Guiding angiogenesis

描述（由申请人提供）：指导血管生成是生物医学研究的首要目标之一。建立有效的调节血管生成的方法将对许多涉及血管生成异常的重要疾病的治疗产生重大影响。我们发现了一个新的线索，直接内皮行为和血管生长-即小的直流电场。我们的长期目标是阐明电信号在调节血管生成中的作用，并开发有效的方法来控制血管生成。在本提案中，我们特别关注建立有效指导血管生成的刺激策略，同时安全，对细胞和组织没有或最小的有害影响。

DESCRIPTION (provided by applicant): Directing angiogenesis is one of the overarching goals of biomedical research. Establishment of effective approaches to modulate angiogenesis will impact significantly treatment of many important diseases involving abnormal angiogenesis. We have uncovered a novel cue to direct endothelial behaviors and blood vessel growth - namely small direct current electric fields. Our long-term goal is to elucidate the role of electri signaling in regulating angiogenesis and to develop effective approaches to control angiogenesis. In this proposal, we specifically focus on establishment of stimulation strategies that are effective in guiding angiogenesis while safe with no or minimal harmful effects on cells and tissues.