Immune responses to Norovirus after natural infection in Vietnamese children and

越南儿童和儿童自然感染后对诺如病毒的免疫反应

• 批准号: 8463872
• 负责人: Xi Jiang
• 金额: $ 4.89万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-25 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8463872
• 关键词: Acute; Address; Antibodies; Antigenic Variation; Antiviral Agents; Blood Group Antigens; Blood typing procedure; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Collaborations; Country; Data Analyses; Development; Diagnosis; Disease; Epidemiology; Evolution; Funding; Future; Gastroenteritis; Genetic Variation; Goals; Herd Immunity; Hospitalized Child; Human; Human Volunteers; Hygiene; Immune response; Immunity; Immunology; Income; Individual; Infection; Institutes; Integration Host Factors; International; Laboratories; Laboratory Diagnosis; Laboratory Personnel; Laboratory Research; Lead; Literature; Medical center; Norovirus; Norwalk virus; Ohio; Pattern; Pediatric Hospitals; Predisposition; Research; Research Personnel; Resistance; Resources; Role; Rotavirus; Safety; Seasons; Target Populations; Technology; Training; United States National Institutes of Health; Vaccines; Variant; Vietnam; Viral Gastroenteritis; Virus; antigen binding; base; career; community setting; genetic evolution; improved; influenzavirus; new technology; prototype; receptor; receptor binding; surveillance network; vaccine development; virus host interaction; volunteer

DESCRIPTION (provided by applicant): This FIRCA-BB application intends to having a capacity development of a LMIC laboratory (Nguyen Van Trang, co-PI) at the National Institute of Hygiene and Epidemiology (NIHE) in Vietnam on norovirus (NV) research through collaboration with a well established NV research laboratory at the Cincinnati Children's Hospital Medical Center (CCHMC, Jiang, PI) in Cincinnati, Ohio. We will perform field surveillance of NV associated gastroenteritis in Vietnamese children focusing on three currently urgent topics on the virus/host interaction, immunology and evolution of NVs. We will determine the correlation of histo-blood group antigen (HBGA) status with susceptibility to NVs in children hospitalized with acute gastroenteritis; access immune responses to NVs following natural infection of children in clinical and community settings; and study the role of host herd immunity in NV evolution by genetic and antigenic characterization of GII.4 variants in the Vietnamese children. To improve the research capacity of the LMIC laboratory, we will particularly focus on the improvement of the surveillance network, training of laboratory personnel, and transferring or adapting of new technology, including developing new ones based on needs of the LMIC laboratory. Our goal is to have the LMIC laboratory becoming a national reference laboratory and Dr. Trang the national leader in the NV and rotavirus researches in Vietnam.

描述（由申请人提供）：本FIRCA-BB申请旨在通过与辛辛那提俄亥俄州的辛辛那提儿童医院医学中心（CCHMC，Jiang，PI）的成熟NV研究实验室合作，对越南国家卫生和流行病学研究所（NIHE）的LMIC实验室（Nguyen货车Trang，co-PI）进行诺如病毒（NV）研究的能力开发。我们将对越南儿童NV相关胃肠炎进行现场监测，重点关注病毒/宿主相互作用、免疫学和NV演变这三个当前紧迫的主题。我们将确定组织血型抗原（HBGA）状态与急性胃肠炎住院儿童对NV易感性的相关性;在临床和社区环境中儿童自然感染后对NV的免疫反应;并通过越南儿童GII.4变异体的遗传和抗原特征研究宿主群体免疫在NV演变中的作用。为了提高LMIC实验室的研究能力，我们将特别注重改善监测网络，培训实验室人员，转让或采用新技术，包括根据LMIC实验室的需要开发新技术。我们的目标是使LMIC实验室成为国家参考实验室，使Trang博士成为越南NV和轮状病毒研究的国家领导者。