Guiding angiogenesis

引导血管生成

• 批准号: 8512597
• 负责人: Min Zhao
• 金额: $ 23.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8512597
• 关键词: 1-Phosphatidylinositol 3-Kinase; 3-Dimensional; Adverse effects; Angiogenesis Pathway; Angiogenic Factor; Apoptosis; Arthritis; Behavior; Biomedical Research; Blood Vessels; Cathodes; Cell Mobility; Cell Survival; Cells; Charge; Chronic; Cues; Disease; Electric Stimulation; Endothelial Cells; Engineering; Goals; Growth; Human body; Image; In Situ; Ischemia; Malignant Neoplasms; Mediating; Membrane; Monitor; Necrosis; Outcome; Pathologic Processes; Phagocytosis; Phosphatidylinositol 4,5-Diphosphate; Reporting; Role; Side; Signal Pathway; Signal Transduction; Staining method; Stains; Techniques; Testing; Tissues; Vascular Endothelial Growth Factors; angiogenesis; cell behavior; cell motility; chorioallantoic membrane; electric field; membrane model; migration; novel; operation; public health relevance; response; stem; time use

DESCRIPTION (provided by applicant): Directing angiogenesis is one of the overarching goals of biomedical research. Establishment of effective approaches to modulate angiogenesis will impact significantly treatment of many important diseases involving abnormal angiogenesis. We have uncovered a novel cue to direct endothelial behaviors and blood vessel growth - namely small direct current electric fields. Our long-term goal is to elucidate the role of electri signaling in regulating angiogenesis and to develop effective approaches to control angiogenesis. In this proposal, we specifically focus on establishment of stimulation strategies that are effective in guiding angiogenesis while safe with no or minimal harmful effects on cells and tissues.

描述（由申请人提供）：指导血管生成是生物医学研究的首要目标之一。建立有效的调控血管生成的方法将对许多涉及异常血管生成的重要疾病的治疗产生重大影响。我们已经发现了一种新的线索，直接内皮细胞的行为和血管生长-即小直流电场。我们的长期目标是阐明电信号在调节血管生成中的作用，并开发有效的方法来控制血管生成。在该提案中，我们特别关注建立有效引导血管生成的刺激策略，同时安全，对细胞和组织没有或只有最小的有害影响。