Principal Research Core

主要研究核心（PRC）的使命是作为ACISR的概念架构师， 研究计划。为此，中国将促进临床，心理社会和生物学方面的研究 老年抑郁症治疗效果的预测因子和调节因子，并利用其研究结果 作为开发在患者和护理设置水平上个性化护理的干预措施的刺激因素。一 PRC的中心职能是促进设计，允许在社区进行干预试验， 在有效性证据允许的最快时间设置。 中国依赖于：1。具有长期研究规划经验和互补专业知识的研究者 临床生物学，社会系统，初级保健，家庭保健和康复研究，生物统计学， 具有长期合作历史的经济学，能够将他们的观点整合到有凝聚力的 假设; 2.一个组织，迅速翻译生物和心理社会的研究结果和临床 干预研究的经验; 3.独立支持项目的跟踪记录（10个由NIH资助 去年，基金会举办了8次; 4.调查员职业发展经验（目前为8名 NIMH K奖由ACISR支持）;和5。与韦斯特切斯特大学的研究合作伙伴关系 老年精神卫生联盟，其中包括县精神卫生部，县 老年人方案和服务部，基于社区的初级保健做法，康复 医院;家庭保健机构;和其他社会服务。 研究开发和协调的过程取决于中国管理团队的发展 将我们的专业知识和研究成果与社区投入结合起来， 老年人以及照顾他们的环境的优势和局限性。发展项目1、2 和3，试点1和2，和CNU研究倡议在本申请中提出了这一进程。 PRC与研究方法核心（RMC）密切合作;它向RMC提供刺激和数据 为它的方法研究，而它结合了RMC的创新设计的实质性 问题研究与业务核心的社区网络股和信息、通信和信息研究中心社区联合开展 作为合作伙伴，中国概念化并支持有可能为大量人提供护理的研究 我们社区的老年人，包括那些被传统临床研究忽视的人。

The Principal Research Core's (PRC) mission is to serve as the conceptual architect of the ACISR's research program. To this end, the PRC will promote studies on clinical, psychosocial, and biological predictors of outcomes and moderators of treatment response of geriatric depression and use their findings as a stimulus for developing interventions personalizing care at the patient and the care setting level. A central function of the PRC will be to promote designs that permit testing of interventions at community settings at the soonest possible time that evidence of efficacy permits. The PRC relies on: 1. Investigators with long experience in research planning and complementary expertise in clinical biology, social systems, primary care, home healthcare and rehabilitation studies, biostatistics, and economics with long history of collaboration and ability to integrate their perspectives into cohesive hypotheses; 2. an organization that rapidly translates biological and psychosocial findings and clinical experience into intervention studies; 3. a track record of independently supported projects (10 funded by NIH and 8 by Foundations in the past year); 4. experience in career development of investigators (currently 8 NIMH K Awards are supported by the ACISR); and 5. working research partnerships with the Westchester Geriatric Mental Health Coalition, which includes the County Department of Mental Health, the County Department of Senior Programs and Services, community based primary care practices, rehabilitation hospitals; home healthcare agencies; and other social services. The process of research development and coordination depends on the PRC Management Team developing initiatives that integrate our expertise and research findings with community input on the needs of depressed older adults and the strengths and limitations of the settings that care for them. Developmental Projects 1, 2 and 3, Pilot 1 and 2, and the CNU Research Initiatives presented in this application exemplify this process. The PRC works closely with the Research Methods Core (RMC); it provides to the RMC a stimulus and data for its methodological studies, while it incorporates the RMC innovations in the designs of substantive studies. Jointly with the Community Network Unit of the Operations Core and the ACISR community partners, the PRC conceptualizes and supports studies with the potential to bring care to large numbers elders of our community, inclusing those neglected by traditional clinical research.