Multidisciplinary Clinical and Translational Science (MCTS) Program (TL1)

多学科临床和转化科学 (MCTS) 计划 (TL1)

• 批准号: 8666336
• 负责人: DONALD M LLOYD-JONES
• 金额: --
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-19 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8666336
• 关键词: Biological Sciences; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Communities; Community Health; Development; Discipline; Disease; Doctor of Philosophy; Education; Effectiveness; Engineering; Environment; Faculty; Fostering; Functional disorder; Funding; Goals; Health; Home environment; Human; Incentives; Interdisciplinary Study; Laboratories; Leadership; Link; Location; Master of Science; Medical Staff; Mentored Clinical Scientist Development Program; Mentors; Modeling; Nursing Research; Patient Care; Performance; Physiology; Positioning Attribute; Postdoctoral Fellow; Procedures; Research; Research Personnel; Research Training; Scientist; Solutions; Training; Training Programs; Training and Education; Translating; Translational Research; Universities; Work; base; career development; experience; improved; member; multidisciplinary; next generation; pre-doctoral; programs; success; tool

Why have there.not been more successes in translating exciting scientific discoveries into improved patient care and community health (1,2)? Possible explanations include a shortage and high turnover rate of clinicianinvestigators due to insufficient institutional and environmental support (3); reluctance to let go of the traditional department-centric research and training models; a lack of effectiveness in educating PhD scientists about the physiology and pathophysiology of human health and disease (4); and a gap in providing clinical and bench scientists with the tools needed to be successful in the current research environment, including working in interdisciplinary teams. In this section we propose solutions to these possible barriers and provide an implementation plan that is achievable and can be evaluated. The overall goal of this key component of our CTSA application is to create the next generation of clinical researchers representing multiple disciplines who will be boundary spanners, able to pollinate new ideas and link laboratories and investigators in different disciplines. Northwestern University has fostered interdisciplinary research for several decades. It has provided incentives including faculty positions and research funding to break the lines and barriers separating disciplines, and merged discipline-based graduate training programs in the life sciences and engineering into 4 integrated programs that span campus locations. We propose building on an already successful program of interdisciplinary research education, training and career development by establishing the Center for Clinical Research Education (CCRE). The Center will coordinate and enhance existing clinical and translational research education, training and career development activities; create new courses, seminars and programs and integrate them with existing activities; expand the candidate pool for our programs by including predoctoral trainees and .basic scientists; educate/train the candidates differently than in the past using an expanded set of course offerings and seminars and established interdisciplinary teams, and nurture the trainees using carefully chosen mentors and new oversight procedures including standardized tracking tools. The Center will also provide new opportunities for clinical research and regulatory staff and community investigators. The Center and its key programs will be led by a dynamic and experienced leadership team.

为什么在将令人兴奋的科学发现转化为改善患者的治疗方面没有取得更多成功 护理和社区健康 (1,2)？可能的解释包括临床医生研究人员的短缺和高流动率 由于制度和环境支持不足(3)；不愿放弃传统 以部门为中心的研究和培训模式；缺乏对博士科学家的有效教育 人类健康和疾病的生理学和病理生理学 (4);以及提供临床和实验台方面的差距 科学家拥有在当前研究环境中取得成功所需的工具，包括在 跨学科团队。在本节中，我们针对这些可能的障碍提出解决方案，并提供 可实现并可评估的实施计划。 我们 CTSA 应用程序这一关键组件的总体目标是创建下一代临床 代表多个学科的研究人员将成为边界跨越者，能够传播新思想并 将不同学科的实验室和研究人员联系起来。 西北大学几十年来一直致力于促进跨学科研究。它提供了激励措施 包括教师职位和研究经费，以打破学科之间的界限和障碍，以及 将生命科学和工程学科的研究生培养项目合并为4个综合项目 跨校园地点的项目。我们建议以已经成功的计划为基础 通过建立临床中心进行跨学科研究教育、培训和职业发展 研究教育（CCRE）。该中心将协调和加强现有的临床和转化 研究教育、培训和职业发展活动；创建新课程、研讨会和项目 并将其与现有活动相结合；通过包括博士前人员来扩大我们项目的候选人库 实习生和基础科学家；使用与过去不同的方式对候选人进行教育/培训 扩大课程设置和研讨会，建立跨学科团队，并培养 学员使用精心挑选的导师和新的监督程序，包括标准化的跟踪工具。 该中心还将为临床研究和监管人员以及社区提供新的机会 调查人员。该中心及其关键项目将由充满活力且经验丰富的领导团队领导。

项目成果

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.

• DOI: 10.1038/nm.3995
• 发表时间: 2015-12
• 期刊: Nature medicine
• 影响因子: 82.9
• 作者: Wen QJ;Yang Q;Goldenson B;Malinge S;Lasho T;Schneider RK;Breyfogle LJ;Schultz R;Gilles L;Koppikar P;Abdel-Wahab O;Pardanani A;Stein B;Gurbuxani S;Mullally A;Levine RL;Tefferi A;Crispino JD
• 通讯作者: Crispino JD

Fetal overnutrition and offspring insulin resistance and β-cell function: the Exploring Perinatal Outcomes among Children (EPOCH) study.

• DOI: 10.1111/dme.13417
• 发表时间: 2017-10
• 期刊: Diabetic medicine : a journal of the British Diabetic Association
• 作者: Sauder KA;Hockett CW;Ringham BM;Glueck DH;Dabelea D
• 通讯作者: Dabelea D