Interactive Effect of Environmental Exposures and Alcohol in the Navajo Birth Coh

环境暴露和酒精对纳瓦霍出生COH的交互影响

基本信息

批准号：
8496240
负责人：
Ludmila Nicole Bakhireva
金额：
$ 42.19万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8496240
关键词：
1 year old Address Affect Age Age-Years Alcohol abuse Alcohol dependence Alcohols American Indian and Alaska Native Arsenic Biological Markers Biological Monitoring Birth Child Cohort Studies Collaborations Communities Congresses Data Data Set Development Developmental Delay Disorders Diagnosis Early Intervention Early identification Environmental Exposure Environmental Pollution Environmental Risk Factor Esters Ethanol Evaluation Exposure to Fatty Acids Feces Fetal Alcohol Exposure Fetal Alcohol Spectrum Disorder Fetal alcohol effects Foundations Funding Future Glucuronides Goals Gold Growth Growth and Development function Head circumference Heavy Metals Height Home environment Lead Learning Left Life Maternal Age Maternal and Child Health Measures Meconium Metals Methods Mining National Institute on Alcohol Abuse and Alcoholism Native Americans Navajo Neurocognitive Neurocognitive Deficit Neurodevelopmental Deficit Newborn Infant Outcome Outcome Study Parents Patient Self-Report Perinatal Population Prevalence Prevention program Production Psyche structure Public Health Questionnaires Recommendation Recording of previous events Reporting Reproductive Health Resources Risk Risk Factors Sensitivity and Specificity Site Source Staging Surveys Testing Toxic Environmental Substances Toxicant exposure Tribes Uranium Validation War Water Water Pollution Weight Wit Work cohort cost effective diethyl sulfate disability disorder prevention drinking water experience health disparity improved innovation modifiable risk neurodevelopment neurotoxic northern plains novel operation population based prenatal prenatal environmental exposure programs public health relevance screening socioeconomics tribal community wasting weapons

项目摘要

DESCRIPTION (provided by applicant): American Indian/Alaska Natives (AI/AN) have historically experienced disparate rates of key reproductive health indicators. In addition, many AI tribes, especially in the western U.S., have been disproportionately affected by exposure to environmental contaminants, including but not limited to non-occupational exposures to uranium and other metal wastes such as arsenic resulting from past mining and milling operations and also from drinking water contamination. In addition, poor socioeconomic conditions affecting many tribal communities often lead to increased rates of alcohol abuse and dependence. While AI/AN are greatly underrepresented in the population-based and targeted screening programs, recent studies among AI of the Northern Plains suggest that the prevalence of the Fetal Alcohol Spectrum Disorder might be 10-fold higher than in the general U.S. population (May et al, 2008). The goal of this project is to partner with the Navajo Birth Cohort Study (NBCS; PI: Lewis) to assess a combined effect of prenatal alcohol, uranium, and arsenic exposure on growth and neurocognitive deficits in 600 Navajo children at 1 year of age. The central hypothesis is that alcohol will synergize with uranium and arsenic co-exposures to increase the risk of early growth and neurodevelopmental deficits at one year of age. The project will employ the state-of-the-art methods to confirm both environmental exposures and prenatal alcohol exposure (PAE) and is supported by Dr. Lewis's extensive preliminary data on uranium and arsenic exposure sources in the Navajo Nation and validation of ethanol biomarkers studies conducted by Dr. Bakhireva. Uranium and arsenic exposures will be determined through in- home environmental assessments, extensive surveys for exposure histories, and through biomonitoring confirmation of recent exposures. In addition to maternal self-report, PAE will be confirmed with a battery of one established (fatty acid ethyl ester [FAEE]) and two novel (ethyl glucuronide [EtG] and ethyl sulfate [EtS]) meconium biomarkers. The presence of FAEE in meconium at birth has been previously reported to be predictive of future mental and psychomotor delays in children, and a battery of three biomarkers is expected to improve sensitivity and specificity of the test. The innovation of the proposed work lies in partnering wit the established NBCS, employing a cost-effective strategy by leveraging NBCS resources, and working within an established, decade-long, community and academic partnership. The proposed study is, to our knowledge, the first attempt to objectively assess prevalence of prenatal alcohol exposure (PAE) and interaction between PAE and environmental toxicants in a Native American population. Both exposures represent potentially modifiable risk factors which might be the key players contributing to health disparities and poor perinatal outcomes in the Native American communities. If the hypothesis is supported by the study outcomes, the findings would have impact beyond the current population.

描述（由申请人提供）：美洲印第安人/阿拉斯加土著人（AI/AN）历史上经历了主要的生殖健康指标的不同率。此外，许多AI部落，尤其是在美国西部，受到暴露于环境污染物的影响，包括但不限于铀和其他金属废物的非占用暴露，例如由于过去的采矿和铣削操作以及饮用水污染而导致的砷。此外，影响许多部落社区的社会经济条件差常常导致酗酒和依赖性率提高。尽管AI/AN在基于人群和有针对性的筛查计划中的人为大大不足，但北部平原AI的最新研究表明，胎儿酒精谱系障碍的患病率可能比美国一般人群高10倍（May等人，2008年）。该项目的目的是与Navajo出生队列研究（NBCS; PI：Lewis）合作，以评估1岁纳瓦瓦儿童在600名Navajo儿童中对产前酒精，铀和砷暴露对生长和神经认知缺陷的综合作用。中心假设是，酒精将与铀和砷共膨化协同作用，以增加一岁时早期生长和神经发育缺陷的风险。该项目将采用最先进的方法来确认环境暴露和产前酒精暴露（PAE），并得到刘易斯博士在纳瓦霍（Navajo Nation）中有关铀和砷暴露源的广泛初步数据的支持，并验证了Bakhireva博士对乙醇生物标志物研究的验证。铀和砷暴露将通过家庭环境评估，广泛的暴露历史调查以及通过对最近暴露的生物监测确认来确定。除了母亲的自我报告外，PAE还将通过一池（脂肪酸乙基[FAEE]）和两个新型（乙基葡萄糖醛酸乙酯[ETG]和硫酸乙酯[ETS]）生物标志物确认。先前据报道，出生时胎粪中faee的存在可以预测儿童的未来心理和心理运动延迟，并且预计三种生物标志物的电池有望提高测试的敏感性和特异性。拟议工作的创新在于与已建立的NBC合作，通过利用NBCS资源并在已建立的，十年的社区和学术合作伙伴关系范围内采用成本效益的战略。据我们所知，拟议的研究是首次试图客观地评估产前酒精暴露（PAE）（PAE）以及美国原住民人口中PAE与环境毒物之间的相互作用的尝试。两种暴露都代表了可能改变的危险因素，这可能是对健康差异和美国原住民社区造成健康差异的关键参与者。如果该假设得到了研究结果的支持，那么这些发现将影响到当前人群之外。