Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor

用于 Cor 光谱 CT 成像的铋有机配合物靶向纳米颗粒

• 批准号: 8497716
• 负责人: Gregory M Lanza
• 金额: $ 19.31万
• 依托单位: OCEAN NANOTECH, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8497716
• 关键词: Accident and Emergency department; Acute; Anatomy; Animals; Arkansas; Attenuated; Beds; Biodistribution; Bismuth; Calcium; Canis familiaris; Cardiac; Cardiac Catheterization Procedures; Cardiovascular system; Chest Pain; Clinical; Collaborations; Complement; Complex; Coronary; Coronary heart disease; Coupling; Decision Making; Deposition; Development; Diagnosis; Disease; Drug Formulations; Drug Kinetics; Epitopes; Etiology; Fibrin; Fibrinogen; Floor; Goals; Healthcare; Heart Diseases; Home environment; Hospitals; Human; Human Development; Image; Immune; Individual; Life; Ligands; Lung; Materials Testing; Medical; Modeling; Musculoskeletal; Myocardial; Nanotechnology; Oceans; Oryctolagus cuniculus; Outcome; Patient Transfer; Patients; Peptides; Pharmacodynamics; Phase; Predictive Value; Preparation; Procedures; Process; Production; Proteins; Recording of previous events; Relative (related person); Research; Research Personnel; Risk; Rupture; Safety; Sterility; Stress Tests; Technology; Telemetry; Thrombosis; Thrombus; Toxic effect; Toxicity Tests; Universities; Validation; Washington; X-Ray Computed Tomography; attenuation; cost; evaluation/testing; follow-up; gastrointestinal; heart imaging; improved; in vivo; innovation; molecular imaging; nanomaterials; nanoparticle; novel; prototype; scale up; stability testing

DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress testing, or discharge home with medical follow-up. In this proposal, we hypothesize that a novel thrombus-specific Spectral Computed Tomography (Multicolored CT) nanoparticle (i.e., NanoK) approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma. This project, which is led by Ocean NanoTech in collaboration with Washington University, will complete development of a GLP-/GMP-ready 1- fibrin NanoK product candidate suitably advanced for GLP stability and toxicity testing to support an FDA IND. This NanoK platform technology offers unique benefits for diagnosis and treatment of acute coronary disease that could improve healthcare outcomes and reduce costs.

描述（由申请人提供）：在急诊科（ED）就诊的胸痛患者面临着一个临床困境：转院进行紧急冠状动脉血运重建术，住院过夜进行心脏遥测和压力测试，或出院回家接受医学随访。在这项提议中，我们假设一种新的血栓特异性光谱计算机断层扫描（彩色CT）纳米颗粒（即NanoK）方法可以直接快速评估ED中的冠状动脉疾病，有助于解决这一临床困境。该项目由Ocean NanoTech与华盛顿大学合作领导，将完成GLP / gmp准备的1-纤维蛋白NanoK候选产品的开发，该候选产品适用于GLP稳定性和毒性测试，以支持FDA IND。这种NanoK平台技术为急性冠状动脉疾病的诊断和治疗提供了独特的优势，可以改善医疗结果并降低成本。