A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCI
一种用于评估和启用 SCI 后备用脊髓运动功能的治疗诊断工具
基本信息
- 批准号:8648234
- 负责人:
- 金额:$ 34.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-20 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAge-YearsAlgorithmsAmericanAnkleBypassCaringCervicalCervical spinal cord injuryChestChronicClinicClinicalClinical TrialsDataDevicesDiagnosisDiagnosticElectric StimulationElectrodesEnrollmentEvaluationFelis catusFinancial costGoalsHip region structureHumanImplantImplanted ElectrodesIndividualInjuryInterventionJointsKneeLegLifeLimb structureLower ExtremityLumbar spinal cord structureMachine LearningMeasurementMedicalModalityMotorMovementNervous System PhysiologyNeurologicNeurostimulation procedures of spinal cord tissueOutpatientsPainlessParalysedParaplegiaPatientsPharmaceutical PreparationsPhasePhysiologicalProductivityProtocols documentationRattusRecoveryResidual stateSiteSkinSpeedSpinalSpinal CordSpinal Cord PartSpinal InjuriesSpinal cord injurySpinal cord injury patientsStrokeSurfaceTechniquesTechnologyTestingTherapeuticThoracic spinal cord structureTimeToesTrainingTranscutaneous Electric Nerve StimulationTranslatingUpper ExtremityWeight-Bearing statedesignhuman subjecthuman subject protectionimplantationimprovedimproved functioninginjuredlife time costmeetingsmotor controlmotor function improvementneural circuitneuroregulationprototypepublic health relevanceresponsetheranosticstooltranscutaneous stimulation
项目摘要
A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCI
NeuroEnabling Technologies, Inc.
RESEARCH & RELATED Other Project Information
7. PROJECT SUMMARY
Of the approximately 10 million people in the US living with paralysis, 15,000 are the result of spinal cord injury each
year. The first year of care can range from $322,000-$986,000, with lifetime costs of $1.4-4M for someone injured at 25
years of age. In addition to potentially devastating sensorimotor disturbances, there is a huge financial cost, estimated to
be $13.55B in medical care, therapy, and lost productivity nationwide. Until very recently, the recovery from spinal cord
injury (SCI) was bleak, with little hope of restoring motor function. To address this we have demonstrated that the
physiological state of the spinal circuitry of rats and cats can be modulated with epidural stimulation to generate voluntary
limb motor function over a range of speeds, loads, and directions, a finding we have extended to humans. Three years
post-injury, a motor complete spinal cord injured human subject was implanted with an epidural electrode array over the
lumbosacral spinal cord. In less than one month after implantation, the subject could stand independently, and after 7
months of daily epidural stimulation and motor training, voluntary control of both legs was evident in the presence of
epidural stimulation, whereas complete paralysis remained in absence of epidural stimulation. We will advance these
discoveries with the use of non-invasive stimulation of the lumbosacral cord to improve lower limb function following
SCI. Central to this proposal is our discovery of a painless electrical multi-channel (stimulation of multiple parts of the
spinal cord) theranostic tool that can be applied to the surface of the skin, termed transcutaneous spinal cord electrical
stimulation (TESCS), bypassing the need for a surgically-implanted electrode array. In the first phase of this proposal we
will demonstrate proof-of-principle that stimulation of the lumbosacral spinal cord can assess spared spinal motor function
by: 1) Testing responses to transcutaneous electrical stimulation in subjects with spinal cord injury; and 2) defining the
operational parameters of electrical stimulation that that are most effective using a machine-learning protocol, and 3)
produce a multi-channel commercial prototype. This commercial product will undergo testing similar to the proof-of-
principle device. This device will then be tested in subjects with cervicothoracic spinal cord injury and evaluated with a
machine-learning protocol. This Phase I proposal will deliver a device that can painlessly and non-invasively aid in the
assessment and recovery of SCI by delivering a specific electrical stimulation paradigm to the lumbosacral cord that
improves use of the lower limbs.
一种评估和激活脊髓损伤后脊髓运动功能的治疗工具
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
REGGIE EDGERTON其他文献
REGGIE EDGERTON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('REGGIE EDGERTON', 18)}}的其他基金
Transformation of Paraplegic Paralysis to Overground Stepping in Humans
人类截瘫向地上行走的转变
- 批准号:
10025186 - 财政年份:2019
- 资助金额:
$ 34.62万 - 项目类别:
Transformation of Paraplegic Paralysis to Overground Stepping in Humans
人类截瘫向地上行走的转变
- 批准号:
9524130 - 财政年份:2019
- 资助金额:
$ 34.62万 - 项目类别:
Transformation of Paraplegic Paralysis to Overground Stepping in Humans
人类截瘫向地上行走的转变
- 批准号:
10241521 - 财政年份:2019
- 资助金额:
$ 34.62万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
8690845 - 财政年份:2013
- 资助金额:
$ 34.62万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
8507061 - 财政年份:2013
- 资助金额:
$ 34.62万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
8889256 - 财政年份:2013
- 资助金额:
$ 34.62万 - 项目类别:
A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCI
一种用于评估和启用 SCI 后备用脊髓运动功能的治疗诊断工具
- 批准号:
8735147 - 财政年份:2013
- 资助金额:
$ 34.62万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
9147671 - 财政年份:2013
- 资助金额:
$ 34.62万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
9358722 - 财政年份:2013
- 资助金额:
$ 34.62万 - 项目类别:
Activity-dependent functional regeneration after SCI and OEC transplantation
SCI 和 OEC 移植后活动依赖性功能再生
- 批准号:
8869049 - 财政年份:2012
- 资助金额:
$ 34.62万 - 项目类别:
相似海外基金
PREDICTING CARIES RISK IN UNDERSERVED CHILDREN, FROM TODDLERS TO THE SCHOOL-AGE YEARS, IN PRIMARY HEALTHCARE SETTINGS
预测初级医疗保健机构中从幼儿到学龄儿童的龋齿风险
- 批准号:
10361268 - 财政年份:2021
- 资助金额:
$ 34.62万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
9751077 - 财政年份:2011
- 资助金额:
$ 34.62万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
10457019 - 财政年份:2011
- 资助金额:
$ 34.62万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
9976990 - 财政年份:2011
- 资助金额:
$ 34.62万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
10213006 - 财政年份:2011
- 资助金额:
$ 34.62万 - 项目类别:














{{item.name}}会员




