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1/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)

1/6 儿童/青少年焦虑多模式扩展长期研究 (CAMELS)

基本信息

批准号：
8530278
负责人：
ANNE MARIE ALBANO
金额：
$ 10.84万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8530278
关键词：
Academic Medical Centers Acute Address Adherence Adolescent Adverse effects Affect Alcohol or Other Drugs use Anxiety Anxiety Disorders Benchmarking Biometry Budgets California Child Childhood Chronic Clinic Clinical Clinical Research Cognition Cognitive Therapy Collaborations Communication Consensus Data Data Analyses Data Set Development Diagnosis Diagnostic Discipline Disease Distal Early treatment Enrollment Ethnic Origin Feeling suicidal Fright Generalized Anxiety Disorder Goals Grant Growth and Development function Guidelines Impairment Individual Institutes Intervention Interview Journals Lead Letters Light Longitudinal Studies Los Angeles Maintenance Manuscripts Measures Mediator of activation protein Medical Medicine Mental Depression Mental Health Mental Health Services Mental disorders Methods Modeling Monitor National Institute of Mental Health New England New York Newsletter Paper Parents Participant Pattern Persons Pharmaceutical Preparations Phase Physical Function Placebos Preparation Prevalence Prevention Preventive Procedures Protocols documentation Psychiatrist Psychologist Psychopathology Public Health Publications Publishing Random Allocation Randomized Records Recruitment Activity Relapse Relative (related person)Research Research Infrastructure Research Personnel Risk Role Rural Sampling Sampling Studies Selective Serotonin Reuptake Inhibitor Separation Anxiety Disorder Sertraline Services Severity of illness Site Social Phobia Structure Substance Use Disorder Symptoms Teleconferences Telephone Time Training Universities Voting Work Youth cost data management depressive symptoms effective intervention effective therapy experience follow-up functional outcomes human subject interest meetings member multi-site trial multidisciplinary operation pill prevent primary outcome psychologic psychosocial public health relevance quality assurance response service utilization social suicidal behavior symposium synergism teacher treatment effect treatment trial vigilance willingness

项目摘要

DESCRIPTION (provided by applicant): Anxiety disorders are the most common psychiatric illnesses in youth with prevalence rates averaging 5-20%. These disorders are associated with significant short- and long-term impairment in academic, familial, social, and psychological functioning. Although medication and cognitive-behavioral therapy (CBT) have been found to be effective in the short term, questions remain regarding the durability of treatment effects and the relative impact of intervention on long-term functioning. This competing continuation application (in response to PAR- 09-153) will continue the successful multi-site collaboration of the Child/Adolescent Anxiety Multi-modal Study (CAMS) group to conduct a 5-year follow-up of the sample of youth with anxiety disorders that participated in the CAMS trial. The six sites are: New York State Psychiatric Institute; Duke University Medical Center; Johns Hopkins University; Temple University; University of California at Los Angeles; and Western Psychiatric Institute and Clinic. The central questions of the proposed study, entitled the Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS), are to examine the long-term psychiatric, physical, and functional outcomes of youth with anxiety disorders who were randomized to one of four treatment conditions (i.e., CBT, sertraline [SRT], pill placebo, or combined CBT + SRT). CAMS succeeded in randomizing 488 children/adolescents. The CAMELS is critical in light of the need for additional information about the effects of successful treatment on the course of anxiety symptoms and their sequelae and the NIMH priority to understand the developmental trajectories of mental illness (US DHHS, 2008). CAMELS will enroll the largest sample of carefully characterized youth with anxiety disorders and will inform the field about: 1) the preventive effects of successful treatment (psychosocial; medication) on the development of later psychopathology, 2) treatment durability, 3) potential long-term adverse effects (e.g., from chronic use of medication), and 4) predictors of relapse or long-term maintenance. Findings will also be used to refine current treatments, shedding light on how existing interventions may need to be augmented or personalized to target specific distal psychopathology and/or functional outcomes for specific children.

描述（由申请人提供）：焦虑症是青少年最常见的精神疾病，患病率平均为5- 20%。这些疾病与学术、家庭、社会和心理功能的显著短期和长期损害有关。虽然药物和认知行为疗法（CBT）已被发现在短期内有效，但关于治疗效果的持久性和干预对长期功能的相对影响仍然存在问题。这一竞争性继续申请（响应PAR- 09-153）将继续儿童/青少年焦虑多模式研究（CAMS）组成功的多中心合作，对参加CAMS试验的焦虑症青年样本进行5年随访。这六个地点是：纽约州立精神病学研究所;杜克大学医学中心;约翰·霍普金斯大学;天普大学;加州大学洛杉矶分校;和西方精神病学研究所和诊所。这项名为“儿童/青少年焦虑多模式扩展长期研究”（CAMELS）的拟议研究的中心问题是检查患有焦虑症的青少年的长期精神、身体和功能结果，这些青少年被随机分配到四种治疗条件之一（即，CBT、舍曲林[SRT]、安慰剂药丸或CBT + SRT组合）。CAMS成功随机化了488名儿童/青少年。考虑到需要更多关于成功治疗对焦虑症状及其后遗症的影响的信息，以及NIMH优先考虑了解精神疾病的发展轨迹，CAMELS至关重要（美国卫生和公众服务部，2008年）。CAMELS将招募最大规模的经过仔细描述的焦虑症青少年样本，并将向该领域通报：1）成功治疗（心理社会;药物）对后期精神病理学发展的预防作用，2）治疗持久性，3）潜在的长期不良反应（例如，从长期使用药物），和4）复发或长期维持的预测因素。研究结果还将用于完善当前的治疗方法，阐明现有的干预措施可能需要如何增强或个性化，以针对特定儿童的特定远端精神病理学和/或功能结局。