2013 Cilia, Mucus and Mucociliary Interactions Gordon Research Conference

描述（由申请人提供）：本申请要求部分支持将于2013年4月7日至12日在意大利卢卡（巴尔加）举行的纤毛，粘液和粘膜纤毛相互作用会议。这是经批准的戈登研究会议（GRC），并延续了2005年、2007年、2009年和2011年成功举办的GRC赞助和GRC批准的同名会议。本次会议继续提供一个独特的焦点，关注运动纤毛、粘液和其他液体之间的相互作用，以及它们在人类健康、发育和疾病中发挥如此重要作用的相互作用；对这些学科的专注和综合关注在任何其他科学场所都找不到。随着对所涉及的基本基本原理的理解的增长，这些科学学科的重要性和相互联系已日益得到认识。本次会议上发生的学科之间的相互作用对呼吸道疾病（如囊性纤维化、哮喘、支气管炎、慢性阻塞性肺病和原发性纤毛运动障碍）的理解以及涉及纤毛驱动的液体运动和细胞外信号梯度产生的关键发育过程（如心脏、肺、脑和肾）具有重大影响。本次会议的总体组织是基于非常成功的GRC格式，汇集了基础和临床科学家，从而为将研究结果转化为转化水平提供了推动力。具体目标是：1)汇集世界专家和年轻科学家，使用广泛的方法研究纤毛，粘液及其相互作用的基本方面；2)提供一个论坛，展示新的研究成果和技术，交流思想和观点，刺激和促进基础、转化和临床研究人员之间的互动和合作；3)将高通量基因组学/蛋白质组学和数学建模等新方法与更传统的纤毛和纤毛-流体相互作用研究方法相结合；4)通过健全和积极的会议规划和组织，确保妇女、少数民族、年轻研究人员（初级教师、研究员、博士生和博士后）和残疾人的强大和公平的代表性和参与。会议将以两场全体演讲开始，讨论纤毛和黏液领域的当前范例，并强调这两个群体之间的相互交流将特别有利的领域。接下来的课程是：1)纤毛组装和粘液产生，2)纤毛/粘液相互作用的生物物理学，3)分化

DESCRIPTION (provided by applicant): This application requests partial support for a conference on Cilia, Mucus and Mucociliary Interactions that will be held in Lucca (Barga), Italy from April 7-12 2013. This is an approved Gordon Research Conference (GRC) and continues the successful GRC-sponsored and GRC-approved conferences of the same name that were held in 2005, 2007, 2009 and 2011. This conference continues to provide a unique focus on the interplay between motile cilia, mucus and other fluids, and their interactions that play such an essential role in human health, development and disease; the dedicated and integrated focus on these disciplines is not found in any other scientific venue. The importance and inter-connection of these scientific disciplines has become increasingly recognized as understanding of the basic underlying principles involved has grown. The interplay between disciplines that occurs at this conference has a major impact on the understanding of respiratory tract diseases (e.g. cystic fibrosis, asthma, bronchitis, chronic obstructive pulmonary disease and primary ciliary dyskinesia) and also on key developmental processes (e.g. in heart, lung, brain and kidney) that involve the cilia-driven movement of fluids and generation of extracellular signaling gradients. The overall organization of this conference is based on the highly successful GRC format and brings together both basic and clinical scientists and thus provides a driving force for transitioning findings to the translational level. The specific objectives are to: 1) bring togethe both world experts and younger scientists studying fundamental aspects of cilia, mucus and their interactions using a broad array of methodologies; 2) provide a forum for the presentation of new research findings and technologies, the exchange of ideas and viewpoints and to stimulate and promote interactions and collaborations between basic, translational and clinical researchers; 3) to integrate new approaches such as high throughput genomics/proteomics and mathematical modeling with more traditional methods used in the study of cilia and cilia-fluid interactions; and 4) to ensure the strong and equitable representation and participation of women, minorities, young investigators (junior faculty, fellows, pre- and post-doctoral students) and those with disabilities through sound and proactive planning and organization of the meeting. The conference will start with two plenary lectures that will discuss the current paradigms of the cilia and mucus fields and highlight areas where crosstalk between these two communities will be particularly advantageous. This will be followed by sessions on i) ciliary assembly and mucus production, ii) the biophysics of cilia/mucus interactions, iii) differentiation of multiciliated and secretory cells, iv) cilia, flow and tissue development, v) genomic/proteomic/glycomic approaches to ciliopathies and muco-ciliary disease, vi) cilia/fluid interactions, vii) new approaches to the study of cilia and muco-ciliary interactions, and viii) model systems in understanding ciliary function and muco-ciliary disease.