Center for Genomics and Healthcare Equality

描述(由申请人提供)：基因组研究正在迅速扩大我们对健康和疾病的基因贡献者的知识。这项研究将带来广泛的健康益处，包括预测疾病风险和指导药物使用的测试、创新疗法，以及更好地理解基因和环境因素对健康的相互作用。然而，不同的疾病和人群的具体受益将有所不同，受遗传和非遗传贡献者的性质以及治疗方案的可用性和安全性的影响。特定个人或群体受益的可能性也将受到社会、政治和经济因素的影响，如获得医疗保健的机会、遗传风险信息的含义以及特定干预措施的成本和可接受性。特别是，医疗服务不足和被边缘化的人群在从基因组健康应用中受益方面可能会遇到更大的障碍，基因组学有可能加剧现有的健康差距。在基因组学和医疗保健平等中心的这次更新申请中，我们将在现有工作的基础上开发提高基因组翻译好处的方法，并特别关注利用基因组技术来解决人口健康和健康差距问题。我们中心的具体目标是：(1)描述从基因组发现到健康益处的转化过程中的一系列挑战和机会，重点是为医疗服务不足的人群提供好处；(2)开发方法来建立和评估大学-社区和跨学科伙伴关系，包括确定共同点的审议过程和战略；(3)开发工具，以协助关于基因组健康应用的临床使用和补偿的决策；(4)提供培训机会，鼓励未被充分代表的少数族裔的研究人员参与中心的研究议程和其他ELSI研究；(5)促进合作伙伴关系，从而产生解决这些问题和相关问题的额外资助研究。

DESCRIPTION (provided by applicant): Genomic research is rapidly expanding our knowledge about the genetic contributors to health and disease. A broad range of health benefits will flow from this research, including tests to predict disease risk and guide drug use, innovative therapies, and improved understanding of the interactions between genetic and environmental contributors to health. How ever, the specific benefits will vary for different diseases and populations, influenced by the nature of the genetic and non-genetic contributors, and the availability and safety of therapeutic options. T he likelihood of benefit for a particular individual or group will also be influenced by social, political and economic factors such as access to health care, meaning attached to genetic risk information, and cost and acceptability of specific interventions. In particular, medically underserved and marginalized populations may experience greater barriers to receiving benefit from genomic health applications, with the potential for genomics to exacerbate existing health disparities. In this renewal application of the Center for Genomics and Healthcare Equality, we will build on our existing work to develop methods for enhancing the benefits of genomic translation, with particular attention to the use of genomic technology to address population health and health disparities. The specific aims of our center are to: (1) Characterize the range of challenges and opportunities in the translation process from genomic discovery to health benefit with an emphasis on targeting benefits for medically underserved populations; (2) Develop methods to build and evaluate university -community and interdisciplinary partnerships, including deliberative processes and strategies to identify common ground; (3) Develop tools to assist decision-making about the clinical use and reimbursement of genomic health applications; (4) Provide training opportunities to encourage the participation of researchers from underrepresented minorities in the Center's research agenda and other ELSI research; (5) Stimulate collaborative partnerships that result in additional funded research addressing these and related questions.