Transformation of Paraplegic Paralysis to Overground Stepping in Humans
人类截瘫向地上行走的转变
基本信息
- 批准号:10241521
- 负责人:
- 金额:$ 54.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-30 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgonistAnkleAwarenessBody WeightBuspironeChronicClinicCommunitiesCutaneousDevelopmentDevicesDiagnosisElectrodesFamily CaregiverForce of GravityGenerationsGoalsHealthHealth Care CostsHip region structureHumanIndividualInjuryInterventionKneeLeadLesionLocomotionLower ExtremityMediatingMotionMotorMotor ActivityMovementMusMusculoskeletal EquilibriumNeurostimulation procedures of spinal cord tissueOutcomePainlessParalysedParaplegiaPerformancePharmacologyProbabilityPropertyQuality of lifeRattusRecoveryRecovery of FunctionSensorySeriesSiteSpeedSpinalSpinal CordSpinal InjuriesSpinal cord injurySpinal cord injury patientsStep trainingTechnologyTrainingVolitionWalkersWeight-Bearing stateconnectomecosteffectiveness evaluationexoskeletonexoskeleton deviceexperienceexperimental studyimprovedinsightlimb movementmotor controlmotor function improvementmotor function recoveryneuroregulationnovelrelative effectivenessrobot assistancerobotic devicetechnology developmenttooltreadmill
项目摘要
Project Summary
It is becoming increasingly evident that the spinal circuitries below a paralyzing injury have a functional potential
that far exceeds what has been thought to be possible. From recent studies in mice and rats with motor complete
paralysis we know that the lumbosacral spinal cord can be neuromodulated electrically (eEmc) and
pharmacologically (fEmc) to enable motor control, including full weight-bearing stepping. The main goal of the
project is the development of noninvasive multiple neuromodulatory strategies to facilitate full weight bearing
overground stepping in paralyzed subjects. Recently we demonstrated that four chronic, completely paralyzed
individuals regained the ability to stand independently and the ability to voluntarily flex the hip, knee, and ankle
when being stimulated epidurally. We propose to accomplish similar outcomes using a novel noninvasive
multi-site spinal cord stimulation strategy in concert with pharmacological modulation with stand and step
training to neuromodulate the lumbosacral circuitry so that completely paralyzed individuals can regain some
locomotor function as well as voluntary movements. We propose to develop these strategies further by
combining these interventions with an exoskeleton technology so that individuals with complete paralysis
can regain significant levels of community mobility. We will determine the effectiveness of noninvasive spinal
stimulation and administration of buspirone (a monoaminergic agonist) treatment for facilitating of locomotor
activity in the gravity-neutral apparatus, body weight supported stepping on a treadmill, and stepping in the EKSO
robotic device to achieve full weight bearing stepping in paralyzed subjects in rolling walker. It is anticipated that
the early stages of development of this technology could be available within the clinic to improve motor function
within a matter of a few years. These interventions have the potential to improve health, and can impact the
quality of life and, in many cases, can likely to lead to reduced health costs and a lower burden not only to the
paralyzed individuals, but also to their families and caregivers.
项目概要
越来越明显的是,瘫痪损伤下方的脊髓回路具有功能潜力
这远远超出了人们的想象。根据最近对具有运动功能的小鼠和大鼠的研究
我们知道腰骶脊髓可以进行电神经调节(eEmc)并且
药理学(fEmc)以实现运动控制,包括完全负重步进。该组织的主要目标是
该项目是开发非侵入性多重神经调节策略,以促进完全负重
瘫痪受试者的地面行走。最近我们证明了四种慢性、完全瘫痪的患者
个体重新获得独立站立的能力以及自愿弯曲臀部、膝盖和脚踝的能力
当受到硬膜外刺激时。我们建议使用新型非侵入性方法来实现类似的结果
多部位脊髓刺激策略与站立和步骤的药理调节相结合
进行神经调节腰骶回路的训练,以便完全瘫痪的人可以恢复一些能力
运动功能以及随意运动。我们建议通过以下方式进一步制定这些战略:
将这些干预措施与外骨骼技术相结合,使完全瘫痪的人
可以重新获得显着水平的社区流动性。我们将确定无创脊柱治疗的有效性
刺激和给予丁螺环酮(一种单胺能激动剂)治疗以促进运动
在重力中性装置中的活动、在跑步机上支撑体重的踩踏以及在 EKSO 中的踩踏
机器人装置可让瘫痪受试者在滚动助行器中实现完全承重行走。预计
该技术开发的早期阶段可在诊所内使用,以改善运动功能
几年之内。这些干预措施有可能改善健康,并可能影响
生活质量,并且在许多情况下,可能不仅会降低人们的健康成本和负担
瘫痪者,也包括他们的家人和护理人员。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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REGGIE EDGERTON其他文献
REGGIE EDGERTON的其他文献
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{{ truncateString('REGGIE EDGERTON', 18)}}的其他基金
Transformation of Paraplegic Paralysis to Overground Stepping in Humans
人类截瘫向地上行走的转变
- 批准号:
10025186 - 财政年份:2019
- 资助金额:
$ 54.87万 - 项目类别:
Transformation of Paraplegic Paralysis to Overground Stepping in Humans
人类截瘫向地上行走的转变
- 批准号:
9524130 - 财政年份:2019
- 资助金额:
$ 54.87万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
8690845 - 财政年份:2013
- 资助金额:
$ 54.87万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
8507061 - 财政年份:2013
- 资助金额:
$ 54.87万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
8889256 - 财政年份:2013
- 资助金额:
$ 54.87万 - 项目类别:
A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCI
一种用于评估和启用 SCI 后备用脊髓运动功能的治疗诊断工具
- 批准号:
8648234 - 财政年份:2013
- 资助金额:
$ 54.87万 - 项目类别:
A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCI
一种用于评估和启用 SCI 后备用脊髓运动功能的治疗诊断工具
- 批准号:
8735147 - 财政年份:2013
- 资助金额:
$ 54.87万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
9147671 - 财政年份:2013
- 资助金额:
$ 54.87万 - 项目类别:
Enabling forelimb function with agonist drug and epidural stimulation in SCI
使用激动剂药物和硬膜外刺激在 SCI 中启用前肢功能
- 批准号:
9358722 - 财政年份:2013
- 资助金额:
$ 54.87万 - 项目类别:
Activity-dependent functional regeneration after SCI and OEC transplantation
SCI 和 OEC 移植后活动依赖性功能再生
- 批准号:
8869049 - 财政年份:2012
- 资助金额:
$ 54.87万 - 项目类别:
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