2013 Cilia, Mucus and Mucociliary Interactions Gordon Research Conference

描述(申请人提供)：本申请请求部分支持将于2013年4月7日至12日在意大利的卢卡(巴尔加)举行的关于纤毛、粘液和粘液纤毛相互作用的会议。这是一次获得批准的戈登研究会议(GRC)，延续了2005年、2007年、2009年和2011年成功举办的GRC赞助和GRC批准的同名会议。这次会议继续提供了一个独特的重点，在活动纤毛，粘液和其他液体之间的相互作用，以及它们之间的相互作用，在人类健康、发育和疾病中发挥着如此重要的作用；对这些学科的专注和综合关注在任何其他科学场所都是找不到的。随着对所涉及的基本基本原则的理解日益加深，这些科学学科的重要性和相互联系日益得到承认。本次会议上发生的学科之间的相互作用对理解呼吸道疾病(例如囊性纤维化、哮喘、支气管炎、慢性阻塞性肺疾病和原发性纤毛运动障碍)以及涉及纤毛驱动的液体运动和细胞外信号梯度产生的关键发育过程(例如心、肺、脑和肾脏)具有重大影响。这次会议的总体组织基于非常成功的GRC形式，聚集了基础和临床科学家，从而为将研究成果转化为翻译水平提供了动力。具体目标是：1)聚集世界各地的专家和年轻的科学家，利用广泛的方法研究纤毛、粘液及其相互作用的基本方面；2)提供一个论坛，介绍新的研究成果和技术，交流思想和观点，并鼓励和促进基础、翻译和临床研究人员之间的互动和合作；3)将高通量基因组学/蛋白质组学和数学建模等新方法与纤毛和纤毛-流体相互作用研究中使用的更传统方法相结合；(4)通过合理和积极主动地规划和组织会议，确保妇女、少数群体、年轻研究人员(初级教员、研究员、博士后和博士后)以及残疾人有强有力和公平的代表权和参与权。会议将以两场全体讲座开始，讨论纤毛和粘液领域的当前范例，并强调这两个群体之间的串扰将特别有利的领域。接下来将讨论一)纤毛组装和粘液产生，二)纤毛/粘液相互作用的生物物理学，三)分化 纤毛和分泌细胞，iv)纤毛，流动和组织发育，v)基因组/蛋白质组/糖学方法研究纤毛疾病和粘液纤毛疾病，vi)纤毛/液体相互作用，vii)纤毛和粘液纤毛相互作用研究的新方法，以及)理解纤毛功能和粘液纤毛疾病的模型系统。

DESCRIPTION (provided by applicant): This application requests partial support for a conference on Cilia, Mucus and Mucociliary Interactions that will be held in Lucca (Barga), Italy from April 7-12 2013. This is an approved Gordon Research Conference (GRC) and continues the successful GRC-sponsored and GRC-approved conferences of the same name that were held in 2005, 2007, 2009 and 2011. This conference continues to provide a unique focus on the interplay between motile cilia, mucus and other fluids, and their interactions that play such an essential role in human health, development and disease; the dedicated and integrated focus on these disciplines is not found in any other scientific venue. The importance and inter-connection of these scientific disciplines has become increasingly recognized as understanding of the basic underlying principles involved has grown. The interplay between disciplines that occurs at this conference has a major impact on the understanding of respiratory tract diseases (e.g. cystic fibrosis, asthma, bronchitis, chronic obstructive pulmonary disease and primary ciliary dyskinesia) and also on key developmental processes (e.g. in heart, lung, brain and kidney) that involve the cilia-driven movement of fluids and generation of extracellular signaling gradients. The overall organization of this conference is based on the highly successful GRC format and brings together both basic and clinical scientists and thus provides a driving force for transitioning findings to the translational level. The specific objectives are to: 1) bring togethe both world experts and younger scientists studying fundamental aspects of cilia, mucus and their interactions using a broad array of methodologies; 2) provide a forum for the presentation of new research findings and technologies, the exchange of ideas and viewpoints and to stimulate and promote interactions and collaborations between basic, translational and clinical researchers; 3) to integrate new approaches such as high throughput genomics/proteomics and mathematical modeling with more traditional methods used in the study of cilia and cilia-fluid interactions; and 4) to ensure the strong and equitable representation and participation of women, minorities, young investigators (junior faculty, fellows, pre- and post-doctoral students) and those with disabilities through sound and proactive planning and organization of the meeting. The conference will start with two plenary lectures that will discuss the current paradigms of the cilia and mucus fields and highlight areas where crosstalk between these two communities will be particularly advantageous. This will be followed by sessions on i) ciliary assembly and mucus production, ii) the biophysics of cilia/mucus interactions, iii) differentiation of multiciliated and secretory cells, iv) cilia, flow and tissue development, v) genomic/proteomic/glycomic approaches to ciliopathies and muco-ciliary disease, vi) cilia/fluid interactions, vii) new approaches to the study of cilia and muco-ciliary interactions, and viii) model systems in understanding ciliary function and muco-ciliary disease.