Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor

描述（由申请人提供）：急诊科（艾德）就诊的胸痛患者面临临床困境：转移进行紧急冠状动脉血运重建，住院过夜进行心脏遥测和负荷测试，或出院回家进行医学随访。在该提议中，我们假设一种新的血栓特异性光谱计算机断层扫描（多色CT）纳米颗粒（即，NanoK）方法在艾德中直接快速评估冠状动脉疾病可以帮助解决这一临床难题。该项目由Ocean NanoTech与华盛顿大学合作领导，将完成GLP-/GMP就绪1-纤维蛋白NanoK产品候选产品的开发，该产品适用于GLP稳定性和毒性测试，以支持FDA IND。该NanoK平台技术为急性冠状动脉疾病的诊断和治疗提供了独特的优势，可以改善医疗保健结果并降低成本。

DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress testing, or discharge home with medical follow-up. In this proposal, we hypothesize that a novel thrombus-specific Spectral Computed Tomography (Multicolored CT) nanoparticle (i.e., NanoK) approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma. This project, which is led by Ocean NanoTech in collaboration with Washington University, will complete development of a GLP-/GMP-ready 1- fibrin NanoK product candidate suitably advanced for GLP stability and toxicity testing to support an FDA IND. This NanoK platform technology offers unique benefits for diagnosis and treatment of acute coronary disease that could improve healthcare outcomes and reduce costs.