Targeted Analyses of Jackson Heart Study Data

描述（由申请人提供）：杰克逊心脏研究（JHS）旨在收集临床，实验室，影像学，遗传和环境数据，这些数据可以为居住在杰克逊MS社区的非裔美国人（AA）的心血管和相关疾病的决定因素和发展提供见解。2000年至2012年期间，5301名AA男性和女性参加了基线和两次额外的临床检查。肥胖和糖尿病是心血管疾病和美国黑人与白人之间整体健康差异的重要因素。这两种情况在JHS注册的学生中都非常普遍。该提案的总体目标是提高JHS在肥胖/糖尿病及其心脏代谢和血管结局方面的科学产出。我们建议通过新成立的JHS肥胖糖尿病工作组（ODWG）的科学家对肥胖和糖代谢参数进行深入的横断面和纵向分析，并选择结局（糖尿病，亚临床和临床心血管疾病）。ODWG将作为一个虚拟团队，利用电话会议、面对面会议和基于互联网的文件共享工具，包括Wake Forest、JHS和其他感兴趣的调查人员和受训人员。调查小组包括流行病学、生物统计学、影像学、糖尿病、肥胖和心血管疾病方面的专家。我们与JHS也有现存的关系，因为维克森林大学是在测试2和3中进行的CT和MRI研究的阅读中心。发展小组活动的一个重点包括指导初级调查人员和受训人员。我们还期望这些数据的分析和传播将刺激对辅助研究的单独资助申请。

DESCRIPTION (provided by applicant): The Jackson Heart Study (JHS) was designed to collect clinical, laboratory, imaging, genetic, and environmental data that could provide insights into the determinants and development of cardiovascular and related diseases in African Americans (AA) residing in the Jackson, MS community. Between 2000 and 2012, 5301 AA men and women participated at a baseline and two additional clinic examinations. Obesity and diabetes are important contributors to cardiovascular outcomes and the overall health disparities observed between AAs and whites in the United States. Both conditions are highly prevalent among those enrolled in JHS. The overall goal of this proposal is to enhance the scientific output of the JHS with respect to obesity/diabetes and its cardiometabolic and vascular outcomes. We propose to conduct in-depth cross- sectional and longitudinal analyses of obesity and glucometabolic parameters, and select outcomes (incident diabetes, subclinical and clinical cardiovascular disease) by engaging scientists in the newly established JHS Obesity Diabetes Working Group (ODWG). The ODWG will function as a virtual team, utilizing a combination of teleconferences, in person meetings, and internet-based file sharing tools, and will include Wake Forest, JHS and other interested investigators and trainees. The investigative team includes expertise in epidemiology, biostatistics, imaging, diabetes, obesity, and cardiovascular disease. We also have an extant relationship with JHS as Wake Forest served as the reading center for the CT and MRI studies performed at exams 2 and 3. A focus of ODWG activities includes mentoring junior investigators and trainees. We also expect that analysis and dissemination of these data will spur the application for separate funding for ancillary studies.