Can Cortical Plasticity be Directed and Amplified Following Early Loss of Vision?
早期视力丧失后皮质可塑性可以被引导和增强吗?
基本信息
- 批准号:8421193
- 负责人:
- 金额:$ 37.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-01 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAnimal ModelAnimalsAreaAuditory systemAxonBehaviorBehavioralBilateralBirthBlindnessBrainCell DensityChildDevelopmentDidelphidaeEnhancersEnhancing LesionEnvironmentExhibitsEyeFetusFinancial compensationFrequenciesHumanIndividualInfantInjuryInterventionInvadedInvestigationKnowledgeLesionMammalsMediatingModalityMonodelphisMonodelphis DomesticaNeocortexNervous system structureNeuronsNewborn InfantPerinatalPlayPropertyRecoveryResearchRetinaRetinalRetinal Ganglion CellsRoleSensoryStagingStructureSystemTactileTechniquesTestingTextureThalamic structureTherapeuticTherapeutic InterventionTimeTranslatingVisualVisual AcuityVisual CortexVisual impairmentVisual system structurebehavior testblindbrain shapedensitydiencephalondriving behaviorextrastriate visual cortexin uteromultisensorynovelprematureprenatalpublic health relevancerelating to nervous systemresponsesensory discriminationsomatosensorysubventricular zonetherapy designvisual processvisual processing
项目摘要
DESCRIPTION (provided by applicant): A distinguishing feature of the mammalian neocortex is its remarkable ability to change over a lifetime, especially during early development. Thus, the
functional organization and connectivity of each individual's brain is tailored to the physical parameters of a specific environment, permitting behavior to be uniquely optimized for a given sensory milieu. Such plasticity plays an integral role in shaping the brains of normal humans as well those who suffer from severe visual impairments due to retinal abnormalities or cortical lesions that occur at various stages of development. This proposal will investigate the extent of cortical plasticity following experimentally induced manipulations to the visual system during development. Our first objective is to examine the alterations in sensory mediated behavior, as well as changes in the functional organization, connectivity and cellular composition of the neocortex that result from one of two induced neural insults: 1) loss of neocortex that would normally develop into visual cortex; 2) loss of visual input normally provided by the retina. The second objective is to determine if early, pervasive sensory enhancement can be used to direct the functional reorganization of the neocortex and optimize sensory mediated behavior. Manipulations will be made at one of three developmental milestones: 1) Before retinal ganglion cell axons enter the diencephalon and before thalamocortical afferents have reached the cortex. 2) Before eye opening, after thalamocortical afferents have innervated the neocortex, but before axonal pruning and the completion of cortical development. 3) Just after the eyes have opened, when retinofugal and thalamocortical development is established and the subventricular zone and all six cortical layers are present. These animals will be exposed to either a normal or to a tactilely (for bilateral enucleates) or visually (for cortical lesions) enhanced environment. Our animal model, the short-tailed opossum (Monodelphis domestica) is born prematurely, allowing ex-utero manipulations to the nervous system at developmental time points that would be in-utero in other mammals. After the animals have reached maturity we will use behavioral testing combined with electrophysiological and neuroanatomical techniques to examine sensory discrimination, the functional organization and neural response properties of re-organized cortex, cortical and thalamic connectivity, and the cellular composition including neuronal number and density of re-organized cortex. These studies, which are novel in their scope, provide an opportunity to translate detailed knowledge gained at the cellular and systems level to produce significant therapeutic interventions designed to direct multisensory plasticity, and optimize sensory mediated behavior following loss of vision.
描述(由申请人提供):哺乳动物新皮层的一个显著特征是其在一生中显著的变化能力,特别是在早期发育期间。因此,
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LEAH ANN KRUBITZER其他文献
LEAH ANN KRUBITZER的其他文献
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{{ truncateString('LEAH ANN KRUBITZER', 18)}}的其他基金
Cross modal plasticity following loss of vision at different developmental stages: Cortical function, connections and compensatory behavior
不同发育阶段视力丧失后的跨模式可塑性:皮质功能、连接和补偿行为
- 批准号:
10504252 - 财政年份:2022
- 资助金额:
$ 37.59万 - 项目类别:
Cross modal plasticity following loss of vision at different developmental stages: Cortical function, connections and compensatory behavior
不同发育阶段视力丧失后的跨模式可塑性:皮质功能、连接和补偿行为
- 批准号:
10666604 - 财政年份:2022
- 资助金额:
$ 37.59万 - 项目类别:
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
环境对大鼠感觉运动皮层的影响:功能组织、连接和行为
- 批准号:
10553708 - 财政年份:2021
- 资助金额:
$ 37.59万 - 项目类别:
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
环境对大鼠感觉运动皮层的影响:功能组织、连接和行为
- 批准号:
10117139 - 财政年份:2021
- 资助金额:
$ 37.59万 - 项目类别:
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
环境对大鼠感觉运动皮层的影响:功能组织、连接和行为
- 批准号:
10337134 - 财政年份:2021
- 资助金额:
$ 37.59万 - 项目类别:
How Does Early Sensory Experience Affect Cortical Connections and Behavior?
早期感官体验如何影响皮质连接和行为?
- 批准号:
9030107 - 财政年份:2015
- 资助金额:
$ 37.59万 - 项目类别:
How Does Early Sensory Experience Affect Cortical Connections and Behavior?
早期感官体验如何影响皮质连接和行为?
- 批准号:
9197675 - 财政年份:2015
- 资助金额:
$ 37.59万 - 项目类别:
Can Cortical Plasticity be Directed and Amplified Following Early Loss of Vision?
早期视力丧失后皮质可塑性可以被引导和增强吗?
- 批准号:
8600683 - 财政年份:2013
- 资助金额:
$ 37.59万 - 项目类别:
Can Cortical Plasticity be Directed and Amplified Following Early Loss of Vision?
早期视力丧失后皮质可塑性可以被引导和增强吗?
- 批准号:
8821621 - 财政年份:2013
- 资助金额:
$ 37.59万 - 项目类别:
Effects of Reversible Deactivation of Posterior Parietal Cortex in New World Cebu
宿雾新世界后顶叶皮质可逆失活的影响
- 批准号:
8634824 - 财政年份:2013
- 资助金额:
$ 37.59万 - 项目类别:
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