2013 Directed Cell Migration Gordon Research Conference & Gordon Research Seminar

描述(由申请者提供)：2013年关于定向细胞迁移的戈登研究会议(GRC)和戈登研究研讨会(GRS)将于2013年1月19日至25日在美国德克萨斯州加尔维斯顿举行，延续自2005年以来的这一两年一度的GRC系列。会议讨论了细胞在体外和体内如何极化和定向迁移。主题涵盖从蛋白质生物化学、细胞信号和迁移到活体动物的活体显微镜。这些主题涵盖发育中的正常和病理细胞迁移、白细胞运输、伤口愈合和癌症转移，并进一步包括使用微型设备和电子计算机模型来确定细胞迁移的机制，以及针对细胞迁移及其对疾病的贡献的治疗方法。该计划重点介绍了共同和不同的机制，这些机制引导单个细胞与集体细胞迁移，环境(2D，3D)和模型(体外，体内)，以及它们对细胞功能和故障的影响。会议将强调有关细胞迁移调控的新概念，并将探讨发育过程中细胞迁移、伤口愈合、免疫细胞运输和癌症之间的联系和区别。选择跨学科演讲者和主题的组合是为了刺激细胞迁移和趋化研究领域的新想法和合作，重点是新的、未发表的发现。除了世界知名的专家外，年轻的小组领导人(Michael Sixt、Anna Kashina、Stephanie Alexander、Ewa Paluch、Xavier Trepat、Andrew Ewald)将主持特邀讲座。从提交的摘要中挑选出最多20名年轻研究人员的演讲将允许研究生、博士后和初级主要研究人员的大力支持和曝光。将提供奖学金，鼓励年轻科学家、妇女和代表性不足的少数群体参加。在整个会议期间，将在正式和非正式环境中促进高级和年轻调查人员之间的互动。本GRC是本系列之前的第一次关于定向细胞迁移的GRS，由年轻的研究人员(Antoine Khalil，Michael Weiger)组织，重点是对实验模型如何形成(和限制)细胞迁移研究中的概念进行批判性审查。GRS将由2005年GRC系列的创始主席Peter Devreotes主持开幕，他将讨论趋化和定向细胞迁移研究范式的演变。GRS的闭幕演讲将由Michael Sixt主讲，主题是3D环境中的迁徙过程中趋化性和触觉趋性是如何受到调节的。从摘要中挑选的八个演讲和两个海报会议将允许互动和讨论。两个特别活动包括安娜·卡希娜关于她作为科学家和专业小说作家的个人经历的演讲，以及与主席和主旨演讲者就细胞迁移领域的职业发展举行的非正式的“询问派”研讨会。对于GRC和GRS来说，支持将确保会议取得成功，并将为希望参加会议的杰出年轻科学家提供急需的赞助。

DESCRIPTION (provided by applicant): The 2013 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Directed Cell Migration will be held from January 19-25, 2013 in Galveston, TX, USA, continuing this biennial GRC series since 2005. The conference addresses how cells polarize and migrate directionally in vitro and in vivo. The topics range from protein biochemistry, cell signaling and migration to intravital microscopy in the living animal. The themes cover normal and pathologic cell migration in development, leukocyte trafficking, wound healing, and cancer metastasis and further include the use of microdevices and in-silico models to identify mechanisms of cell migration, and therapeutic approaches targeting cell migration and its contribution to disease. The program highlights shared and divergent mechanisms that steer single-cell versus collective cell migration, environments (2D, 3D) and models (in vitro, in vivo), and their implications for function and malfunction of cells. The conference will emphasize new concepts about the regulation of cell migration, and will explore links and differences between cell migration during development, wound healing, immune cell trafficking, and cancer. The combination of interdisciplinary speakers and topics has been selected with the specific intention of stimulating new ideas and collaborations in the field of cel migration and chemotaxis research, with focus on novel, unpublished findings. Besides world-known experts, young group leaders (Michael Sixt, Anna Kashina, Stephanie Alexander, Ewa Paluch, Xavier Trepat, Andrew Ewald) will present invited lectures. Talks from up to 20 young investigators selected from the submitted abstracts will allow for strong support and exposure of graduate students, post doc and junior principal investigators. Scholarships will be offered to encourage the attendance of young scientists, women and underrepresented minorities. Throughout the conference, interactions between senior and young investigators will be promoted in both formal and informal settings. This GRC is the first of this series to be preceded by a GRS on directed cell migration, organized by young researchers (Antoine Khalil, Michael Weiger), with focus on critical reviewing of how experimental models have shaped (and limited) concepts in cell migration research. The GRS will be opened by Peter Devreotes, founding chair of this GRC series in 2005, by discussing the evolution of paradigms in chemotaxis and directed cell migration research. The closing GRS lecture will be given by Michael Sixt, on how chemotaxis and haptotaxis are regulated during migration in 3D environments. Eight talks selected from the abstracts and two poster sessions will allow for engaged interactions and discussions. Two special events include a talk by Anna Kashina about her personal experience as scientist and professional novel writer, and an informal "Ask the PI" seminar with the Chairs and Keynote Speakers on career development in the field of cell migration. For both, the GRC and GRS, support will assure that the meeting will be successful and will provide much needed sponsorship for outstanding young scientists who wish to attend.