Is acupuncture a viable alternative to medication in overactive bladder for an el

对于膀胱过度活动症患者来说，针灸是替代药物治疗的可行方法吗？

• 批准号: 8554286
• 负责人: Ilana Addis
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8554286
• 关键词: Acupuncture procedure; Address; Adverse effects; Affect; Age; Aging; Anti-Cholinergics; Case Series; Chronic; Client satisfaction; Communities; Comorbidity; Complementary and alternative medicine; Constipation; Data; Data Collection; Drops; Elderly; Elderly woman; Enrollment; Female; Frequencies; Functional disorder; Genetic Crossing Over; Goals; Grant; Health; High Prevalence; Impaired cognition; Incontinence; Increased frequency of micturition; Individual; Infectious Skin Diseases; International; Intervention; Lead; Life; Lower urinary tract; Measures; Medical; Mental Depression; Multicenter Trials; Nocturia; Nursing Homes; Operative Surgical Procedures; Outcome; Overactive Bladder; Participant; Patients; Perception; Pharmaceutical Preparations; Phase; Physical activity; Pilot Projects; Population; Prevalence; Protocols documentation; Quality of life; Questionnaires; Randomized; Randomized Controlled Clinical Trials; Regimen; Research; Research Design; Sleep disturbances; Societies; Specialist; Staging; Symptoms; Testing; Time; Treatment outcome; Urinary Incontinence; Urinary tract; Vision; Withdrawal; Woman; Women' s Group; Xerostomia; alternative treatment; arm; clinically significant; cost; design; dosage; evidence base; falls; flexibility; human old age (65+); innovation; knowledge base; micturition urgency; novel; older patient; post intervention; primary outcome; randomized trial; response; social; success; treatment effect; trial comparing

DESCRIPTION (provided by applicant): Is acupuncture a viable alternative to medication for overactive bladder in an elderly female population? This GEMSSTAR (R03) application addresses the goals stated by the NIA to help in the transition of specialists towards aging research. This project will address the priorities stated in three ways: (1) Innovation: This projet will attempt to increase the understanding of how a regimen of acupuncture, a novel intervention, for OAB in elderly women might function in a real world setting. This project will be a feasibility and acceptability study addressing concerns about patient tolerance of a regimen of acupuncture, as well as changes in quality of life and overall patient satisfaction with acupuncture. It is a required starting point needed to design larger trials of acupuncture for OAB in an elderly female population. (2) Significance: This project will lead to larger trials and strog evidence based results of acupuncture's effect on this common, chronic and debilitating problem. (3) Approach: It will enlarge the knowledge base in the field of acupuncture and complementary and alternative medicine (CAM) for a geriatric population with a rigorous study design and appropriate, well characterized and validated measures. The primary hypothesis of this non-inferiority trial is that acupuncture will provide an equal amount of symptom relief for OAB as medical therapy with fewer side effects. This project is the initial stage in testing that hypothesis. In this randomized trial with a secondary one-way crossover, forty women over the age of 65 with OAB will be allocated to either 8 weeks of acupuncture or 8 weeks of medical therapy for OAB. Those in the medical therapy arm will take a standardized dosage of medication daily. After 8 weeks of medication and a 2 week wash out period they will be transitioned to the 8 week acupuncture protocol. Those randomized to the acupuncture protocol will receive an eight week regimen of acupuncture. Every participant will be followed for 8 weeks post-acupuncture intervention. Each participant will complete symptom, side effect and quality of life questionnaires at enrollment and at set times through the intervention and post-intervention phase of the trial. OAB is a chronic and debilitating problem that is present in up to 30 percent of older community dwelling women and more than half of those living in nursing homes. This project will evaluate whether elderly women with OAB are willing to participate and adhere to treatment and data collection while enrolled in a trial comparing medication and acupuncture and provide preliminary data leading to larger multicenter trials in this field.

描述（由申请人提供）：针灸是治疗老年女性膀胱过动症的可行替代药物吗？这个GEMSSTAR （R03）应用程序解决了NIA提出的帮助专家向老龄化研究过渡的目标。本项目将以三种方式解决优先事项：(1)创新：本项目将尝试增加对针灸治疗方案的理解，这是一种新颖的干预措施，对于老年妇女OAB在现实世界中的作用。这个项目将是