Research Fellowship in Geriatric Mood Disorders

描述(由申请者提供)：这是老年情绪障碍T32韦尔-康奈尔研究奖学金项目的第五个竞争性申请，该项目提供多学科培训已有20年。从概念上讲，我们认为情绪障碍是异质性的，其病因来自遗传因素、衰老和疾病相关的生物变化、残疾和心理社会因素。在方法上，我们教授生物学评估技术以及纵向设计和临床驱动的干预措施，在患者、实践和社区层面。这种方法导致了在有巨大健康和心理健康需求的人群中进行转译研究。该计划的优势是：1)受训人员的学术记录；在过去10年中接受培训的17名研究员获得了22项奖学金，并合著了101篇论文(41篇第一作者)；2)在国家一级的研究培训方面的领导地位(NIMH夏季研究所和高级研究所的PI)；3)NIMH资助的翻译研究教员，范围包括分子遗传学、神经成像、临床药理学、干预开发和精神卫生服务研究；4)康奈尔ACISR的协调组织；5)五个试点项目计划；6)丰富的研究人群和实验室资源；7)可供研究员进行二次分析和生成假说的数据库；8)与老年医学、普通内科、临床流行病学和服务研究计划、公共卫生和医学伦理学的研究人员进行长期和有效的合作；以及9)领导8项多站点研究。该计划将由临床生物学(G.Alexopoulos)和卫生服务研究(M.Bruce)的资助研究人员指导，他们在研究培训方面有良好的记录，并由在分子遗传学、神经成像和治疗开发方面具有专业知识的执行委员会指导。我们要求每年支持2名学员，他们的个性化培训计划将由两名导师(例如，一名临床和一名基础研究员或一名服务和一名临床研究员)协调，以促进翻译研究。除了核心课程之外，我们还指导和支持学员进行他们自己的研究，准备有竞争力的资助申请，并发表基于数据的论文。

DESCRIPTION (provided by applicant): This is the fifth competing application of the T32 Weill-Cornell Research Fellowship Program in Geriatric Mood Disorders, which has been offering multidisciplinary training for 20 years. Conceptually, we view mood disorders as heterogeneous with etiological contributions from genetic factors, aging- and disease-related biological changes, disability, and psychosocial factors. Methodologically, we teach biological assessment techniques as well as longitudinal designs and clinically-driven interventions at the patient, the practice, and the community levels. This approach has led to translational studies in a population with great health and mental health needs. The Program's strengths are: 1) The academic record of its trainees; the 17 fellows trained of the past 10 years received 22 grants and coauthored 101 papers (41 first-authored); 2) Leadership in research training at a national level (PIs of the NIMH Summer Research Institute and the Advanced Research Institute); 3) NIMH- funded faculty in translational research ranging from molecular genetics, neuroimaging, clinical pharmacology, intervention development, and mental health services research; 4) Cohesive organization of the Cornell ACISR; 5) Five pilot project programs; 6) Rich study populations and laboratory resources; 7) Databases available for secondary analyses and hypothesis generation by the fellows; 8) Long and effective collaboration with investigators of Geriatric Medicine, General Internal Medicine, Clinical Epidemiology and Services Research Program, Public Health and Medical Ethics; and 9) Leadership in 8 multisite studies. The Program will be directed by funded investigators in clinical biology (G. Alexopoulos) and health services research (M. Bruce) with a strong record in research training and by an Executive Committee with expertise in molecular genetics, neuroimaging, and treatment development. We request support for 2 trainees per year, whose individualized training programs will be coordinated by two preceptors (e.g. one clinical and one basic investigator or one services and one clinical investigator) to facilitate translation research. Beyond a Core Curriculum, we guide and support our trainees in conducting their own research studies, in preparing competitive funding applications, and in publishing data-based papers.