Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast

项目摘要/摘要 该项目概述了用于新型图像对比度的生物工程技术进展 超极化碳-13核磁共振的新兴领域。这一领域的初步研究是 非常有前景，特别是在癌症应用和第一次前列腺人体试验中 癌症患者将在6个月内在加州大学旧金山分校就诊。这条“独立之路” 获奖申请包括候选人过渡的指导职业发展计划， Peder Larson博士成为一名独立调查员，以及随之而来的研究计划 介绍了超极化碳-13的拟议技术进展。 候选人Peder Larson博士目前是加州大学旧金山分校的博士后学者，致力于 超极化碳-13磁共振成像技术进展。他的毕业课程是电工系 他专注于改进半固体组织的磁共振成像，这种组织是看不见的 在常规核磁共振中。指导和职业发展计划将补充他的 有工程背景，对超极化物理和化学有很好的了解， 生物系统和生物化学、临床前研究和跨学科合作，以 促进向独立生物工程调查员的过渡。他的目标是成为 生物工程或放射学的教员，在那里他可以研究技术生物医学 具有潜在临床应用的影像发展。 超极化碳-13核磁共振需要特殊的方法，因为与传统核磁共振不同， 信号迅速衰减，无法恢复。该项目提出了快速高效的 提供局部灌注、摄取和速率的动态代谢成像方法 这些信息在目前的技术中是不可用的。与之形成对比的新来源 超极化碳-13也被提出，包括一种区分流动的方法 来自组织内的代谢物和开发专门的技术 碳13毒剂。对正常动物的临床前研究将用于研究新的 成像方法。这将促进方法从开发到未来的转换 临床应用。 ) )

Project Summary/Abstract This project outlines technical bioengineering developments for new types of image contrast in the emerging field of hyperpolarized carbon-13 MRI. Preliminary research in this field is extremely promising, particularly for cancer applications, and the first human trials in prostate cancer patients are slated to occur at UCSF within 6 months. This "Pathway to Independence" award application includes a mentored career development plan for transition of the candidate, Dr. Peder Larson, into an independent investigator, as well an accompanying research plan describing the proposed technical developments for hyperpolarized carbon-13 MR. The candidate, Dr. Peder Larson, is currently a Postdoctoral Scholar at UCSF working on technical developments for hyperpolarized carbon-13 MRI. His graduate work was in Electrical Engineering at Stanford and focused on improving MRI of semi-solid tissues, which are invisible in conventional MRI. The mentoring and career development plan will supplement his engineering background with valuable exposure to hyperpolarization physics and chemistry, biological systems and biochemistry, pre-clinical research, and inter-disciplinary collaboration to facilitate the transition to an independent bioengineering investigator. His goals are to become a faculty member in bioengineering or radiology where he can research technical biomedical imaging developments with potential clinical applications. Hyperpolarized carbon-13 MRI requires specialized methods because, unlike conventional MRI, the signal decays rapidly and is unrecoverable. This project proposes rapid and efficient methods for dynamic metabolic imaging to provide localized perfusion, uptake and rate information that are unavailable in current techniques. New sources of contrast with hyperpolarized carbon-13 are also proposed, including a method to distinguish flowing metabolites from those within tissues and development of specialized techniques for multiple carbon-13 agents. Preclinical studies in normal animals will be used for investigation of the new imaging methods. This will facilitate the translation of the methods from development to future clinical application. ) )