Guiding angiogenesis
Guiding angiogenesis
批准号:
8641356
负责人:
Min Zhao
金额:
$18.67万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-06-01 至 2016-05-31
关键词:
1-Phosphatidylinositol 3-Kinase3-DimensionalAdverse effectsAngiogenesis PathwayAngiogenic FactorApoptosisArthritisBehaviorBiomedical ResearchBlood VesselsCathodesCell MobilityCell SurvivalCellsChargeChronicCuesDiseaseElectric StimulationEndothelial CellsEngineeringGoalsGrowthHuman bodyImageIn SituIschemiaMalignant NeoplasmsMediatingMembraneMonitorNecrosisOutcomePathologic ProcessesPhagocytosisPhosphatidylinositol 4,5-DiphosphateReportingRoleSideSignal PathwaySignal TransductionStaining methodStainsTechniquesTestingTissuesVascular Endothelial Growth Factorsangiogenesiscell behaviorcell motilitychorioallantoic membraneelectric fieldmembrane modelmigrationnoveloperationpublic health relevanceresponsestemtime use
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Directing angiogenesis is one of the overarching goals of biomedical research. Establishment of effective approaches to modulate angiogenesis will impact significantly treatment of many important diseases involving abnormal angiogenesis. We have uncovered a novel cue to direct endothelial behaviors and blood vessel growth - namely small direct current electric fields. Our long-term goal is to elucidate the role of electri signaling in regulating angiogenesis and to develop effective approaches to control angiogenesis. In this proposal, we specifically focus on establishment of stimulation strategies that are effective in guiding angiogenesis while safe with no or minimal harmful effects on cells and tissues.
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Guiding angiogenesis
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批准号:8512597
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项目类别:
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资助金额:$23.1万
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财政年份:2013
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负责人:Min Zhao
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依托单位:
Ion Channels and Pumps: The Machinery of Electric Signaling at Corneal Wounds
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批准号:8277701
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项目类别:
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资助金额:$5.0万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical Signals
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批准号:9892012
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项目类别:
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资助金额:$39.25万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Ion Channels and Pumps: The Machinery of Electric Signaling at Corneal Wounds
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批准号:7994780
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项目类别:
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资助金额:$36.77万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical Signals
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批准号:10133074
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项目类别:
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资助金额:$38.07万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical Signals
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批准号:10374031
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项目类别:
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资助金额:$38.07万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Ion Channels and Pumps: The Machinery of Electric Signaling at Corneal Wounds
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批准号:8197507
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项目类别:
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资助金额:$36.89万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Molecular generators at corneal wounds produce and regulate the wound electrical signals
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批准号:8819078
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项目类别:
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资助金额:$39.04万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical Signals
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批准号:9928754
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项目类别:
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资助金额:$10.88万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical Signals
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批准号:10601001
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项目类别:
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资助金额:$39.25万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Molecular generators at corneal wounds produce and regulate the wound electrical signals
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批准号:9039611
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项目类别:
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资助金额:$39.21万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Ion Channels and Pumps: The Machinery of Electric Signaling at Corneal Wounds
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批准号:7784815
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项目类别:
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资助金额:$38.25万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
Ion Channels and Pumps: The Machinery of Electric Signaling at Corneal Wounds
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批准号:8389547
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项目类别:
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资助金额:$35.11万
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财政年份:2009
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负责人:Min Zhao
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依托单位:
海外基金