Is acupuncture a viable alternative to medication in overactive bladder for an el

对于膀胱过度活动症患者来说，针灸是替代药物治疗的可行方法吗？

• 批准号: 8554286
• 负责人: Ilana Addis
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8554286
• 关键词: Acupuncture procedure; Address; Adverse effects; Affect; Age; Aging; Anti-Cholinergics; Case Series; Chronic; Client satisfaction; Communities; Comorbidity; Complementary and alternative medicine; Constipation; Data; Data Collection; Drops; Elderly; Elderly woman; Enrollment; Female; Frequencies; Functional disorder; Genetic Crossing Over; Goals; Grant; Health; High Prevalence; Impaired cognition; Incontinence; Increased frequency of micturition; Individual; Infectious Skin Diseases; International; Intervention; Lead; Life; Lower urinary tract; Measures; Medical; Mental Depression; Multicenter Trials; Nocturia; Nursing Homes; Operative Surgical Procedures; Outcome; Overactive Bladder; Participant; Patients; Perception; Pharmaceutical Preparations; Phase; Physical activity; Pilot Projects; Population; Prevalence; Protocols documentation; Quality of life; Questionnaires; Randomized; Randomized Controlled Clinical Trials; Regimen; Research; Research Design; Sleep disturbances; Societies; Specialist; Staging; Symptoms; Testing; Time; Treatment outcome; Urinary Incontinence; Urinary tract; Vision; Withdrawal; Woman; Women' s Group; Xerostomia; alternative treatment; arm; clinically significant; cost; design; dosage; evidence base; falls; flexibility; human old age (65+); innovation; knowledge base; micturition urgency; novel; older patient; post intervention; primary outcome; randomized trial; response; social; success; treatment effect; trial comparing

DESCRIPTION (provided by applicant): Is acupuncture a viable alternative to medication for overactive bladder in an elderly female population? This GEMSSTAR (R03) application addresses the goals stated by the NIA to help in the transition of specialists towards aging research. This project will address the priorities stated in three ways: (1) Innovation: This projet will attempt to increase the understanding of how a regimen of acupuncture, a novel intervention, for OAB in elderly women might function in a real world setting. This project will be a feasibility and acceptability study addressing concerns about patient tolerance of a regimen of acupuncture, as well as changes in quality of life and overall patient satisfaction with acupuncture. It is a required starting point needed to design larger trials of acupuncture for OAB in an elderly female population. (2) Significance: This project will lead to larger trials and strog evidence based results of acupuncture's effect on this common, chronic and debilitating problem. (3) Approach: It will enlarge the knowledge base in the field of acupuncture and complementary and alternative medicine (CAM) for a geriatric population with a rigorous study design and appropriate, well characterized and validated measures. The primary hypothesis of this non-inferiority trial is that acupuncture will provide an equal amount of symptom relief for OAB as medical therapy with fewer side effects. This project is the initial stage in testing that hypothesis. In this randomized trial with a secondary one-way crossover, forty women over the age of 65 with OAB will be allocated to either 8 weeks of acupuncture or 8 weeks of medical therapy for OAB. Those in the medical therapy arm will take a standardized dosage of medication daily. After 8 weeks of medication and a 2 week wash out period they will be transitioned to the 8 week acupuncture protocol. Those randomized to the acupuncture protocol will receive an eight week regimen of acupuncture. Every participant will be followed for 8 weeks post-acupuncture intervention. Each participant will complete symptom, side effect and quality of life questionnaires at enrollment and at set times through the intervention and post-intervention phase of the trial. OAB is a chronic and debilitating problem that is present in up to 30 percent of older community dwelling women and more than half of those living in nursing homes. This project will evaluate whether elderly women with OAB are willing to participate and adhere to treatment and data collection while enrolled in a trial comparing medication and acupuncture and provide preliminary data leading to larger multicenter trials in this field.

描述（由申请人提供）：针灸是否是老年女性人口过度活跃膀胱药物的可行替代品？该GEMSSTAR（R03）申请解决了NIA所规定的目标，以帮助专家向老化研究过渡。该项目将以三种方式解决优先事项：（1）创新：该计划将试图提高对OAB在老年妇女中如何在现实世界中起作用的针灸治疗方案，一种新颖的干预措施。这个项目将是 一项可行性和可接受性研究解决了对针灸治疗方案的耐受性的担忧，以及生活质量的变化以及患者对针灸的满意度。这是设计针灸对OAB的老年女性人口的较大针灸试验所需的起点。 （2）意义：该项目将导致针灸对这个常见，慢性和使人衰弱的问题的影响的基于跨越证据的结果。 （3）方法：它将扩大针灸和互补和替代医学（CAM）领域的知识基础，并具有严格的研究设计以及适当，表征良好和经过验证的措施。这项非效率试验的主要假设是，针灸将为OAB作为医疗疗法提供相同数量的症状，而副作用较少。该项目是检验该假设的初始阶段。在该随机试验的次要单向跨界试验中，有40名与OAB的女性将分配给OAB的8周针灸或8周的医疗治疗。医疗疗法部门的人每天​​将服用标准化的药物治疗。经过8周的药物治疗和2周洗涤期后，它们将过渡到8周的针灸方案。那些随机使用针灸方案的人将获得八周的针灸治疗方案。针灸干预后8周将遵循每个参与者。每个参与者将在入学率和设定的时间内完成症状，副作用和生活质量问卷，并在试验的干预和干预后阶段。 OAB是一个长期衰弱的问题，目前存在 30％的年长社区居住妇女和居住在疗养院的人中有一半以上。该项目将评估有OAB的老年妇女是否愿意参与并遵守治疗和数据收集，同时参加了比较药物和针灸的试验，并提供初步数据，从而在该领域进行大型多中心试验。