Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor

描述(由申请人提供)：急诊科(ED)的胸痛患者面临临床困境：转院接受急诊冠状动脉血运重建，连夜入院接受心脏遥测和负荷测试，还是出院接受医疗随访。在这项建议中，我们假设一种新的血栓特异性频谱CT(多色CT)纳米颗粒(即NanOK)方法可以直接快速评估ED的冠状动脉疾病，可能有助于解决这一临床难题。该项目由Ocean NanoTech与华盛顿大学合作领导，将完成GLP/GMP就绪的1-纤维蛋白Nanok候选产品的开发，该候选产品适用于GLP稳定性和毒性测试，以支持FDA IND。这项Nanok平台技术为急性冠状动脉疾病的诊断和治疗提供了独特的好处，可以改善医疗保健结果并降低成本。

DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress testing, or discharge home with medical follow-up. In this proposal, we hypothesize that a novel thrombus-specific Spectral Computed Tomography (Multicolored CT) nanoparticle (i.e., NanoK) approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma. This project, which is led by Ocean NanoTech in collaboration with Washington University, will complete development of a GLP-/GMP-ready 1- fibrin NanoK product candidate suitably advanced for GLP stability and toxicity testing to support an FDA IND. This NanoK platform technology offers unique benefits for diagnosis and treatment of acute coronary disease that could improve healthcare outcomes and reduce costs.