Principal Research Core

首席研究核心(中国)的任务是作为ACISR的概念架构师 研究计划。为此，中华人民共和国将促进临床、心理学和生物学的研究。 老年抑郁症预后的预测因子和治疗反应的调节因子及其应用 作为开发干预措施的刺激，使患者和护理环境层面的护理个人化。一个 中华人民共和国的中心职能将是促进允许在社区测试干预措施的设计 在疗效证据允许的尽可能早的时间进行设置。 中华人民共和国依靠：1.具有长期研究规划经验和互补专业知识的调查人员 在临床生物学、社会制度、初级保健、家庭保健和康复研究、生物统计学和 有悠久的合作历史和将他们的观点整合为凝聚力的经济学 假说；2.一个快速翻译生物学和心理学研究结果和临床的组织 干预研究的经验；3.独立资助项目的记录(10个由美国国立卫生研究院资助 4.调查人员的职业发展经验(目前为8 NIMH K奖由ACISR支持)；以及5.与Westchester的工作研究伙伴关系 老年精神卫生联盟，其中包括县精神卫生厅、县 老年方案和服务部，以社区为基础的初级保健实践，康复 医院；家庭保健机构；以及其他社会服务。 研究开发和协调的过程依赖于中国管理团队的发展 将我们的专业知识和研究结果与社区对抑郁症需求的投入相结合的举措 老年人以及照顾他们的环境的优势和局限性。发展项目1、2 和3，试点1和2，以及本申请中提出的CNU研究倡议就是这一过程的例证。 中华人民共和国与研究方法核心(RMC)密切合作；它向RMC提供刺激和数据 在其方法论研究方面，虽然它将RMC的创新纳入了实质性的 学习。与业务核心的社区网络股和ACISR社区合作 合作伙伴，中华人民共和国概念化和支持有可能为大量患者带来护理的研究 我们社区的长辈，包括那些被传统临床研究忽视的人。

The Principal Research Core's (PRC) mission is to serve as the conceptual architect of the ACISR's research program. To this end, the PRC will promote studies on clinical, psychosocial, and biological predictors of outcomes and moderators of treatment response of geriatric depression and use their findings as a stimulus for developing interventions personalizing care at the patient and the care setting level. A central function of the PRC will be to promote designs that permit testing of interventions at community settings at the soonest possible time that evidence of efficacy permits. The PRC relies on: 1. Investigators with long experience in research planning and complementary expertise in clinical biology, social systems, primary care, home healthcare and rehabilitation studies, biostatistics, and economics with long history of collaboration and ability to integrate their perspectives into cohesive hypotheses; 2. an organization that rapidly translates biological and psychosocial findings and clinical experience into intervention studies; 3. a track record of independently supported projects (10 funded by NIH and 8 by Foundations in the past year); 4. experience in career development of investigators (currently 8 NIMH K Awards are supported by the ACISR); and 5. working research partnerships with the Westchester Geriatric Mental Health Coalition, which includes the County Department of Mental Health, the County Department of Senior Programs and Services, community based primary care practices, rehabilitation hospitals; home healthcare agencies; and other social services. The process of research development and coordination depends on the PRC Management Team developing initiatives that integrate our expertise and research findings with community input on the needs of depressed older adults and the strengths and limitations of the settings that care for them. Developmental Projects 1, 2 and 3, Pilot 1 and 2, and the CNU Research Initiatives presented in this application exemplify this process. The PRC works closely with the Research Methods Core (RMC); it provides to the RMC a stimulus and data for its methodological studies, while it incorporates the RMC innovations in the designs of substantive studies. Jointly with the Community Network Unit of the Operations Core and the ACISR community partners, the PRC conceptualizes and supports studies with the potential to bring care to large numbers elders of our community, inclusing those neglected by traditional clinical research.