Intersection of Physiologic Frailty and Cognitive Performance in Older Adults: An Integrative Data Analysis

老年人生理虚弱与认知表现的交叉点：综合数据分析

• 批准号: 9889017
• 负责人: Alden L. Gross
• 金额: $ 12.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9889017
• 关键词: Adult; Age; Aging; Alzheimer' s Disease; Ancillary Study; Applications Grants; Architecture; Attention; Award; Biological; Biological Markers; Biology; Biology of Aging; Body Composition; Characteristics; Clinical; Cognition; Cognitive; Cognitive aging; Collaborations; Complex; Data; Data Analyses; Data Set; Deltastab; Dementia; Dimensions; Early Diagnosis; Early identification; Education; Elderly; Endocrine; Epidemic; Epidemiologist; Epidemiology; Ethnic Origin; Five-Year Plans; Funding; Future; Goals; Health; Health Status; Hospitalization; Impaired cognition; Impairment; Inflammatory; Intervention; K-Series Research Career Programs; Knowledge; Longitudinal Studies; Measures; Memory; Mentors; Methodology; Methods; Modeling; Nature; Performance; Physical activity; Physiological; Polypharmacy; Prevention strategy; Public Health Schools; Publications; Renin; Research; Research Personnel; Research Project Grants; Risk; Sampling; Services; Severities; Signs and Symptoms; Subgroup; Sympathetic Nervous System; Symptoms; System; Testing; Training; Training Programs; United States National Institutes of Health; Visit; Vitamin D; Work; adverse outcome; age related; aged; benefit sharing; biological adaptation to stress; body system; career; career development; clinical phenotype; clinical practice; cognitive performance; cognitive testing; cohort; design; disability; executive function; experience; follow-up; frailty; glucose metabolism; hypothalamic-pituitary-adrenal axis; informal learning; insight; longitudinal dataset; meetings; method development; mortality; multidisciplinary; novel; nutritional supplementation; patient population; patient screening; professor; prospective; public health intervention; public health relevance; screening; secondary analysis; sex; skills; working group

 DESCRIPTION (provided by applicant): Alden L. Gross is an Assistant Professor in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. He seeks a mentored career development award to obtain critical knowledge skills in the biology of aging, particularly as it relates to frailty in older adults, and necessary research experience for an independent career as an epidemiologist in aging. The training application details a five year plan of formal and informal instruction in the physiological basis of frailty and aging consisting f mentored research by an established team of experts, coursework, seminars, guided study in frailty by mentors, collaborations in richly educational working groups, national and local meetings, and mentored research informed by the training. Short-term career goals include to complete coursework in the biology of aging and practice, disseminate high-quality mentored research through publications and presentations, engage in career development activities, and apply for independent R01 funding beginning in the fourth year of the award period. Long-term career goals are to be an independent psychiatric epidemiologist with content expertise in the biology of aging, particularly as it relates to frailty in older adults. The specific aims of the research proposed are to develop and validate an objective method for measuring physiological frailty using combinations of physiological markers of dysregulation across multiple body systems in an integrative data analysis of three longitudinal datasets, to determine whether physiological frailty or cognitive impairment predicts subsequent change in the other, and to evaluate reciprocal relationship between changes in physiological frailty and cognitive decline with attention to implications for future public health interventions. An ancillary study is proposd to enrich existing biomarker data. Completion of the proposed aims will provide preliminary findings that will lay the groundwork for mounting interventions to establish frailty as a window o opportunity for intervention or screening of subsequent cognitive decline.

 描述（由适用提供）：Alden L. Gross是Johns Hopkins Bloomberg公共卫生学院流行病学系的助理教授。他寻求指导的职业发展奖，以获得衰老生物学的关键知识技能，尤其是与老年人的脆弱有关，并为 作为衰老的流行病学家的独立职业。培训申请详细介绍了一个五年的正式和非正式教学计划，以脆弱和衰老的身体为基础，由成熟的专家团队，课程，半手赛，少导师的指导性研究，丰富的教育工作组，国家和地方的合作，国家和地方会议的合作以及培训的指导研究。短期职业目标包括完成衰老和实践生物学的课程，通过出版物和演讲传播高质量的指导研究，从事职业发展活动，并申请从奖励期的第四年开始独立R01资金。长期的职业目标是成为衰老生物学的内容专家的独立精神病学家，尤其是与老年人的脆弱有关。提出的研究的具体目的是开发和验证一种客观的方法，该方法是在三个纵向数据集的综合数据分析中，使用多个身体系统的身体失调的物理标记的结合，以确定与其他人之间的关注和互联网之间的关注和差异之间的衰落，以确定与其他人之间的变化，并确定与其他人之间的衰落和认知之间的变化，并确定对差异的不断变化。提出了一项辅助研究来丰富现有的生物标志物数据。拟议的目标的完成将提供初步发现，这将为安装干预措施建立脆弱的窗户O的基础奠定基础。