Big Questions in Cognitive Aging: An Integrative Analysis Approach

认知老化的大问题：综合分析方法

• 批准号: 8573064
• 负责人: Alden L. Gross
• 金额: $ 8.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8573064
• 关键词: Address; Adult; Age; Age-associated memory impairment; Aging; Biological; Birth; Characteristics; Clinical Research; Cognition; Cognitive; Cognitive aging; Cohort Studies; Conflict (Psychology); Data; Data Analyses; Data Set; Data Sources; Dementia; Demographic Aging; Deterioration; Development; Differential Diagnosis; Education; Elderly; Elements; Epidemiologic Studies; Genetic; Goals; Health; Heterogeneity; Impaired cognition; Intervention; Measurement; Measures; Memory; Meta-Analysis; Methods; Neuropsychological Tests; Outcome; Patients; Performance; Population; Preparation; Property; Publishing; Race; Reporting; Research; Research Design; Retirement; Sample Size; Sampling; Scientific Advances and Accomplishments; Signs and Symptoms; Source; Study Section; Subgroup; Testing; Time; Work; age related; base; cognitive function; cohort; executive function; experience; follow-up; improved; neuropsychological; normal aging; performance tests; prevent; sex; sound; standardize measure; theories; trait; volunteer

DESCRIPTION (provided by applicant): The timing and magnitude of age-related cognitive decline, some of the oldest questions in cognitive aging research, remain open questions of major importance. Although many studies have been conducted, we often cannot compare results because they use different cognitive tests and are not directly comparable. The goal of this proposal is to conduct an integrative data analysis of cognitive aging, meaning drawing together data collected in multiple studies, made comparable by harmonizing traits for general cognitive function, memory, and executive function. We will use several large epidemiologic studies with longitudinal data that administered different neuropsychological test batteries. Cognitive performance will be scaled across study to a nationally representative sample of older adults. To approach this task, we have neuropsychological performance data from 10 epidemiologic and clinical studies of older adults, for a combined sample size of 39,832 adults between the ages of 55 and 110 who have been followed up to 20 years. The studies are a mix of representative, volunteer, and specially selected samples. Our goals in this proposal are to address the timing and magnitude of age-related cognitive decline, and to obtain support for continued development of the composites and eventual preparation of an R01 to address other major questions in cognitive aging. Before we can address such substantive research questions, substantial work is needed to evaluate bias and measurement properties of the harmonized composites. Our study team possesses necessary experience and unique capabilities to complete this work. We have already published the basics of our approach.

描述（由申请人提供）：与年龄相关的认知下降的时机和幅度，认知衰老研究中一些最古老的问题仍然是重要的问题。尽管已经进行了许多研究，但我们通常无法比较结果，因为它们使用了不同的认知测试，并且无法直接可比。该提案的目的是对认知衰老进行综合数据分析，这意味着将收集的数据汇总在一起，并通过协调特征的一般认知功能，记忆和执行功能来进行比较。我们将使用几项大型流行病学研究，并使用纵向数据来管理不同的神经心理测试电池。认知表现将在整个研究中扩展到全国代表性的老年人样本。为了应付这项任务，我们拥有来自老年人的10个流行病学和临床研究的神经心理表现数据，其中39,832名成年人的综合年龄在55至110岁之间，他们经过了20年的跟踪。这些研究是代表性，志愿者和特殊选择的样本的混合。我们在此提案中的目标是解决与年龄相关的认知下降的时机和幅度，并为持续发展复合材料的持续发展和最终准备R01的准备，以解决认知衰老中的其他主要问题。在我们解决此类实质性研究问题之前，需要进行大量工作来评估统一复合材料的偏见和测量特性。我们的学习团队拥有完成这项工作的必要经验和独特的能力。我们已经发布了我们方法的基础知识。