2013 Cilia, Mucus and Mucociliary Interactions Gordon Research Conference

描述（由申请人提供）：本申请请求对将于2013年4月7日至12日在意大利卢卡（巴尔加）举行的纤毛、粘液和粘膜纤毛相互作用会议提供部分支持。这是一个批准的戈登研究会议（GRC），并继续在2005年，2007年，2009年和2011年举行的成功的GRC赞助和GRC批准的同名会议。本次会议继续独特地关注活动纤毛、粘液和其他液体之间的相互作用，以及它们在人类健康、发育和疾病中发挥重要作用的相互作用;对这些学科的专门和综合关注是在任何其他科学场所都找不到的。随着对所涉基本原则的理解的加深，人们日益认识到这些科学学科的重要性和相互联系。在这次会议上发生的学科之间的相互作用对呼吸道疾病（例如囊性纤维化，哮喘，支气管炎，慢性阻塞性肺疾病和原发性纤毛运动障碍）的理解以及涉及纤毛驱动的液体运动和细胞外信号梯度产生的关键发育过程（例如在心脏，肺，大脑和肾脏）产生重大影响。本次会议的整体组织是基于非常成功的GRC格式，汇集了基础和临床科学家，从而为将发现转化为转化水平提供了动力。具体目标是：1）汇集世界专家和年轻科学家，使用广泛的方法研究纤毛，粘液及其相互作用的基本方面; 2）提供一个论坛，介绍新的研究成果和技术，交流思想和观点，并激励和促进基础，翻译和临床研究人员之间的互动和合作; 3）将高通量基因组学/蛋白质组学和数学建模等新方法与纤毛和纤毛-流体相互作用研究中使用的更传统的方法相结合;以及4）确保妇女、少数民族、年轻调查人员的强有力和公平的代表性和参与通过健全和积极主动地规划和组织会议，为青年教师、研究员、博士前和博士后学生以及残疾人提供了机会。会议将以两个全体讲座开始，讨论纤毛和粘液领域的当前范例，并突出这两个社区之间的串扰将特别有利的领域。随后将进行i）纤毛组装和粘液产生，ii）纤毛/粘液相互作用的生物物理学，iii）分化 多纤毛细胞和分泌细胞，iv）纤毛，流动和组织发育，v）纤毛病和粘膜纤毛疾病的基因组/蛋白质组学/糖组学方法，vi）纤毛/流体相互作用，vii）研究纤毛和粘膜纤毛相互作用的新方法，和viii）理解纤毛功能和粘膜纤毛疾病的模型系统。

DESCRIPTION (provided by applicant): This application requests partial support for a conference on Cilia, Mucus and Mucociliary Interactions that will be held in Lucca (Barga), Italy from April 7-12 2013. This is an approved Gordon Research Conference (GRC) and continues the successful GRC-sponsored and GRC-approved conferences of the same name that were held in 2005, 2007, 2009 and 2011. This conference continues to provide a unique focus on the interplay between motile cilia, mucus and other fluids, and their interactions that play such an essential role in human health, development and disease; the dedicated and integrated focus on these disciplines is not found in any other scientific venue. The importance and inter-connection of these scientific disciplines has become increasingly recognized as understanding of the basic underlying principles involved has grown. The interplay between disciplines that occurs at this conference has a major impact on the understanding of respiratory tract diseases (e.g. cystic fibrosis, asthma, bronchitis, chronic obstructive pulmonary disease and primary ciliary dyskinesia) and also on key developmental processes (e.g. in heart, lung, brain and kidney) that involve the cilia-driven movement of fluids and generation of extracellular signaling gradients. The overall organization of this conference is based on the highly successful GRC format and brings together both basic and clinical scientists and thus provides a driving force for transitioning findings to the translational level. The specific objectives are to: 1) bring togethe both world experts and younger scientists studying fundamental aspects of cilia, mucus and their interactions using a broad array of methodologies; 2) provide a forum for the presentation of new research findings and technologies, the exchange of ideas and viewpoints and to stimulate and promote interactions and collaborations between basic, translational and clinical researchers; 3) to integrate new approaches such as high throughput genomics/proteomics and mathematical modeling with more traditional methods used in the study of cilia and cilia-fluid interactions; and 4) to ensure the strong and equitable representation and participation of women, minorities, young investigators (junior faculty, fellows, pre- and post-doctoral students) and those with disabilities through sound and proactive planning and organization of the meeting. The conference will start with two plenary lectures that will discuss the current paradigms of the cilia and mucus fields and highlight areas where crosstalk between these two communities will be particularly advantageous. This will be followed by sessions on i) ciliary assembly and mucus production, ii) the biophysics of cilia/mucus interactions, iii) differentiation of multiciliated and secretory cells, iv) cilia, flow and tissue development, v) genomic/proteomic/glycomic approaches to ciliopathies and muco-ciliary disease, vi) cilia/fluid interactions, vii) new approaches to the study of cilia and muco-ciliary interactions, and viii) model systems in understanding ciliary function and muco-ciliary disease.