Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast

项目总结/摘要 该项目概述了生物工程技术的发展，为新类型的图像对比度， 超极化碳-13 MRI的新兴领域。该领域的初步研究是 非常有前途，特别是对于癌症的应用，以及前列腺的首次人体试验， 癌症患者将在6个月内出现在UCSF。这条“独立之路” 奖项申请包括候选人过渡的指导性职业发展计划， 博士佩德·拉尔森，成为一名独立调查员，以及一个附带的研究计划， 描述了超极化碳-13 MR的拟议技术发展。 候选人Peder Larson博士目前是加州大学旧金山分校的博士后学者， 超极化碳-13核磁共振成像的技术发展。他的研究生工作是在电气 工程在斯坦福大学，并专注于改善磁共振成像的半固体组织，这是不可见的 在常规MRI中。指导和职业发展计划将补充他的 工程背景，对超极化物理学和化学有很好的了解， 生物系统和生物化学，临床前研究和跨学科合作， 促进过渡到一个独立的生物工程研究者。他的目标是成为 生物工程或放射学的教员，他可以研究技术生物医学 具有潜在临床应用的成像发展。 超极化碳-13 MRI需要专门的方法，因为与常规MRI不同， 信号迅速衰减并且不可恢复。该项目提出了快速、高效 提供局部灌注、摄取和速率的动态代谢成像方法 这些信息在当前技术中不可用。对比的新来源 还提出了超极化碳-13，包括区分流动的方法， 从组织内的代谢物和发展的专门技术， 碳13物质正常动物的临床前研究将用于研究新的 成像方法这将有助于将发展中的方法转化为未来的方法 临床应用 ) )

Project Summary/Abstract This project outlines technical bioengineering developments for new types of image contrast in the emerging field of hyperpolarized carbon-13 MRI. Preliminary research in this field is extremely promising, particularly for cancer applications, and the first human trials in prostate cancer patients are slated to occur at UCSF within 6 months. This "Pathway to Independence" award application includes a mentored career development plan for transition of the candidate, Dr. Peder Larson, into an independent investigator, as well an accompanying research plan describing the proposed technical developments for hyperpolarized carbon-13 MR. The candidate, Dr. Peder Larson, is currently a Postdoctoral Scholar at UCSF working on technical developments for hyperpolarized carbon-13 MRI. His graduate work was in Electrical Engineering at Stanford and focused on improving MRI of semi-solid tissues, which are invisible in conventional MRI. The mentoring and career development plan will supplement his engineering background with valuable exposure to hyperpolarization physics and chemistry, biological systems and biochemistry, pre-clinical research, and inter-disciplinary collaboration to facilitate the transition to an independent bioengineering investigator. His goals are to become a faculty member in bioengineering or radiology where he can research technical biomedical imaging developments with potential clinical applications. Hyperpolarized carbon-13 MRI requires specialized methods because, unlike conventional MRI, the signal decays rapidly and is unrecoverable. This project proposes rapid and efficient methods for dynamic metabolic imaging to provide localized perfusion, uptake and rate information that are unavailable in current techniques. New sources of contrast with hyperpolarized carbon-13 are also proposed, including a method to distinguish flowing metabolites from those within tissues and development of specialized techniques for multiple carbon-13 agents. Preclinical studies in normal animals will be used for investigation of the new imaging methods. This will facilitate the translation of the methods from development to future clinical application. ) )