Dexterous Robot-assisted trans-urethral Bladder Resection

灵巧机器人辅助经尿道膀胱切除术

基本信息

  • 批准号:
    8582906
  • 负责人:
  • 金额:
    $ 21.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-07-01 至 2015-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Transurethral resection of bladder tumor (TURBT) and pathological staging are both standard surgical therapies for non-muscle invasive bladder cancer and integral parts of the diagnostic evaluation and progression monitoring of all bladder tumors. TURBT is currently performed using straight resectoscopes and laser/cautery loops. Outcomes of TURBT are highly dependent on the experience and technical ability of the urologic surgeon and the location of the tumor. Anterior tumors are especially tricky to accurately resect due to the inability of straight surgical tools to curve up from the point of enty to the bladder. Surgeons currently rely on public pressure and resectoscope tilt to reach the frontal aspects of the bladder. However this technique has limited success in obese patients due to thick fat layer. Further, inadequate surveillance and tumor staging have been associated with misdiagnosed tumors and with a high recurrence rate. In addition, due to tool limitations, resection of tumors is carried out in a piece-meal fashion. This approach is hypothesized to possibly contribute to seeding new cancer locations and is counter indicative to the standard surgical practice of using en-block resection of tumors. Surgeons cannot validate this hypothesis due to lack of tooling that enables en-block resection. The short term goals of this Exploratory Bioengineering Research Grant (EBRG) focus on developing and evaluating new robots and tele-manipulation algorithms for improving dexterity, accuracy, and reliability of bladder surveillance and resection. The specific aims of this research are: 1. Design a rapidly deployable sensory and surgical intervention telemanipulation slave for transurethral bladder resection and surveillance, 2. Integrate this surgical slave into a telemanipulation system with high level telemanipulation assistive algorithms, 3. Evaluate this integrated system for transurethral bladder resection. Fulfillment of these specific aims will shed light on the potentia of robot-assisted bladder resection for improving quality and accuracy of bladder resection and the possibility of using this new technology to enable en-block resection. The long term goal of this EBRG is to provide patients with the benefits of a more accurate alternative to bladder resection and surveillance that in turn is expected to reduce misdiagnosis rates, minimize need for re-resection, and improve prognosis. This long term goal is in accordance with the mission of the National Health Institute since it focuses on improving patient outcome, reducing morbidity, and providing new tools for biomedical research. Successful completion of this proposed research has an expected broader impact of providing surgical technologies relevant for general trans-luminal surgery, trans-gastric, trans-uterine surgery, and trans-anal surgery.
描述(申请人提供):经尿道膀胱肿瘤切除术(Transurethral resection of膀胱tumor, turt)和病理分期是非肌性浸润性膀胱癌的标准手术治疗方法,也是所有膀胱肿瘤诊断评估和进展监测的重要组成部分。TURBT目前使用直切镜和激光/烧灼环进行。turt的结果高度依赖于泌尿外科医生的经验和技术能力以及肿瘤的位置。由于直的手术工具无法从膀胱点向上弯曲,前部肿瘤尤其难以准确切除。外科医生目前依靠公众压力和切除镜的倾斜来达到膀胱的前部。然而,由于肥胖患者脂肪层较厚,该技术的成功率有限。此外,不充分的监测和肿瘤分期与肿瘤的误诊和高复发率有关。此外,由于工具的限制,肿瘤切除以一顿一顿的方式进行。这种方法被推测可能有助于播种新的癌症位置,并且与使用肿瘤整体切除的标准外科实践相反。由于缺乏能够进行全块切除的工具,外科医生无法验证这一假设。这项探索性生物工程研究基金(EBRG)的短期目标是开发和评估新的机器人和远程操作算法,以提高膀胱监测和切除的灵活性、准确性和可靠性。本研究的具体目的是:1.研究方法:设计一种可快速展开的经尿道膀胱切除术及手术干预遥控控制系统。2 .将该手术从机集成到具有高级遥控辅助算法的遥控操作系统中。评估该综合系统在经尿道膀胱切除术中的应用。这些具体目标的实现将揭示机器人辅助膀胱切除术的潜力,以提高膀胱切除术的质量和准确性,以及使用这种新技术实现全块切除的可能性。EBRG的长期目标是为患者提供更准确的膀胱切除术和监测替代方案,从而减少误诊率,减少再次切除的需要,并改善预后。这一长期目标符合国家卫生研究所的使命,因为它的重点是改善病人的治疗结果,降低发病率,并为生物医学研究提供新的工具。本研究的成功完成有望为一般经腔手术、经胃手术、经子宫手术和经肛门手术提供更广泛的外科技术。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(1)

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Nabil Simaan其他文献

Nabil Simaan的其他文献

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{{ truncateString('Nabil Simaan', 18)}}的其他基金

Dexterous Robot-assisted trans-urethral Bladder Resection
灵巧机器人辅助经尿道膀胱切除术
  • 批准号:
    8688048
  • 财政年份:
    2013
  • 资助金额:
    $ 21.82万
  • 项目类别:
Image Guided In Vivo Tooling Platform for Minimal Access Surgery
用于微创手术的图像引导体内工具平台
  • 批准号:
    7478030
  • 财政年份:
    2007
  • 资助金额:
    $ 21.82万
  • 项目类别:
Image Guided In Vivo Tooling Platform for Minimal Access Surgery
用于微创手术的图像引导体内工具平台
  • 批准号:
    8200695
  • 财政年份:
    2007
  • 资助金额:
    $ 21.82万
  • 项目类别:
Image Guided In Vivo Tooling Platform for Minimal Access Surgery
用于微创手术的图像引导体内工具平台
  • 批准号:
    7664282
  • 财政年份:
    2007
  • 资助金额:
    $ 21.82万
  • 项目类别:

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