GRS lecture will be given by Michael Sixt, on how chemotaxis and haptotaxis are regulated during migration in 3D environments. Eight talks selected from the abstracts and two poster sessions will allow for engaged interactions and discussions. Two special events include a talk by Anna Kashina about her personal experience as scientist and professional novel writer, and an informal "Ask the PI" seminar with the Chairs and Keynote Speakers on career development in the field of cell migration. For both, the GRC and GRS, support will assure that the meeting will be successful and will provide much needed sponsorship for outstanding young scientists who wish to attend.

描述（由申请人提供）：2013年戈登研究会议（GRC）和戈登研究研讨会（GRS）定向细胞迁移将于2013年1月19日至25日在美国德克萨斯州加尔维斯顿举行，延续自2005年以来两年一度的GRC系列。会议讨论了细胞如何在体外和体内定向生长和迁移。主题范围从蛋白质生物化学，细胞信号和迁移到活体动物的活体显微镜。主题涵盖正常和病理性细胞迁移的发展，白细胞运输，伤口愈合和癌症转移，并进一步包括使用微型设备和计算机模型，以确定细胞迁移的机制，以及针对细胞迁移及其对疾病的贡献的治疗方法。该计划强调了引导单细胞与集体细胞迁移，环境（2D，3D）和模型（体外，体内）的共享和分歧机制，以及它们对细胞功能和功能障碍的影响。 会议将强调有关细胞迁移调节的新概念，并将探讨发育过程中细胞迁移、伤口愈合、免疫细胞贩运和癌症之间的联系和差异。选择跨学科演讲者和主题的组合是为了激发细胞迁移和趋化性研究领域的新想法和合作，重点是新颖的，未发表的发现。除了世界知名的专家外，年轻的小组领导人（迈克尔·西克特、安娜·卡希娜、斯蒂芬妮·亚历山大、埃瓦·帕卢奇、泽维尔·特雷帕特、安德鲁·埃瓦尔德）将应邀讲课。从提交的摘要中选出的多达20名年轻研究人员的演讲将为研究生，博士后和初级主要研究人员提供强有力的支持和曝光。将提供奖学金，以鼓励年轻科学家、妇女和代表性不足的少数民族参加。在整个会议期间，将在正式和非正式场合促进高级和年轻调查人员之间的互动。 这个GRC是这个系列中的第一个，之前是一个关于定向细胞迁移的GRS，由年轻的研究人员（Antoine Khalil，Michael Weiger）组织，重点是对实验模型如何在细胞迁移研究中塑造（和限制）概念的批判性评论。GRS将由2005年GRC系列的创始主席Peter Devreotes主持开幕，讨论趋化性和定向细胞迁移研究范式的演变。GRS的闭幕演讲将由Michael Sixt主讲，讲述在3D环境中迁移过程中趋化性和趋触性是如何调节的。从摘要和两个海报会议中选出的八个演讲将允许参与互动和讨论。两个特别活动包括安娜卡希娜关于她作为科学家和专业小说作家的个人经历的演讲，以及与主席和主旨发言人关于细胞迁移领域职业发展的非正式“问PI”研讨会。 对全球研究理事会和全球研究系统而言，支持将确保会议取得成功，并将为希望出席会议的杰出青年科学家提供急需的赞助。